Results 51 to 60 of about 709,234 (313)

Cytotoxicity induced by Aeromonas schubertii is orchestrated by a unique set of type III secretion system effectors

Veterinary Research
The type III secretion system (T3SS) is an important virulence factor of Gram-negative bacteria, including the genus Aeromonas, which represents a diverse group of aquatic bacteria.
Hana Michova, Jan Pliva, Anezka Jirsova, David Jurnecka, Jana Kamanova   +4 more
doaj   +1 more source

Phytochemical Screening and Biological Activities of Lippia multiflora Moldenke

Molecules
Lippia multiflora Moldenke is widely used in Angola, on the African continent, and beyond for the treatment of many health conditions such as hypertension, enteritis, colds, gastrointestinal disturbances, stomachaches, jaundice, coughs, fevers, nausea ...
Dorcas Tlhapi, Ntsoaki Malebo, Idah Tichaidza Manduna, Monizi Mawunu, Ramakwala Christinah Chokwe   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Understanding of black salve toxicity by multi-compound cytotoxicity assays

, 2022
BACKGROUND: Black salve is a controversial complementary and alternative medicine (CAM) associated with skin toxicity and skin cancer treatment failures.
Myers, SP, Myers, Stephen P., Croaker, Andrew, Carroll, Anthony, Davis, Arie, Myers, Stephen P. (R18994), Carroll, A, Croaker, A, Liu, L, Liu, Lei, Davis, A   +10 more
core   +1 more source

Dianthus superbus L. (QM) Extract-Assisted Silver Nanoparticle Gelatin Films with Antioxidant and Antimicrobial Properties for Fresh Fruit Preservation

Foods
We synthesized QM-AgNPs (Dianthus superbus L.-AgNPs, Qu Mai-AgNPs) by an economical and environmentally friendly method using Dianthus superbus L. extract as a reducing and stabilizing agent.
Chenwei Zhang, Yao Li, Yue Huo, Hongtao Wang, Dandan Wang   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Conversion of a Short Lipopeptoid into Longer Non-lipidated Repeat Peptoids with Improved Activity

, 2021
The need for new antibiotics to treat antibiotic resistant bacteria has been a growing problem worldwide over the past several years. Bacteria are quickly developing modifications to render antibiotics useless due to overuse and misuse of medications ...
Tran, Mary Ngoc
core  

Cytotoxicity and physicochemical characterization of iron–manganese-doped sulfated zirconia nanoparticles [PDF]

, 2015
Iron–manganese-doped sulfated zirconia nanoparticles with both Lewis and Brønsted acidic sites were prepared by a hydrothermal impregnation method followed by calcination at 650°C for 5 hours, and their cytotoxicity properties against cancer cell lines ...
Al-Fahdawi, Mohamed Qasim, Rasedee, Abdullah, Abdullah, Rasedee, Rosli, Rozita, El Zowalaty, Mohamed Ezzat, Al-Qubaisi, Mothanna Sadiq, Taufiq-Yap, Yun Hin, Alhassan, Fatah H., Naadja, Seif-Eddine, Webster, Thomas J.   +9 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source