Results 231 to 240 of about 733,847 (374)

Cells expressing herpes simplex virus glycoprotein gC but not gB, gD, or gE are recognized by murine virus-specific cytotoxic T lymphocytes [PDF]

, 1987
K L Rosenthal, James R. Smiley, Sarah T. South, David C. Johnson   +3 more
openalex   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

B cell stimulatory factor 1 (IL-4) enhances the development of cytotoxic T cells from Lyt-2+ resting murine T lymphocytes. [PDF]

, 1988
Guido Trenn, Hajime Takayama, Jane Hu‐Li, W E Paul, M V Sitkovsky   +4 more
openalex   +1 more source

Genetically Engineered IL12/CSF1R‐Macrophage Membrane‐Liposome Hybrid Nanovesicles for NIR‐II Fluorescence Imaging‐Guided and Membrane‐Targeted Mild Photothermal‐Immunotherapy of Glioblastoma

Advanced Science, EarlyView.
A theranostic nanoplatform is formulated with NIR‐II emissive lipophilic cyanine dye IRC18 to intercalate into genetically engineered IL12/CSF1R‐macrophage membrane‐liposome hybrid nanovesicles, which assists to achieve blood–brain barrier crossing, glioblastoma targeting, NIR‐II fluorescence imaging, image‐guided membrane‐targeted mild photothermal ...
Pengfei Chen, Yue Liu, Haiyan Huang, Menglong Li, Hui Xie, Shubham Roy, Jingsi Gu, Jian Jin, Kai Deng, Lixin Du, Bing Guo   +10 more
wiley   +1 more source

Locoregional Immune Checkpoint Blockade and Remodeling of Lymph Nodes by Engineered Dendritic Cell‐Derived Exosomes for Suppressing Tumor Progression and Metastasis

Advanced Science, EarlyView.
The study develops engineered exosomes (EmDEX@GA) for locoregional immunomodulation of tumor‐draining lymph node (TDLN). EmDEX@GA can actively target to TDLN and remodel its immunosuppressive microenvironment through the synergistic effects of PD‐1/PD‐L1 blockade and STING pathway activation, subsequently enhance anti‐tumor immunity and suppress tumor ...
Yizhen Wang, Xiaomin Guo, Jingya Qin, Yifan Xue, Peng Zhang, Yadong Liu, Moyang Chen, Guanghao Zhu, Xinqiu Song, Lili Cheng, Bo Liu, Jie Liu, Jie Ren   +12 more
wiley   +1 more source

Demonstration of multiple antigenic sites of the SV40 transplantation rejection antigen by using cytotoxic T lymphocyte clones. [PDF]

, 1983
Ann E. Campbell, F L Foley, Satvir S. Tevethia   +2 more
openalex   +1 more source

An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy

Advanced Science, EarlyView.
This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma, Jie Wang, Min Jiang, Juanhua He, Fangyang Li, Dan Lu, Chao Su, Yan Chai, Wenjing Jin, Yu Chen, Catherine W.H. Zhang, Xiaopeng Ma, Hui Tan, George F. Gao, Shuguang Tan   +14 more
wiley   +1 more source

In vivo administration of histoincompatible lymphocytes leads to rapid functional deletion of cytotoxic T lymphocyte precursors. [PDF]

, 1989
D. R. Martin, R. G. Miller
openalex   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes. [PDF]

, 1989
J. Lindsay Whitton, Michael B. A. Oldstone   +1 more
openalex   +1 more source