Results 41 to 50 of about 805,987 (302)

Evaluation of newly synthesized schiff base Pd(II) complexes for prostate cancer treatment through in vitro cytotoxicity and molecular mechanistic studies

Frontiers in Chemistry
IntroductionPalladium (II) complexes are promising anticancer agents with potential advantages over platinum drugs. This study aimed to synthesize and characterize three new Pd(II) complexes (2a–2c) with Schiff base ligands derived from salicylic acid ...
Damnjan Pantic, Damnjan Pantic, Nikola Mirkovic, Nikola Mirkovic, Tatjana Vulovic, Tatjana Vulovic, Danijela Jovanovic, Danijela Jovanovic, Stefan Jakovljevic, Stefan Jakovljevic, Petar Canovic, Milan Zaric, Radica Zivkovic Zaric, Radica Zivkovic Zaric, Marina Kostic, Jovana Dragojevic, Vera Divac, Ziko Milanovic, Kristina Milisavljevic, Kristina Milisavljevic, Marina Mitrovic, Ivanka Zelen   +21 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Organometallic half-sandwich iridium anticancer complexes [PDF]

, 2011
The low-spin 5d6 IrIII organometallic half-sandwich complexes [(η5-Cpx)Ir(XY)Cl]0/+, Cpx = Cp*, tetramethyl(phenyl)cyclopentadienyl (Cpxph), or tetramethyl(biphenyl)cyclopentadienyl (Cpxbiph), XY = 1,10-phenanthroline (4−6), 2,2′-bipyridine (7−9 ...
Liu, Zhe, Bruijnincx, P.C.A., Brabec, V., Clarkson, Guy J., Sally A. Fletcher, Liu, Z., Vrana, O., Guy J. Clarkson, Fletcher, Sally A., Vrana, Oldrich, Salassa, Luca, Brabec, V. (Viktor), Fletcher, S.A., Kisova, A., Peter J. Sadler, Clarkson, G.J., Pizarro, A.M., Viktor Brabec, Bruijnincx, Pieter C. A., Oldrich Vrana, Sadler, P. J., Pieter C. A. Bruijnincx, Zhe Liu, Salassa, L., Luca Salassa, Habtemariam, A., Inorganic Chemistry and Catalysis, Sub Inorganic Chemistry and Catalysis, Pizarro, Ana M., Sadler, Peter J., Ana M. Pizarro, Kisova, Anna, Habtemariam, Abraha, Abraha Habtemariam, Anna Kisova   +34 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Genistein Improves the Cytotoxic, Apoptotic, and Oxidative-Stress-Inducing Properties of Doxorubicin in SK-MEL-28 Cancer Cells

Medicina
Background and Objectives: Cutaneous melanoma (CM) poses a continuous challenge in oncology due to the developing resistance to available treatments. Doxorubicin (DOX) is noted as one of the most effective chemotherapeutics, although associated toxicity ...
Andrea Roman, Andrei Motoc, Iasmina Marcovici, Cristina Dehelean, Laura Nicolescu, Casiana Boru   +5 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

The monoclonal antibody nBT062 conjugated to maytansinoids has potent and selective cytotoxicity against CD138 positive multiple myeloma cells _in vitro_ and _in vivo_ [PDF]

, 2008
CD138 (Syndecan1) is highly expressed on multiple myeloma (MM) cells. In this study, we examined the anti-MM effect of murine/human chimeric CD138-specific monoclonal antibody (mAb) nBT062 conjugated with highly cytotoxic maytansinoid derivatives _in ...
Christoph Uherek, Kenneth C. Anderson, Giulia Perrone, Yu-Tzu Tai, Paul Richardson, Hiroshi Ikeda, Robert J. Lutz, Nikhil C. Munshi, Tanyel Kiziltepe, Hiroshi Yasui, Mariateresa Fulciniti, Frank Osterroth, Yutaka Okawa, Silkie Aigner, Teru Hideshima, Loredana Santo, Sonia Vallet, Diana Cristea, Noopur S. Raje, Samantha Pozzi, Benjamin Dälken   +20 more
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