Results 131 to 140 of about 34,355 (311)

Single-cell RNA sequencing uncovers heterogenous immune cell responses upon exposure to food additive (E171) titanium dioxide

Journal of Nanobiotechnology
The prospective use of food additive titanium dioxide (E171 TiO2) in a variety of fields (food, pharmaceutics, and cosmetics) prompts proper cellular cytotoxicity and transcriptomic assessment.
Haribalan Perumalsamy, Xiao Xiao, Hyoung-Yun Han, Jung-Hwa Oh, Seokjoo Yoon, Min Beom Heo, Tae Geol Lee, Hyun-Yi Kim, Tae-Hyun Yoon   +8 more
doaj   +1 more source

Epitope-level analysis of cross-reactive human HLA antibodies against genetically modified swine leukocyte antigens in xenotransplantation

Frontiers in Immunology
IntroductionXenotransplantation using genetically modified pigs is a promising solution to organ shortages, particularly for highly sensitized patients with broad anti-HLA sensitization who lack compatible allografts.
Sang-Ik Cho, Ji-Jing Yan, Beom Seok Kim, Beom Seok Kim, Nayoung Ko, Joohyun Shim, Hyunil Kim, Eun-Jee Oh, Eun-Jee Oh   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

High-dose survival in the lymphocytic choriomeningitis virus infection is accompanied by suppressed DTH but unaffected T-cell cytotoxicity [PDF]

, 1985
Udgivelsesdato: 1985-JanProvided that intracerebral inoculation is applied, an increase in the virus dose from 10(2) to 10(4) LD50 of lymphocytic choriomeningitis virus (LCMV) leads to strikingly reduced mortality.
Thomsen, Allan Randrup, Clemmensen, I H, Hansen, B L, Marker, O, Volkert, M   +4 more
core  

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Paclitaxel Modulates the Proliferation and Differentiation of THP-1 Cells Exposed to Inactivated SARS-CoV-2 Virus

Revista Brasileira de Cancerologia
Introduction: Cancer patients were considered a high-risk group for COVID-19. Studies indicate that certain types of cancer, as breast cancer, may exhibit distinct immunological responses.
Everaldo Hertz, Bárbara Osmarin Turra, Nathália Cardoso de Afonso Bonotto, Fernanda dos Santos Trombini, João Arthur Bittencourt Zimmermann, Cibele Ferreira Teixeira, Verônica Farina Azzolin, Ivo Emilio da Cruz Jung, Ivana Beatrice Mânica da Cruz, Fernanda Barbisan   +9 more
doaj   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Natural killer cell granule protein 7 contributes to CD8+ T cell-mediated platelet apoptosis in immune thrombocytopenia

Research and Practice in Thrombosis and Haemostasis
Background: CD8+ T cells participate in the pathogenesis of primary immune thrombocytopenia (ITP). Natural killer cell granule protein 7 (NKG7) is essential for natural killer cell and CD8+ T cell cytotoxicity. The function of NKG7 in CD8+ T cells in ITP
Xiaolin Wang, Qiang Liu, Xiaojing Li, Wei Xing, Ping Chen, Qi Feng, Ming Hou, Qian Wang, Hai Zhou, Jun Peng   +9 more
doaj   +1 more source