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Cytotoxicity of Dendrimers [PDF]
Biomolecules, 2019 Drug delivery systems are molecular platforms in which an active compound is packed into or loaded on a biocompatible nanoparticle. Such a solution improves the activity of the applied drug or decreases its side effects.
Anna Janaszewska +4 more
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Lymphocyte Cytotoxicity in vitro: Activation and Release of a Cytotoxic Factor [PDF]
Nature, 1968 WE have reported that cell contact per se is not sufficient to explain the rapid and dramatic in vitro destruction of target L cells observed when they are treated with immune lymphocytes or non-immune phytohaemagglutinin (PHA)-stimulated lymphocytes derived from various inbred mice1.
Gale A. Granger, Terry W. Williams
openalex +6 more sources
High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity [PDF]
Frontiers in Immunology, 2021 Cytotoxic T lymphocytes (CTLs) are key players to eliminate tumorigenic or pathogen-infected cells using lytic granules (LG) and Fas ligand (FasL) pathways. Depletion of glucose leads to severely impaired cytotoxic function of CTLs. However, the impact of excessive glucose on CTL functions still remains largely unknown.
Jie Zhu +19 more
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Journal of Investigative Dermatology, 2006 The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Jürgen C. Becker +3 more
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Toxins, 2022 Safe working conditions must be guaranteed during waste sorting, which is crucial to maximizing recycling and reuse, in order to minimize workers’ exposure to chemical and biological hazards.
Carla Viegas +5 more
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Toxins, 2023 Background: Panton–Valentine Leukocidin sustains a strong cytotoxic activity, targeting immune cells and, consequently, perforating the plasma membrane and inducing cell death.
Abdullah AlSaleh +3 more
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Understanding of black salve toxicity by multi-compound cytotoxicity assays
BMC Complementary Medicine and Therapies, 2022 Background Black salve is a controversial complementary and alternative medicine (CAM) associated with skin toxicity and skin cancer treatment failures.
Andrew Croaker +4 more
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Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage. [PDF]
PLoS ONE, 2017 Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U.S. Tox21 screening program, the cytotoxicity of ~10K chemicals was interrogated at 0, 8, 16, 24, 32, & 40 hours of exposure in a concentration ...
Jui-Hua Hsieh +8 more
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Frontiers in Microbiology, 2021 Hypersaline environments are known to support diverse fungal species from various orders. The production of secondary metabolites is one of the strategies that fungi adopt to thrive under such extreme environments, bringing up the stress tolerance ...
Subhadarsini Sahoo +2 more
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Frontiers in Immunology, 2020 Background: Measurement of natural killer (NK) cell function has important clinical utility in several diseases. Although the flow cytometry (FC)-based 4-h NK cytotoxicity assay using peripheral blood mononuclear cells (PBMCs) in the clinical laboratory ...
Jinho Kim +12 more
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