Results 271 to 280 of about 906,600 (363)

An Off‐the‐Shelf Artificial Blood Clot Hydrogel Neutralizing Multiple Proinflammatory Mediators for Pro‐Regenerative Periodontitis Treatment

Advanced Science, EarlyView.
CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Tingting Lan, Yonglan Wang, Chenxuan Wu, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Anjie Dong, Zujian Feng, Deling Kong, Weiwei Wang   +14 more
wiley   +1 more source

Luteolin as an adjuvant effectively enhanced the efficacy of adoptive tumor-specific CTLs therapy. [PDF]

BMC Cancer
Lai Z, Pang Y, Zhou Y, Chen L, Zheng K, Yuan S, Wang W.   +6 more
europepmc   +1 more source

A pH‐Sensitive Nanosized Covalent–Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition

Advanced Science, EarlyView.
The nanosized covalent organic polymer composed of photosensitizer porphyrin, pyruvate kinase inhibitor vitamin K3, and STAT3 inhibitor WP1066 is prepared for enhanced photodynamic immunotherapy by simultaneous hypoxia relief and STAT3 inhibition. Abstract Photodynamic therapy (PDT) is a promising cancer therapy modality by generating reactive oxygen ...
Lei Lei, Wenbin Dai, Jinchao Zhao, Angfeng Jiang, Haisheng Peng, Qiao Jin, Xiaojing Li, Zhe Tang   +7 more
wiley   +1 more source

Enhanced cytotoxicity of aging associated NKG2C + CD8 + T cells in ankylosing spondylitis via HLA-B27. [PDF]

Arthritis Res Ther
Tang K, Ma X, Gao J, Zu L, Ma Y, Zhuo D, Wu C, Tang Y, Qian F, Jin L, Wang J, Zhu Q, Liu J.   +12 more
europepmc   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

CAR-T Entering a New "Phase": Improving CAR-T Function by Harnessing Phase Separation. [PDF]

Cancer Res
Su X.
europepmc   +1 more source

Modulation of natural killer cell‐mediated cytotoxicity by tamoxifen and estradiol

Cancer, 1995
E. Baral, É. Nagy, I. Bérczi
semanticscholar   +1 more source

Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy

Advanced Science, EarlyView.
Cryo‐inactivated cancer cell‐based magnetic micromotors are developed for synergistic tumor immunotherapy via magnetic targeting. These micromotors can induce ferroptosis and immunogenic cell death, deliver tumor antigens, and activate the Mn2+‐dependent cGAS‐STING pathway. The system effectively suppresses tumor progression, recurrence, and metastasis,
Qingfei Zhang, Gaizhen Kuang, Wenzhao Li, Yuanjin Zhao   +3 more
wiley   +1 more source

Protocol for assessing immune-target cell interactions using a single-cell cytotoxicity assay. [PDF]

STAR Protoc
Wei Z, Lin K, Huang M, Su S, Lu Y.
europepmc   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source