Results 11 to 20 of about 2,716,407 (409)

Potential role of HTLV-1 Tax-specific cytotoxic t lymphocytes expressing a unique t-cell receptor to promote inflammation of the central nervous system in myelopathy associated with HTLV-1

Frontiers in Immunology, 2022
Human T-lymphotropic virus 1 (HTLV-1) infection causes two serious diseases: adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy (HAM).
Yukie Tanaka, Yukie Tanaka, Tomoo Sato, Tomoo Sato, Naoko Yagishita, Junji Yamauchi, Junji Yamauchi, Natsumi Araya, Satoko Aratani, Satoko Aratani, Katsunori Takahashi, Yasuo Kunitomo, Misako Nagasaka, Misako Nagasaka, Yoshinobu Kanda, Yoshinobu Kanda, Kaoru Uchimaru, Kaoru Uchimaru, Tomohiro Morio, Yoshihisa Yamano, Yoshihisa Yamano   +20 more
doaj   +1 more source

In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells. [PDF]

PLoS Pathogens, 2010
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms.
Joseph K Wong, Matthew C Strain, Rodin Porrata, Elizabeth Reay, Sumathi Sankaran-Walters, Caroline C Ignacio, Theresa Russell, Satish K Pillai, David J Looney, Satya Dandekar   +9 more
doaj   +1 more source

Antigen-specific B cells reactivate an effective cytotoxic T cell response against phagocytosed Salmonella through cross-presentation. [PDF]

PLoS ONE, 2010
BACKGROUND: The eradication of facultative intracellular bacterial pathogens, like Salmonella typhi, requires the concerted action of both the humoral immune response and the cytotoxic CD8(+) T cell response.
Jelle de Wit, Yuri Souwer, Tineke Jorritsma, Hanny Klaasse Bos, Anja ten Brinke, Jacques Neefjes, S Marieke van Ham   +6 more
doaj   +1 more source

The Expanding Arsenal of Cytotoxic T Cells

Frontiers in Immunology, 2022
Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on their cellular target, CTLs assemble an immunological synapse where they mobilise their killing machinery that is released into the synaptic cleft to orchestrate the demise
Cassioli, Chiara, Baldari, Cosima T
openaire   +5 more sources

Rapid Manufacturing of Highly Cytotoxic Clinical-Grade SARS-CoV-2-specific T Cell Products Covering SARS-CoV-2 and Its Variants for Adoptive T Cell Therapy

Frontiers in Bioengineering and Biotechnology, 2022
Objectives: Evaluation of the feasibility of SARS-CoV-2-specific T cell manufacturing for adoptive T cell transfer in COVID-19 patients at risk to develop severe disease.Methods: Antiviral SARS-CoV-2-specific T cells were detected in blood of ...
Agnes Bonifacius, Sabine Tischer-Zimmermann, Maria Michela Santamorena, Philip Mausberg, Josephine Schenk, Stephanie Koch, Johanna Barnstorf-Brandes, Nina Gödecke, Jörg Martens, Lilia Goudeva, Murielle Verboom, Jana Wittig, Jana Wittig, Britta Maecker-Kolhoff, Herrad Baurmann, Caren Clark, Olaf Brauns, Martina Simon, Peter Lang, Oliver A. Cornely, Oliver A. Cornely, Oliver A. Cornely, Oliver A. Cornely, Michael Hallek, Rainer Blasczyk, Dominic Seiferling, Philipp Köhler, Philipp Köhler, Britta Eiz-Vesper   +28 more
doaj   +1 more source

Exosomal LGALS9 in the cerebrospinal fluid of glioblastoma patients suppressed dendritic cell antigen presentation and cytotoxic T-cell immunity

Cell Death and Disease, 2020
Glioblastoma multiforme (GBM) is highly invasive, with a high recurrence rate and limited treatment options, and is the deadliest glioma. Exosomes (Exos) have attracted much attention in the diagnosis and treatment of GBM and are expected to address the ...
Ming Wang, Yang Cai, Yong Peng, Bo Xu, Wentao Hui, Yugang Jiang   +5 more
semanticscholar   +1 more source

The Era of Cytotoxic CD4 T Cells

Frontiers in Immunology, 2022
In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three decades, our understanding of CD4 T cell differentiation has expanded and the initial paradigm of a dichotomic CD4 T cell family has been revisited to accommodate a ...
Mara Cenerenti, Mara Cenerenti, Margaux Saillard, Margaux Saillard, Pedro Romero, Pedro Romero, Camilla Jandus, Camilla Jandus   +7 more
openaire   +4 more sources

Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse

eLife, 2020
Understanding T cell function in vivo is of key importance for basic and translational immunology alike. To study T cells in vivo, we developed a new knock-in mouse line, which expresses a fusion protein of granzyme B, a key component of cytotoxic ...
Praneeth Chitirala, Hsin-Fang Chang, Paloma Martzloff, Christiane Harenberg, Keerthana Ravichandran, Midhat H Abdulreda, Per-Olof Berggren, Elmar Krause, Claudia Schirra, Trese Leinders-Zufall, Fritz Benseler, Nils Brose, Jens Rettig   +12 more
doaj   +1 more source

Single-Cell Transcriptomics Reveals Killing Mechanisms of Antitumor Cytotoxic CD4+ TCR-T Cells

Frontiers in Immunology, 2022
T cell receptor-engineered T cells (TCR-Ts) have emerged as potent cancer immunotherapies. While most research focused on classical cytotoxic CD8+ T cells, the application of CD4+ T cells in adoptive T cell therapy has gained much interest recently ...
Yanling Liang, Yanling Liang, Qumiao Xu, Songming Liu, Jie Li, Jie Li, Fei Wang, Ziyi Li, Lijuan Liao, Yuting Lu, Yijian Li, Feng Mu, Hai-Xi Sun, Hai-Xi Sun, Hai-Xi Sun, Linnan Zhu, Linnan Zhu, Linnan Zhu   +17 more
doaj   +1 more source

BCL-2 antagonism sensitizes cytotoxic t cell-resistant hiv reservoirs to elimination ex vivo.

Journal of Clinical Investigation, 2020
Curing HIV infection will require the elimination of a reservoir of infected CD4+ T-cells that persists despite HIV-specific cytotoxic T-cell (CTL) responses.
Yanqin Ren, Szu-Han Huang, Shabnum Patel, W. C. Alberto, D. Magat, D. Ahimovic, A. Macedo, R. Durga, D. Chan, Elizabeth Zale, T. Mota, R. Truong, Thomas M. Rohwetter, C. McCann, Colin M. Kovacs, E. Benko, Avery Wimpelberg, Christopher M Cannon, W. David Hardy, A. Bosque, C. Bollard, R. B. Jones   +21 more
semanticscholar   +1 more source