Results 21 to 30 of about 773,483 (256)

Fibril Fragmentation Enhances Amyloid Cytotoxicity [PDF]

, 2009
Fibrils associated with amyloid disease are molecular assemblies of key biological importance, yet how cells respond to the presence of amyloid remains unclear. Cellular responses may not only depend on the chemical composition or molecular properties of
Xue, Wei-Feng, Hellewell, Andrew L., Gosal, Walraj S., Hewitt, Eric W., Radford, Sheena E., Homans, Steve W.   +5 more
core   +1 more source

Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells [PDF]

, 2010
Background - Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood.
de Haan, L.H.J., Nynke M Evers, Gerrit M Alink, Marcelis, A.T.M., Alink, G.M., Antonius TM Marcelis, Evers, N.M., Xue Jiang, Laura HJ de Haan, Rietjens, I.M.C.M., Zuilhof, H., Laura H. J. DE Haan, Ivonne MCM Rietjens, Jiang, X., Sourav Bhattacharjee, Antonius T. M. Marcelis, Han Zuilhof, Haan, L.H.J., de, Nynke M. Evers, Bhattacharjee, S., Ivonne M. C. M. Rietjens, Gerrit M. Alink   +21 more
core   +1 more source

In vitro cytotoxic and antiproliferative activities of marine macroalgae from Yucatán, Mexico

Ciencias Marinas, 2009
Extracts from 27 marine algal species (14 Rhodophyta, 5 Phaeophyta, and 8 Chlorophyta) from the Yucatán Peninsula (Mexico) were evaluated for cytotoxic and antiproliferative activity by 3(4,5-dimethylthiazole-2-yl)-2,5 diphenyltetrazolium bromide (MTT ...
R Moo-Puc, D Robledo, Y Freile-Pelegrín
doaj   +1 more source

INVESTIGATION OF THE EFFECT PISTACIA VERA FROM DIFFERENT REGIONS ON OXIDATIVE STRESS AND PROLIFERATION IN BREAST CANCER CELL LINE

Sabiad, 2022
Objective: To investigate the effectiveness of extracts obtained from the inner shell of P. vera plants collected from different regions Materials and Methods: Flavanol and methanol extracts were prepared from the inner shell of P. vera.
İpek Gürkebabçı, Başak Koçdor, Hilal Koçdor   +2 more
doaj   +1 more source

Uptake and cytotoxicity of citrate-coated gold nanospheres : comparative studies on human endothelial and epithelial cells [PDF]

, 2012
The use of gold nanoparticles (AuNPs) for diagnostic applications and for drug and gene-delivery is currently under intensive investigation. For such applications, biocompatibility and the absence of cytotoxicity of AuNPs is essential. Although generally
C Kirkpatrick, Romero, Ignacio, Kirkpatrick, C. James, Weksler Babette B, Uboldi, Chiara, Gibson, Matthew I.; id_orcid, Gibson, Matthew, Kirkpatrick, C. J. (C. James), Weksler, Babette B., Freese, Christian, Unger, Ronald E., Romero Ignacio A, Kirkpatrick, James, C., Couraud, Pierre-Olivier, Kirkpatrick C, Gibson, Matthew I., Babette B Weksler, Weksler, Babette, Kirkpatrick, James,, Pierre-Olivier Couraud, Gibson Matthew I, Kirkpatrick, C. J., Couraud Pierre-Olivier, Unger Ronald E, Chiara Uboldi, Matthew I Gibson, Ignacio A Romero, Unger, Ronald, Freese Christian, Ronald E Unger, Uboldi Chiara, Romero, Ignacio A., Christian Freese   +32 more
core   +1 more source

Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity [PDF]

, 2011
Attaching peptides to metallodrugs may result in improved biological properties of the complexes. The potential use of cell penetrating peptides (CPPs) as cell delivery vectors is attractive, since directed cell uptake of (metallo)drugs remains a major ...
Rijt, Sabine H. van, Peter J. Sadler, Sadler, P. J., Hana Kostrhunova, Viktor Brabec, Brabec, V. (Viktor), Sabine H. van Rijt, Kostrhunova, Hana   +7 more
core   +1 more source

Multiparametric in vitro and in vivo analysis of the safety profile of self-assembling peptides

Scientific Reports
Self-assembling peptides (SAPs) have gained significant attention in biomedicine because of their unique properties and ability to undergo molecular self-assembly driven by non-covalent interactions.
Ariel Ramirez-Labrada, Llipsy Santiago, Cecilia Pesini, Marta Arrieta, Maykel Arias, Adanays Calvo Pérez, Maria Gessica Ciulla, Mahdi Forouharshad, Julian Pardo, Eva M. Gálvez, Fabrizio Gelain   +10 more
doaj   +1 more source

Synthesis and biological evaluation of diclofenac acid derivatives as potential lipoxygenase and α-glucosidase inhibitors

Royal Society Open Science
Inflammation is a complex physiological response associated with the onset and progression of various disorders, including diabetes. In this study, we synthesized a series of diclofenac acid derivatives and evaluated their potential anti-diabetic and ...
Asma Sardar, Obaid-ur-Rahman Abid, Wajid Rehman, Liaqat Rasheed, Mohammed M. Alanazi, Saima Daud, Muhammad Rafiq, Abdul Wadood, Muhammed Shakeel   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Cytotoxicity testing of various dentine bonding agents using human pulp fibroblast cell lines and a 3T3 mouse fibroblast cell line. [PDF]

, 2007
Philosophiae Doctor - PhDIntroduction: Biocompatibility of all kinds of dental materials is of paramount importance In order to prevent/limit irritation or degeneration of the surrounding tissues where it is applied.
Moodley, Desi
core   +1 more source