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Cytotoxicity of Dendrimers [PDF]
Biomolecules, 2019 Drug delivery systems are molecular platforms in which an active compound is packed into or loaded on a biocompatible nanoparticle. Such a solution improves the activity of the applied drug or decreases its side effects.
Anna Janaszewska +4 more
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Lymphocyte Cytotoxicity in vitro: Activation and Release of a Cytotoxic Factor [PDF]
Nature, 1968 WE have reported that cell contact per se is not sufficient to explain the rapid and dramatic in vitro destruction of target L cells observed when they are treated with immune lymphocytes or non-immune phytohaemagglutinin (PHA)-stimulated lymphocytes derived from various inbred mice1.
Gale A. Granger, Terry W. Williams
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High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity [PDF]
Frontiers in Immunology, 2021 Cytotoxic T lymphocytes (CTLs) are key players to eliminate tumorigenic or pathogen-infected cells using lytic granules (LG) and Fas ligand (FasL) pathways. Depletion of glucose leads to severely impaired cytotoxic function of CTLs. However, the impact of excessive glucose on CTL functions still remains largely unknown.
Jie Zhu +19 more
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Toxins, 2022 Safe working conditions must be guaranteed during waste sorting, which is crucial to maximizing recycling and reuse, in order to minimize workers’ exposure to chemical and biological hazards.
Carla Viegas +5 more
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Effect of preheating on the cytotoxicity of bulk-fill composite resins [PDF]
Journal of Dental Research, Dental Clinics, Dental Prospects, 2020 Background. Due to the effect of pre-heating on the degree of conversion of composite resins and the possible effect on cytotoxicity, the effect of pre-heating of bulk-fill composite resins was investigated on cytotoxicity in this study. Methods. In this
Mohammad Esmaeel Ebrahimi Chaharom +8 more
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Journal of Investigative Dermatology, 2006 The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Jürgen C. Becker +3 more
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Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage. [PDF]
PLoS ONE, 2017 Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U.S. Tox21 screening program, the cytotoxicity of ~10K chemicals was interrogated at 0, 8, 16, 24, 32, & 40 hours of exposure in a concentration ...
Jui-Hua Hsieh +8 more
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Antioxidants, 2022 Fumonisin B1 (FB1) is a mycotoxin that poses a great threat to agricultural production and the health of humans and animals. Pterostilbene (PTE) is a natural plant polyphenolic compound with good anti-inflammatory, antioxidant and cell regeneration ...
Jian Jin +6 more
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Relationship between localization on cellular membranes and cytotoxicity of Vibrio vulnificus hemolysin. [PDF]
PLoS ONE, 2011 Vibrio vulnificus secretes a hemolysin/cytolysin (VVH) that induces cytolysis in target cells. A detergent resistant membrane domain (DRM) fraction of the cells after sucrose gradient centrifugation includes cholesterol-rich membrane microdomains which ...
Hiroyuki Sugiyama +6 more
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Frontiers in Immunology, 2020 Background: Measurement of natural killer (NK) cell function has important clinical utility in several diseases. Although the flow cytometry (FC)-based 4-h NK cytotoxicity assay using peripheral blood mononuclear cells (PBMCs) in the clinical laboratory ...
Jinho Kim +12 more
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