Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins [PDF]
, 1993 The human serine proteases granzymes A and B are expressed in cytotoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. Recombinant granzyme A and granzyme B proteins were produced in bacteria, purified and then used to raise ...
Borst, Jannie +9 more
core +9 more sources
Influence of the age and disease colorectal in immunity cutaneous pericolostomic [PDF]
, 2009 Objective: describe the immunological response in the dermal layer of the peri-colostomic region. Method: Forty-one patients with colostomies realized over eight weeks previously, were included. For the analysis of the immunocellular response in the peri-
Franco, Marcello Fabiano de +4 more
core +4 more sources
Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema
Respiratory Research, 2007 Background It is generally accepted that emphysematous lungs are characterized by an increase in the numbers of neutrophils, macrophages, and CD8+ T lymphocytes, the lasts having increased cytotoxic activity.
Parent Julie +2 more
doaj +1 more source
Natural Killer cells responsiveness to physical esercise: a brief review [PDF]
, 2013 Natural killer cells (NK) are a group of peripheral blood lymphocytes which display cytotoxic ac- tivity against a wide range of tumour cells. They are a consistent part of the inflammatory re- sponse that is activated when either internal or external ...
Concu A. +4 more
core +1 more source
HLA-DR in Cytotoxic T lymphocytes predicts breast cancer patients' response to neoadjuvant chemotherapy [PDF]
, 2018 Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies.
Borralho, Paula +4 more
core +2 more sources
PLoS Pathogens, 2020 Human cytomegalovirus (HCMV) is the most frequent viral cause of congenital defects and can trigger devastating disease in immune-suppressed patients. Cytotoxic lymphocytes (CD8+ T cells and NK cells) control HCMV infection by releasing interferon-γ and ...
Liling Shan +12 more
doaj +1 more source
Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma [PDF]
, 2000 Immune surveillance by cytotoxic lymphocytes against cancer has been postulated for decades, but direct evidence for the role of cytotoxic lymphocytes in protecting against spontaneous malignancy has been lacking.
Godfrey, DI +5 more
core +2 more sources
Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells [PDF]
, 2010 The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune ...
Gong, Jianlin +6 more
core +10 more sources
Cytotoxic T lymphocytes in regional lymph nodes in colon cancer
Acta Biomedica ScientificaBackground. The study of the subpopulation composition of cytotoxic T lymphocytes and the expression of co-inhibitory proteins on their surface in regional lymph nodes is necessary for the development of new methods of targeted therapy for colorectal ...
V. V. Kryukova +2 more
doaj +1 more source
Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7
Frontiers in Immunology, 2019 Cytotoxic T lymphocytes kill infected or malignant cells through the directed release of cytotoxic substances at the site of target cell contact, the immunological synapse.
Praneeth Chitirala +6 more
doaj +1 more source