Results 61 to 70 of about 709,234 (313)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Assessment of Potential Toxic Effects of Fungicide Fludioxonil on Human Cells and Aquatic Microorganisms

Toxics
Fludioxonil is a widely used fungicide that is frequently used to combat fungal plant diseases. Consequently, excessive concentrations of fludioxonil may enter and accumulate over time in aquatic systems, harming (micro) organisms in several ways.
Maria Antonopoulou, Anna Tzamaria, Sotiris Papas, Ioanna Efthimiou, Dimitris Vlastos   +4 more
doaj   +1 more source

Antiradical Activities and Cytotoxic Effects of Phlomis Brevibracteata Turrill on SK-HEP-1 Adenocarcinoma Cell Line

Proceedings, 2018
The present study investigates the total phenol amount, radical scavenging and anticancer activity of methanolic extract of Phlomis brevibracteata Turrill (PBT) leaves; an endemic plant of North Cyprus.
Imge Kunter, Niloofar Zabib, Kelly Randmae, Mahshid Dabeshlim, Muberra Kosar   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cytotoxicity Test of Sponge Amnion on BHK-21 Fibroblast Cell [PDF]

, 2018
Biomaterials that can be used to accelerate wound healing is the amniotic membrane that contains growth hormone. In its use, amniotic membrane tends to be difficult to use because of their sheets form.
Anita Yuliati, Annisa Noor Ragilia, Elly Munadziroh   +2 more
core  

Enhancing Antioxidant and Cytotoxic Properties of CeO₂ Through Silver Decoration: A Study on Ag@CeO₂ Nanocomposites

Nanomaterials
In this study, silver-decorated cerium oxide (Ag@CeO2) nanoparticles were synthesized through a simple mixing and pyrolysis process to enhance their antioxidant and antitumor properties.
Chen Yang, Jingjing He, Siying Chen, Qiuping Li, Xuexia Lin   +4 more
doaj   +1 more source

Evaluation of In Vitro Anti-Proliferative Activity of St. John’s Wort (Hypericum perforatum Linn.) Plant Extract on Cervix Adenocarcinoma

Proceedings, 2017
St. John’s wort (Hypericum perforatum L.) is a medicinal plant used for many diseases. Hypericum perforatum has strong historical background about the therapeutic potential.
Rana Kavurmacı, Serap Yalcin
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Identification of the Cytotoxic Transglutaminase from Mycobacterium spp. That Is Involved in RIPK1 Activation

Molecules
Although the global incidence of tuberculosis has declined in recent years, tuberculosis remains a major global public health challenge. The Mycobacterium tuberculosis complex (MTBC) including M. tuberculosis, M. bovis, M. microti, etc., is the deadliest
Xinting Zhang, Yikai Zhang, Xiao Feng, Yueying Wang, Si-Shang Li, Mei-Yi Yan, Yi-Cheng Sun, Qi Jin, Feng Jiang   +8 more
doaj   +1 more source

Antioxidant Properties and Cytoprotective Effect Against H₂O₂-Induced Cytotoxicity in Mouse Fibroblasts Cells (L-929) of Horseradish Leaves

Proceedings, 2019
Horseradish (Armoracia rusticana L.) is a perennial plant from the Brassicaceae family native toEurope and Asia, and globally widespread through cultivation [...]
Ramona-Daniela Păvăloiu, Fawzia Sha’at, Corina Bubueanu, Georgeta Neagu, Cristina Hlevca, Mousa Sha’at, Gheorghe Nechifor   +6 more
doaj   +1 more source