Results 211 to 220 of about 518,936 (262)

T-cell mediator induction of non-T-cell cytotoxicity

Cellular Immunology, 1976
Publisher Summary This chapter focuses on the nonspecific lymphocyte cytotoxicity for allogeneic target cells, also termed spontaneous cytotoxicity or background cytotoxicity reported by several investigators studying graft rejection and tumor immunology phenomena.
Peggy A. O'Neill, Bruce F. Mackler
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Cytotoxic T cells – Stroma interactions

Bulletin du Cancer, 2011
The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators ...
Muhammad Zaeem, Noman, Houssem, Benlalam, Meriem, Hasmim, Salem, Chouaib   +3 more
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Cytotoxic human CD4+ T cells

Current Opinion in Immunology, 2008
The induction of adaptive immune responses critically depends on helper signals provided by CD4(+) T cells. These signals not only license antigen presenting cells (APC) to activate naïve CD8(+) T cells leading to the formation of vast numbers of cytotoxic T lymphocytes but also support the differentiation of B cells into immunoglobulin-secreting ...
Pablo J, van de Berg, Ester M, van Leeuwen, Ineke J, ten Berge, Rene, van Lier   +3 more
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Enumeration of specific cytotoxic T cells

Nature, 1976
EFFORTS directed towards the enumeration of effector cells involved in the cell-mediated immune response have so far met with little success. One of the principal reasons for this failure is the current ignorance of relationships between killer, lymphokine producer and suppressor T cells, all of which have effector functions.
Thorn, R M, Henney, C S
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Aspects of Cytotoxic T Cell Memory

Immunological Reviews, 1996
Immunological T cell memory manifest itself in an accelerated second-set graft, or allogeneic tumour cell, rejection. Memory viral-immune cytotoxic T cells have shortened kinetics of induction in vivo and differentiate into more potent effector cells in vitro.
A, Müllbacher, K, Flynn
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[Cytotoxic T cell].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2004
Cytotoxic T cell (CTL) covers several subtypes, which are CD8+, CD4 and CD4-CD8-. CTL derives from T cell repertoire in lymphoid hematopoietic stem cells. It matures in thymus and is activated in peripheral lymphoid tissues. Effector CTL kills the target cells by 2 ways.
Ge, Ma, Li-ping, Zhu, Wei, Zhang
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Clonal Cytotoxic T Cells in Myeloma

Leukemia & Lymphoma, 2003
Multiple myeloma (MM) is a malignant disease characterized by accumulation of morphologically recognizable plasma cells producing immunoglobulin (Ig) in the bone marrow. The occurrence of clonal T cells in MM, as defined by the presence of rearrangements in the T-cell receptor (TCR)-beta chains detected on Southern blotting, is associated with an ...
Daniel M Y, Sze, Ross D, Brown, Edna, Yuen, John, Gibson, Joy, Ho, Maria, Raitakari, Antony, Basten, Douglas E, Joshua, Barbara, Fazekas de St Groth   +8 more
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The cell identity of cytotoxic T lymphocytes

Nature Immunology, 2015
Understanding cytotoxic T cells has been a major focus of immunology research for decades. Proteomic profiling of these cells now brings them into unprecedented and revealing focus.
David E, Sanin, Edward J, Pearce
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Cytotoxic T cells in teleost fish

Developmental & Comparative Immunology, 2011
The presence of antigen-specific cytotoxic T cells has been suggested in a number of in vivo and in vitro studies in fish. Acute allograft rejection with an accelerated response on second-set grafts and the presence of graft-versus-host reaction (GVHR) has been reported in teleost. Alloantigen- and virus-specific cytotoxicity has also been demonstrated
Teruyuki, Nakanishi, Hideaki, Toda, Yasuhiro, Shibasaki, Tomonori, Somamoto   +3 more
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Mechanisms of Lysis by Cytotoxic T Cells

Critical Reviews™ in Immunology, 1995
When a cytotoxic lymphocyte binds to an antigenic cell, there is a reorientation of the Golgi apparatus and a directed exocytosis of cytoplasmic granules toward the offending cell. In the model originally proposed by Henkart, these granules were hypothesized to contain lytic molecules that contribute to the demise of the target cell.
E A, Atkinson, R C, Bleackley
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