Results 41 to 50 of about 213,002 (75)

The Role of Cytoplasmic Granules in Cytotoxicity by Large Granular Lymphocytes and Cytotoxic T Lymphocytes

1985
Three years ago, at the First Workshop on Mechansisms of Cell-Mediated Cytotoxicity, we presented a summary of the evidence developed in our lab that the ADCC and NK cytotoxic functions of large granular lymphocytes (LGL) operated via a secretory process (1).
Pierre A. Henkart, Maryanna Henkart, Peter H. Frederikse, Paul J. Millard, Craig W. Reynolds, Cho Yue, Robert Blumenthal, Jeff Bluestone   +7 more
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Suppressor‐Cytotoxic T‐Lymphocyte Panniculitis

Pediatric Dermatology, 1986
Abstract: A 3½‐year‐old girl had fever and nonsuppurative panniculitis. Biopsies revealed lobular lymphocytic panniculitis. An extensive evaluation of the patient for infectious and other systemic diseases yielded negative results. Although the number of peripheral T lymphocytes was normal, suppressor‐cytotoxic (0KT8) lymphocytes predominated in the ...
Jaime E. Ramirez, Srinivasan Rajaraman, Anand G. Kantak, Armond S. Goldman, Sharon S. Raimer, Alvin R. Solomon   +5 more
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Cytotoxic Lymphocytes

1979
Publisher Summary This chapter discusses cytotoxic lymphocytes. Evaluation of the biological significance of the results of an in vitro assay is critically dependent on the correct assessment of the many limitations of the assay. Lymphocytes are mixed with proper target cells, and the ensuing damage of the latter is measured after incubation under ...
Peter Perlmann, Jean-Charles Cerottini
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Inhibition of cytotoxic T lymphocytes with concanavalin A

Cellular Immunology, 1980
Abstract Increasing concentrations of concanavalin A (ConA) were found to increasingly inhibit immunologically specific cytotoxic T lymphocyte (CTL)-mediated cytolysis. Even concentrations of ConA that best enabled nonspecific cytolysis were found to inhibit immunologically specific cytolysis by the same population of effector cells.
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Cytotoxic Lymphocytes and Cardiac Electrophysiology

Journal of Molecular and Cellular Cardiology, 2002
It is widely recognized that immune effector mechanisms contribute to cardiac dysfunction in major cardiac pathologies, such as myocarditis and the consequent dilated cardiomyopathy, Chagas' disease and heart transplant rejection. Of the wealth of immune mechanisms known to affect cardiac function, this review will deal with the adverse effects caused ...
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Cytotoxic T lymphocytes against HIV

AIDS, 1990
HIV-1 infection has clearly been shown to induce a vigorous CTL response in infected people, and this response is present at a time when immune function otherwise is globally impaired. HIV-1-specific CTL are detectable both in peripheral blood and tissues of infected people, and are aimed at multiple viral proteins.
Bruce D. Walker, Fernando Plata
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Killing Mechanisms of Cytotoxic T Lymphocytes

Physiology, 1998
Cytotoxic T lymphocytes mediate lysis of target cells by various mechanisms, including exocytosis of lytic proteins (perforin, granzymes) and receptor-ligand binding of Fas/APO molecules. Death of target cells is characterized by either necrosis or apoptosis, depending on the killing mechanism used and on the metabolism of the target cell itself.
Luis Filgueira, Peter Groscurth
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Lymphocyte-Mediated Cytotoxicity [PDF]

, 2010
1 Cytotoxic Lymphocytes 2 CTLs and NK Cell Morphology and Function 3 Killing 4 Composition of Cytolytic Granules of CTLs and NK Cells 5 Killer Cell Self-Protection 6 Target Cell Death 7 Role of Perforin in the Induction of CTL Activation 8 Perforin Function in Homeostasis 9 Homeostatic Function of Fas and Fas-L 10 ...
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Cytotoxic T lymphocytes in herpesvirus infections

Veterinary Immunology and Immunopathology, 1984
A. INTRODUCTION B. MEASUREMENT OF CTL AND THEIR DIFFERENTIATION FROM OTHER FORMS OF CYTOTOXICITY 1. The chromium re lease assay 2. S p e c i f i c i t y con t ro l s 3. I d e n t i f i c a t i o n of e f f e c t o r c e l l s w i th a l l o a n t i s e r a 4. Ef fec t of i n h i b i t o r s on CTL 5. Target c e l l s C.
Barry T. Rouse, David W. Horohov
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Calreticulin in Cytotoxic Lymphocyte-Mediated Cytotoxicity

2003
New functions are implicated for calreticulin, based on its release from cytotoxic NK and T cells. Calreticulin is the only one of six “KDEL” (Lys-Asp-Glu-Leu carboxy terminal) endoplasmic reticulum chaperone proteins present in cytotoxic granules of these lymphocytes.
Dorothy Hudig, Reza Karimi
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