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Targeting and Activation of Cytotoxic Lymphocytes
2015Des anticorps heteroconjugues ont permis d'etudier et de moduler la specificite des cellules cytotoxiques in vivo et in vitro. Il faut determiner quel anticorps bispecifique sera capable in vivo de «cibler» certaines cellules cytotoxiques qui pourront avoir des applications ...
David M. Segal, Denis P. Snider
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Cytotoxic T Lymphocytes in Resistance to Tuberculosis
1998Recent experimental evidence has suggested T cells recognizing antigens in the context of both classical MHC class I and nonclassical class I-like molecules contribute to protective responses against Mycobacterium tuberculosis (MTB) infection. Our aims were to characterize both types of T cells, and to explore the basis of communication between the ...
Barry R. Bloom +6 more
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Cytotoxic lymphocyte‐mediated immunotherapy
Australian and New Zealand Journal of Medicine, 1995Abstract:Cytotoxic CD8+ T cells and NK cells play a role in the elimination of some viruses, graft rejection, antitumour responses, immuno regulation and some autoimmune diseases. The central importance of these cells in each of these immune responses and the therapeutic potential they offer, when effectively targeted, has justified continued interest ...
Mark J. Smyth, Michael H. Kershaw
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Collaboration of helper and cytotoxic T lymphocytes
European Journal of Immunology, 1993AbstractCytotoxic T lymphocytes are major effector cells in responses to viral infections and in allograft rejection and are implicated in many other immunological reactions. Efficient induction of cytotoxic activity in these cells in many but not all cases depends upon helper Tand antigen‐presenting cells so that at least three different cell types ...
Peter Walden, Gemot Stuhler
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The role of cytotoxicity in lymphocyte homeostasis
Current Opinion in Immunology, 2001Several human inherited immune disorders lead to the same fatal lymphoproliferative syndrome, called the hemophagocytic syndrome. Through defective perforin expression or transport, these disorders highlight the determinant role of the secretory cytotoxic pathway in the regulation of the immune response and in lymphocyte homeostasis.
Alain Fischer +1 more
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Cytotoxic lymphocytes in melanoma patients
International Journal of Cancer, 1972AbstractPeripheral blood lymphocytes from 61 melanoma patients were tested by a microcytotoxicity test for cell‐mediated immunity against melanoma cells. Lymphocytes from 13/25 patients were cytotoxic for autologous tumour cells, while lymphocytes from 31/56 patients were cytotoxic in the allogeneic situation.
J P, Faucault +3 more
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Activation of Cytotoxic Function in T Lymphocytes
The Journal of Immunology, 1976Abstract The requirements for activation of cytotoxic function in mouse T lymphocytes were investigated. Initial generation of cytotoxicity in normal lymphocytes was equal in magnitude with either Con A or specific alloantigen, and in either case required DNA synthesis.
Heininger, D +3 more
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Killing mechanisms of cytotoxic lymphocytes
Current Opinion in Hematology, 1997Killer lymphocytes are primary immune effectors of virus, certain bacteria, and tumor immunity and play a role in autoimmunity and transplant rejection. This article reviews progress in deciphering the mechanisms by which they kill target cells through induction of apoptosis by either the secretory, perforin/granzyme-based pathway or the nonsecretory ...
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CD4 cytotoxic T lymphocyte differentiation
Biochimie, 1988In vitro allostimulated CD4+ human lymphocytes were cloned by micromanipulation and expanded for a short time in IL-2 conditioned medium. In the present study we observed that proliferative noncytotoxic cloned cells were able to acquire the specific cytolytic activity under some modification of the cloned cells restimulation cycle. We demonstrated that
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THE MECHANISM OF LYMPHOCYTE‐MEDIATED CYTOTOXICITY
Biological Reviews, 1981Summary1. Three classes of cytotoxic lymphocyte are discussed: thymus‐derived T cells, antibody‐dependent K cells and NK (natural killer) cells. Each of these cytotoxic lymphocytes has receptors allowing the formation of adhesions (contact) with a target cell (the cell to be killed).
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