Results 21 to 30 of about 805,987 (302)

Uptake and cytotoxicity of citrate-coated gold nanospheres : comparative studies on human endothelial and epithelial cells [PDF]

, 2012
The use of gold nanoparticles (AuNPs) for diagnostic applications and for drug and gene-delivery is currently under intensive investigation. For such applications, biocompatibility and the absence of cytotoxicity of AuNPs is essential. Although generally
C Kirkpatrick, Romero, Ignacio, Kirkpatrick, C. James, Weksler Babette B, Uboldi, Chiara, Gibson, Matthew I.; id_orcid, Gibson, Matthew, Kirkpatrick, C. J. (C. James), Weksler, Babette B., Freese, Christian, Unger, Ronald E., Romero Ignacio A, Kirkpatrick, James, C., Couraud, Pierre-Olivier, Kirkpatrick C, Gibson, Matthew I., Babette B Weksler, Weksler, Babette, Kirkpatrick, James,, Pierre-Olivier Couraud, Gibson Matthew I, Kirkpatrick, C. J., Couraud Pierre-Olivier, Unger Ronald E, Chiara Uboldi, Matthew I Gibson, Ignacio A Romero, Unger, Ronald, Freese Christian, Ronald E Unger, Uboldi Chiara, Romero, Ignacio A., Christian Freese   +32 more
core   +1 more source

Cytotoxicity of enterohemorrhagic

International Journal of Medical Microbiology
The expression of Shiga toxins (Stx) is the major pathogenicity factor of enterohemorrhagic Escherichia coli (EHEC). Stx structurally consist of one enzymatically active A-subunit (StxA) and a pentamer of non-covalently linked B-subunits (StxB).
Katrin Neudek, Melina Geissler, Irina König, Danielle Blum, Panagiotis Papatheodorou, Holger Barth, Herbert Schmidt   +6 more
doaj   +1 more source

Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity [PDF]

, 2011
Attaching peptides to metallodrugs may result in improved biological properties of the complexes. The potential use of cell penetrating peptides (CPPs) as cell delivery vectors is attractive, since directed cell uptake of (metallo)drugs remains a major ...
Rijt, Sabine H. van, Peter J. Sadler, Sadler, P. J., Hana Kostrhunova, Viktor Brabec, Brabec, V. (Viktor), Sabine H. van Rijt, Kostrhunova, Hana   +7 more
core   +1 more source

Multiparametric in vitro and in vivo analysis of the safety profile of self-assembling peptides

Scientific Reports
Self-assembling peptides (SAPs) have gained significant attention in biomedicine because of their unique properties and ability to undergo molecular self-assembly driven by non-covalent interactions.
Ariel Ramirez-Labrada, Llipsy Santiago, Cecilia Pesini, Marta Arrieta, Maykel Arias, Adanays Calvo Pérez, Maria Gessica Ciulla, Mahdi Forouharshad, Julian Pardo, Eva M. Gálvez, Fabrizio Gelain   +10 more
doaj   +1 more source

Production of dry toast slices with high nutritional value and attractive color using red beet, spinach, or carrot pastes [PDF]

Food Technology Research Journal
Vegetables are essential dietary components, providing a wealth of nutrients, particularly minerals and fiber. This research aimed to enhance dry toast slices' nutritional value and visual appeal by incorporating red beet, spinach, or carrot paste as ...
Ghada, M. Youssef, Ayat, E. Rizk, Akram, M.M. Elanany, Ahmad, E. Abdel Gawad   +3 more
doaj   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Use of in vitro human keratinocyte models to study the effect of cooling on chemotherapy drug-induced cytotoxicity [PDF]

, 2014
A highly distressing side-effect of cancer chemotherapy is chemotherapy-induced alopecia (CIA). Scalp cooling remains the only treatment for CIA, yet there is no experimental evidence to support the cytoprotective capacity of cooling. We have established
van den Hurk, Corina J., Komen, Manon M., Hussain, Omar, Dunnill, Christopher, Georgopoulos, Nikolaos T., Al-Tameemi, Wafaa, Collett, Andrew   +6 more
core   +1 more source

Cellular Entry, Cytotoxicity, and Antifungal Activity of Newly Synthesized Dendrimers

Applied Sciences
Dendrimers, 4-dimethylamino-1,8-naphthalimide (DAB) and its halogenated analog 3-bromo-4-dimethylamino-1,8-naphthalimide (DAB-Br), were evaluated on eukaryotic cells, human HFF-1 fibroblast cells, and five fungal species.
Aneliya Kostadinova, Ema Gaydarska, Tanya Topouzova-Hristova, Dayana Benkova, Galya Staneva, Ekaterina Krumova, Rusina Hazarosova, Miroslav Marinov, Asya Tsanova, Albena Jordanova, Ivo Grabchev   +10 more
doaj   +1 more source

A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity

Journal of Biological Chemistry, 1993
Onconase, or P-30, is a protein initially purified from extracts of Rana pipiens oocytes and early embryos based upon its anticancer activity both in vitro and in vivo. It is a basic single-chain protein with an apparent molecular mass of 12,000 daltons and is homologous to RNase A.
Y, Wu, S M, Mikulski, W, Ardelt, S M, Rybak, R J, Youle   +4 more
openaire   +2 more sources

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source