Results 81 to 90 of about 937,918 (334)
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source
Combined liver-kidney transplantation: Analysis of patients with preformed lymphocytotoxic antibody [PDF]
, 1988 In this report, we address combined liver-kidney transplantation, with particular attention to the apparent phenomenon of protection of kidney allografts to antibody mediated destruction by liver allografts.
Duquesnoy, R +8 more
core
Trypsin digest of cancer cells surface stimulates anti-tumor immune response better than cancer cells themselves [PDF]
, 2010 Antigens expressed on the surface of cancer cells are accessible targets for both humoral and cell-mediated immune responses, and are therefore potential candidates for vaccine development.
Balashova Elena, Petr Lokhov
core +2 more sources
Post‐COVID Fatigue Is Associated With Reduced Cortical Thickness After Hospitalization
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuropsychiatric symptoms are among the most prevalent sequelae of COVID‐19, particularly among hospitalized patients. Recent research has identified volumetric brain changes associated with COVID‐19. However, it currently remains poorly understood how brain changes relate to post‐COVID fatigue and cognitive deficits.
Tim J. Hartung +190 more
wiley +1 more source
Acta Scientiarum. Health Sciences, 2015 While a 42-year-old male patient was being prepared for deceased-donor renal transplantation, anti-HLA-A2 antibodies were detected in the serum by enzyme-linked immunosorbent assay (ELISA) method.
Hugo Mendonça Mundim +5 more
doaj +1 more source
Granulocyte-activating mediators (GRAM) [PDF]
, 1988 In the present study we investigated the capability of human epidermal cells to generate granulocyte-activating mediators (GRAM). It could be shown that human epidermal cells as well as an epidermoid carcinoma cell line (A431) produce an epidermal cell ...
Kapp, A. +3 more
core +1 more source
Function-specific variations in the immunological synapses formed by cytotoxic T cells [PDF]
Proceedings of the National Academy of Sciences, 2003 CD8+ cytotoxic T lymphocytes (CTLs) provide defense against intracellular pathogens and tumors by recognizing and subsequently destroying infected or transformed cells. Recognition is achieved by T cell receptors (TCRs) on the CTL binding to non-self-peptide fragments presented in the cleft of class I MHC molecules (peptide–MHC complexes) on the ...
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo +9 more
wiley +1 more source
Natural Killer cells responsiveness to physical esercise: a brief review [PDF]
, 2013 Natural killer cells (NK) are a group of peripheral blood lymphocytes which display cytotoxic ac- tivity against a wide range of tumour cells. They are a consistent part of the inflammatory re- sponse that is activated when either internal or external ...
Concu A. +4 more
core +1 more source