Results 201 to 210 of about 812,769 (307)

Cytotoxic T Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy. [PDF]

Circ Res
Sikking MA, Harding D, Henkens MTHM, Stroeks SLVM, Venner MFGHM, Nihant B, van Leeuwen REW, Fanti S, Li X, van Paassen P, Knackstedt C, Brunner-la Rocca HP, van Empel VPM, Verdonschot JAJ, Marelli-Berg FM, Heymans SRB.   +15 more
europepmc   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Tebentafusp elicits on-target cutaneous immune responses driven by cytotoxic T cells in uveal melanoma patients. [PDF]

J Clin Invest
Staeger R, Tastanova A, Ghosh A, Winkelbeiner N, Shukla P, Kolm I, Turko P, Benlahrech A, Harper J, Broomfield A, Camera A, Ambrosio M, Haunerdinger V, Cheng PF, Ramelyte E, Pham J, Kreutmair S, Becher B, Levesque MP, Dummer R, Meier-Schiesser B.   +20 more
europepmc   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Tumor cell spheroid-induced suppression of primary human cytotoxic T cells as a scalable <i>in vitro</i> model of exhaustion. [PDF]

Immunother Adv
Alsubaiti A, Alamir H, Huynh L, Grant T, Aljohani A, Chou PH, Shi Y, Alismail M, Mason LR, Herman A, Bridgeman JS, Holland CJ, Wülfing C.   +12 more
europepmc   +1 more source

Generation of virus specific cytotoxic T cells in vitro [PDF]

, 1979
Greber, D., Koszinowski, Ulrich H., Neuschaefer-Rube, I.   +2 more
core  

Interconnected Porous Hydrogels with Tunable Anisotropy Through Aqueous Emulsion Bioprinting

Advanced Functional Materials, EarlyView.
A 3D bioprintable microporous bioink is developed using an aqueous two‐phase system (ATPS) composed of extracellular matrix (ECM) mimetic biopolymers. The ATPS bioink enables the fabrication of interconnected porous architectures with up to 70% porosity, supporting long‐term cell viability and 3D cell alignment, enabling a simultaneous generation of ...
Hugo Edgar‐Vilar, Francisca P. Correia, Inês M. Freitas, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

CD19-ReTARG^TPR: A Novel Fusion Protein for Physiological Engagement of Anti-CMV Cytotoxic T Cells Against CD19-Expressing Malignancies. [PDF]

Cancers (Basel)
van Wijngaarden AP, Britsch I, Peipp M, Samplonius DF, Helfrich W.   +4 more
europepmc   +1 more source

Transcriptional and Clonal Characterization of Cytotoxic T Cells in Crescentic Glomerulonephritis.

J Am Soc Nephrol, 2023
Mueller A, Zhao Y, Cicek H, Paust HJ, Sivayoganathan A, Linke A, Wegscheid C, Wiech T, Huber TB, Meyer-Schwesinger C, Bonn S, Prinz I, Panzer U, Tiegs G, Krebs CF, Neumann K.   +15 more
europepmc   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source