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Cytotoxic T Lymphocytes and Vaccine Development [PDF]
Journal of Biomedicine and Biotechnology, 2010 Xiao, Zhengguo +2 more
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Data-driven Nucleus Subclassification on Colon H&E using Style-transferred Digital Pathology [PDF]
arXivUnderstanding the way cells communicate, co-locate, and interrelate is essential to furthering our understanding of how the body functions. H&E is widely available, however, cell subtyping often requires expert knowledge and the use of specialized stains. To reduce the annotation burden, AI has been proposed for the classification of cells on H&E.
arxiv
Nucleus subtype classification using inter-modality learning [PDF]
arXivUnderstanding the way cells communicate, co-locate, and interrelate is essential to understanding human physiology. Hematoxylin and eosin (H&E) staining is ubiquitously available both for clinical studies and research. The Colon Nucleus Identification and Classification (CoNIC) Challenge has recently innovated on robust artificial intelligence labeling
arxiv
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Cytotoxic Activity of Lymphocytes
The Journal of Immunology, 1972Abstract Antibody to human lymphotoxin was elicited in rabbits immunized with partially purified supernatants of human spleen cells stimulated by phytohemagglutinin; Anti-LT activity, assayed by neutralizing soluble LT toxicity to indicator mouse L cells, is confined to the immunoglobulin fraction of the serum; it cannot be removed by ...
Sharyn M. Walker, Zoltan J. Lucas
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Lymphocyte-Mediated Cytotoxicity
Annual Review of Immunology, 2002Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the Fas pathway. The granule exocytosis pathway utilizes perforin to traffic the granzymes to appropriate locations in target cells, where they cleave critical substrates that ...
Timothy J. Ley, John H. Russell
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Endocytosis in cytotoxic T-lymphocytes
Cellular Immunology, 1981Abstract Endocytosis in T lymphocytes was analyzed during their differentiation into cytotoxic effector cells in allogeneic mixed lymphocyte cultures. We found that endocytic activity increases from a very low value to reach a peak at Day 5, at which time the cytotoxic titer is highest in these cell cultures.
Heiniger, H J +2 more
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T lymphocytes with promiscuous cytotoxicity
Nature, 1976CYTOTOXIC T lymphocytes generated during a unidirectional mixed lymphocyte culture (MLC) lyse target cells which have the antigenic phenotype of the allogeneic stimulating cells. The cytotoxic effect is restricted to cells that bear the same major histocompatibility antigens (H–2 antigens in mice) as the stimulating cells1.
Chaim Shustik +5 more
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Cytotoxic T lymphocytes and autoimmunity
Current Opinion in Rheumatology, 2005The possibility of the recognition by cytotoxic T lymphocytes of tissue autoantigens has been largely ignored in explaining organ-specific autoimmune diseases. Recent advances in the understanding of human leukocyte antigen class I-binding peptides motifs have led to the detection and the characterization of those autoreactive CD8(+) cytotoxic T ...
Patrick Blanco +3 more
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Studies on the Cytotoxicity of Lymphocytes [PDF]
, 1969 The higher organisms are equipped with two different systems for immunological defence. One system is characterized by the production of humoral antibodies, the other by the appearence of specifically sensitized lymphocytes, which are capable of direct interaction with the antigen.
W. Ax, H. Fischer, I. Zeiss, H. Malchow
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The stepwise activation of cytotoxic T lymphocytes
Immunology Today, 1987The recognition of antigen is the first stage of T-lymphocyte maturation in vivo. Monoclonal antibodies directed against the T-cell receptor/CD3 complex and against other surface antigens can also provide this stimulus. Gianni Gromo and his colleagues are attempting to characterize the steps leading from this initial activation to full functional ...
R. L. Geller +4 more
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