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Fish & Shellfish Immunology, 2019
Cell-mediated cytotoxicity is one of the major mechanisms by which vertebrates control intracellular pathogens. Two cell types are the main players in this immune response, natural killer (NK) cells and cytotoxic T lymphocytes (CTL). While NK cells recognize altered target cells in a relatively unspecific manner CTLs use their T cell receptor to ...
Takuya Yamaguchi +5 more
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Cell-mediated cytotoxicity is one of the major mechanisms by which vertebrates control intracellular pathogens. Two cell types are the main players in this immune response, natural killer (NK) cells and cytotoxic T lymphocytes (CTL). While NK cells recognize altered target cells in a relatively unspecific manner CTLs use their T cell receptor to ...
Takuya Yamaguchi +5 more
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Alloreactive cytotoxic T cells. I. Alloreactive and allorestricted cytotoxic T cells
European Journal of Immunology, 1985AbstractNylon wool‐nonadherent spleen cells from three inbred mouse strains of H‐2k (CBA), H‐2d (BALB/c) and H‐2b (C57BL/6) haplotype were co‐cultured with 2,4,6‐ trinitro‐ phenyl (TNP)‐ modified or nonmodified allogeneic stimulator cells in a limiting dilution system.
J, Reimann +3 more
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Sensitivity of cytotoxic T cells to T-cell mediated cytotoxicity
Nature, 1974LYMPHOID cells sensitised against alloantigens can lyse in vitro target cells bearing these alloantigens1,2. In most of the experimental systems using in vivo sensitised cells, T cells (thymus-dependent lymphocytes) are both necessary3 and sufficient4,5 for induction of target cell lysis.
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Current Opinion in Immunology, 1991
There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting distinct effector functions expressed by different killer ...
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There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting distinct effector functions expressed by different killer ...
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Nature, 1994
It has been suggested that mutations within immunodominant cytotoxic T-lymphocyte (CTL) epitopes may be exploited by viruses to evade protective immune responses critical for clearance. Viral escape could originate from passive mechanisms, such as mutations within crucial CTL epitopes, either affecting major histocompatibility complex binding or T-cell
Antonio Bertoletti +7 more
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It has been suggested that mutations within immunodominant cytotoxic T-lymphocyte (CTL) epitopes may be exploited by viruses to evade protective immune responses critical for clearance. Viral escape could originate from passive mechanisms, such as mutations within crucial CTL epitopes, either affecting major histocompatibility complex binding or T-cell
Antonio Bertoletti +7 more
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T-cell mediator induction of non-T-cell cytotoxicity
Cellular Immunology, 1976Publisher Summary This chapter focuses on the nonspecific lymphocyte cytotoxicity for allogeneic target cells, also termed spontaneous cytotoxicity or background cytotoxicity reported by several investigators studying graft rejection and tumor immunology phenomena.
Peggy A. O'Neill, Bruce F. Mackler
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Enumeration of specific cytotoxic T cells
Nature, 1976EFFORTS directed towards the enumeration of effector cells involved in the cell-mediated immune response have so far met with little success. One of the principal reasons for this failure is the current ignorance of relationships between killer, lymphokine producer and suppressor T cells, all of which have effector functions.
Thorn, R M, Henney, C S
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Cytotoxic T cells – Stroma interactions
Bulletin du Cancer, 2011The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators ...
Muhammad Zaeem, Noman +3 more
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Current Opinion in Immunology, 2008
The induction of adaptive immune responses critically depends on helper signals provided by CD4(+) T cells. These signals not only license antigen presenting cells (APC) to activate naïve CD8(+) T cells leading to the formation of vast numbers of cytotoxic T lymphocytes but also support the differentiation of B cells into immunoglobulin-secreting ...
Pablo J, van de Berg +3 more
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The induction of adaptive immune responses critically depends on helper signals provided by CD4(+) T cells. These signals not only license antigen presenting cells (APC) to activate naïve CD8(+) T cells leading to the formation of vast numbers of cytotoxic T lymphocytes but also support the differentiation of B cells into immunoglobulin-secreting ...
Pablo J, van de Berg +3 more
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Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2004
Cytotoxic T cell (CTL) covers several subtypes, which are CD8+, CD4 and CD4-CD8-. CTL derives from T cell repertoire in lymphoid hematopoietic stem cells. It matures in thymus and is activated in peripheral lymphoid tissues. Effector CTL kills the target cells by 2 ways.
Ge, Ma, Li-ping, Zhu, Wei, Zhang
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Cytotoxic T cell (CTL) covers several subtypes, which are CD8+, CD4 and CD4-CD8-. CTL derives from T cell repertoire in lymphoid hematopoietic stem cells. It matures in thymus and is activated in peripheral lymphoid tissues. Effector CTL kills the target cells by 2 ways.
Ge, Ma, Li-ping, Zhu, Wei, Zhang
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