CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse [PDF]
Scientific Reports, 2019 AbstractWe examined the potential value of the natural killer (NK) cell line; NK-92, as immunotherapy tool for breast cancer (BC) treatment and searched for biomarker(s) of sensitivity to NK-92-mediated cytotoxicity. The cytotoxic activity of NK-92 cells towards one breast precancerous and nine BC cell lines was analyzed using calcein-AM and ...
Taouk G. +6 more
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Function-specific variations in the immunological synapses formed by cytotoxic T cells [PDF]
Proceedings of the National Academy of Sciences, 2003 CD8+ cytotoxic T lymphocytes (CTLs) provide defense against intracellular pathogens and tumors by recognizing and subsequently destroying infected or transformed cells. Recognition is achieved by T cell receptors (TCRs) on the CTL binding to non-self-peptide fragments presented in the cleft of class I MHC molecules (peptide–MHC complexes) on the ...
openaire +3 more sources
Cytotoxicity of polycarbonate orthodontic brackets
Brazilian Journal of Oral Sciences, 2015 Aim: To assess the cytotoxicity of polycarbonate orthodontic brackets. Methods: Polycarbonate brackets from two different manufacturers, namely, Composite bracket (Morelli™) and Silkon Plus bracket (American Orthodontics™), were assessed.
Matheus Melo Pithon +6 more
doaj +1 more source
CD40L expression permits CD8+ T cells to execute immunologic helper functions.
Blood, 2013 CD8(+) T cells play an essential role in immunity against intracellular pathogens, with cytotoxicity being considered their major effector mechanism. However, we here demonstrate that a major part of central and effector memory CD8(+) T cells expresses ...
M. Frentsch +13 more
semanticscholar +1 more source
Phytochemical study and evaluation of the cytotoxic properties of methanolic extract from Baccharis obtusifolia [PDF]
International Journal of Medicinal Chemistry, 2018, 2019 Some species of the Baccharis genus have been shown to possess important biomedical properties, including cytotoxic activity. In this study, we examined the cytotoxic effect of methanol extract from Baccharis obtusifolia (Asteraceae) in cancer cell lines of prostate (PC-3), colon (RKO), astrocytoma (D-384), and breast (MCF-7).
arxiv +1 more source
<i>In vitro</i> comparison of antioxidant, cytotoxic, and antibacterial (against <i>Aggregatibacter actinomycetemcomitans</i>) effects of <i>Citrus reticulata</i>, <i>Olea europaea</i> extracts, and essential oils. [PDF]
Dent Res J (Isfahan)Background: This study compared the antioxidant, cytotoxic, and antibacterial effects of Citrus reticulata (C. reticulata) peel and Olea europaea (O. europaea) leaf hydroalcoholic extracts and essential oils. Materials and Methods: In this in vitro study,
Vahabi S, Torshabi M, Mirsharif SZ.
europepmc +2 more sources
The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity [PDF]
Cell Reports, 2019 Cytotoxic immunoglobulin G antibodies are an essential component of therapeutic approaches aimed at depleting self-reactive or malignant cells. More recent evidence suggests that the tissue in which the target cell resides influences the underlying molecular and cellular pathways responsible for cytotoxic antibody activity.
Heike Danzer +5 more
openaire +4 more sources
Journal of Orofacial Sciences, 2019 Introduction: Although physical and mechanical properties are extremely important for the effectiveness of prosthetic treatment, materials used for facial rehabilitation should be biocompatible, as the maxillofacial prosthesis is in close contact with ...
Marcelo Coelho Goiato +4 more
doaj +1 more source
Genetic Modification of Limbal Stem Cells to Decrease Allogeneic Immune Responses
Frontiers in Immunology, 2021 Limbal stem cell (LSC) transplantation is the only efficient treatment for patients affected by LSC deficiency (LSCD). Allogeneic LSC transplantation is one of the most successful alternative for patients with bilateral LSCD.
Emilio Valdivia +9 more
doaj +1 more source
Sensing Danger: Innate Immunology for Intrusion Detection [PDF]
Information Security Technical Report, 12(4), pp 218-227, 2007, 2008 The immune system provides an ideal metaphor for anomaly detection in general and computer security in particular. Based on this idea, artificial immune systems have been used for a number of years for intrusion detection, unfortunately so far with little success. However, these previous systems were largely based on immunological theory from the 1970s
arxiv +1 more source