Results 11 to 20 of about 2,869,113 (404)
Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant. [PDF]
PLoS Pathogens, 2008 High affinity antigen-specific T cells play a critical role during protective immune responses. Epitope enhancement can elicit more potent T cell responses and can subsequently lead to a stronger memory pool; however, the molecular basis of such ...
Noah S Butler +8 more
doaj +1 more source
Autophagy induced macrophages by α-alumina(α-AL2O3) conjugated cysteine peptidase, enhances the cytotoxic activity of CD8+ T lymphocytes against Leishmania major [PDF]
BioImpacts, 2023 Introduction: Induction of a protective immune response against Leishmania major requires the activation of both TH1 and CD8+ T lymphocytes. Because L. major is an intra-phagosomal parasite, its antigens do not have access to MHC-I.
Fatemeh Beyzay +4 more
doaj +1 more source
Frontiers in Immunology, 2022 Human T-lymphotropic virus 1 (HTLV-1) infection causes two serious diseases: adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy (HAM).
Yukie Tanaka +20 more
doaj +1 more source
Cytotoxic T cells and mycobacteria [PDF]
FEMS Microbiology Letters, 2001 How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to ...
Célio Lopes Silva +7 more
openaire +3 more sources
Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients
mBio, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic T cell response has not been
Jaana Westmeier +19 more
doaj +1 more source
Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity. [PDF]
PLoS ONE, 2013 Existing approaches that quantify cytotoxic T cell responses rely on bulk or surrogate measurements which impede the direct identification of single activated T cells of interest.
Thomas A Zangle +4 more
doaj +1 more source
The Expanding Arsenal of Cytotoxic T Cells
Frontiers in Immunology, 2022 Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on their cellular target, CTLs assemble an immunological synapse where they mobilise their killing machinery that is released into the synaptic cleft to orchestrate the demise
Cassioli, Chiara, Baldari, Cosima T
openaire +5 more sources
Frontiers in Bioengineering and Biotechnology, 2022 Objectives: Evaluation of the feasibility of SARS-CoV-2-specific T cell manufacturing for adoptive T cell transfer in COVID-19 patients at risk to develop severe disease.Methods: Antiviral SARS-CoV-2-specific T cells were detected in blood of ...
Agnes Bonifacius +28 more
doaj +1 more source
Cell Death and Disease, 2020 Glioblastoma multiforme (GBM) is highly invasive, with a high recurrence rate and limited treatment options, and is the deadliest glioma. Exosomes (Exos) have attracted much attention in the diagnosis and treatment of GBM and are expected to address the ...
Ming Wang +5 more
semanticscholar +1 more source
BCL-2 antagonism sensitizes cytotoxic t cell-resistant hiv reservoirs to elimination ex vivo.
Journal of Clinical Investigation, 2020 Curing HIV infection will require the elimination of a reservoir of infected CD4+ T-cells that persists despite HIV-specific cytotoxic T-cell (CTL) responses.
Yanqin Ren +21 more
semanticscholar +1 more source