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Aspects of Cytotoxic T Cell Memory
Immunological Reviews, 1996Immunological T cell memory manifest itself in an accelerated second-set graft, or allogeneic tumour cell, rejection. Memory viral-immune cytotoxic T cells have shortened kinetics of induction in vivo and differentiate into more potent effector cells in vitro.
A, Müllbacher, K, Flynn
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Clonal Cytotoxic T Cells in Myeloma
Leukemia & Lymphoma, 2003Multiple myeloma (MM) is a malignant disease characterized by accumulation of morphologically recognizable plasma cells producing immunoglobulin (Ig) in the bone marrow. The occurrence of clonal T cells in MM, as defined by the presence of rearrangements in the T-cell receptor (TCR)-beta chains detected on Southern blotting, is associated with an ...
Daniel M Y, Sze +8 more
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The cell identity of cytotoxic T lymphocytes
Nature Immunology, 2015Understanding cytotoxic T cells has been a major focus of immunology research for decades. Proteomic profiling of these cells now brings them into unprecedented and revealing focus.
David E, Sanin, Edward J, Pearce
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Cytotoxic T cells in teleost fish
Developmental & Comparative Immunology, 2011The presence of antigen-specific cytotoxic T cells has been suggested in a number of in vivo and in vitro studies in fish. Acute allograft rejection with an accelerated response on second-set grafts and the presence of graft-versus-host reaction (GVHR) has been reported in teleost. Alloantigen- and virus-specific cytotoxicity has also been demonstrated
Teruyuki, Nakanishi +3 more
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Mechanisms of Lysis by Cytotoxic T Cells
Critical Reviews™ in Immunology, 1995When a cytotoxic lymphocyte binds to an antigenic cell, there is a reorientation of the Golgi apparatus and a directed exocytosis of cytoplasmic granules toward the offending cell. In the model originally proposed by Henkart, these granules were hypothesized to contain lytic molecules that contribute to the demise of the target cell.
E A, Atkinson, R C, Bleackley
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Cytotoxic T cell function in fish
Developmental & Comparative Immunology, 2002Fish possess immunoglobulins, major histocompatibility complex (MHC), T-cell receptors, and lymphocyte populations analogous to B and T cells and can evoke specific immune responses against a variety of antigens. However, T-cell subsets have yet to be demonstrated and the information on cell-mediated immunity is limited.
T, Nakanishi +6 more
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Human mucosal T-cell cytotoxicity
Gastroenterology, 1988Non-major histocompatibility complex-restricted cytotoxicity triggered by antibodies to the CD3 component of the human T-cell receptor complex is thought to be an indirect measure of in vivo primed cytotoxic T-cell activity. We have used this technique to examine the lytic activity of freshly isolated T cells from noninflamed human colonic mucosa. Anti-
F, Shanahan +4 more
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Targeting of Eythrocytes to Cytotoxic T-Cells
1992The treatment and therapy of many acute and chronic illnesses have largely involved the administration of drugs via the standard delivery systems, e.g. oral, parenteral, intra-muscular, and intravenous administration. These methods of administering a drug usually result in an immediate bio-availability of the drug.
CHIARANTINI, LAURA +4 more
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Continuous Cytotoxic T-Cell Lines
1980Recently, it was reported that it was possible to maintain normal human T lymphocytes in continuous exponential proliferative culture with the aid of a T-cell growth factor (TCGF) derived from lectin-stimulated peripheral blood mononuclear cells (Morgan et al., 1976; Ruscetti et al., 1977). Subsequently, we (Gillis and Smith, 1977; Gillis et al., 1978a;
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Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones
Immunity, 2022Jack A Collora +2 more
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