Results 31 to 40 of about 686,731 (316)
Toxicity profiling of engineered nanomaterials via multivariate dose-response surface modeling [PDF]
Annals of Applied Statistics 2012, Vol. 6, No. 4, 1707-1729, 2013 New generation in vitro high-throughput screening (HTS) assays for the assessment of engineered nanomaterials provide an opportunity to learn how these particles interact at the cellular level, particularly in relation to injury pathways. These types of assays are often characterized by small sample sizes, high measurement error and high dimensionality,
arxiv +1 more source
Cytotoxicity of etietinate and vindesine [PDF]
Journal of Ethnopharmacology, 1985 The effects of an aromatic retinoid, etretinate and a vinca alkaloid, vindesine were investigated by culture of malignant melanoma cells in vitro with these two agents; either separately or in combination. Etretinate inhibited growth of a murine melanoma but only minimal effects were recorded with two human melanomas.
L Wilson, MacKie Rm, J M Gaukroger
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Cytotoxicity and Genotoxicity of Nanomaterials [PDF]
Nanomaterials, 2022 Nanomaterials (NMs) are of significant relevance due to their unique physicochemical properties, which have been extensively exploited for widespread applications in human healthcare and consumer goods, such as cosmetics and textiles [...]
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Cytotoxicity of Ceramic Materials
Česká Stomatologie a Praktické Zubní Lékařství, 2011 Paper presents cytotoxicity testing procedure in vitro of preselected dental ceramics. Direct contact test and extract test were monitored. A population of mouse fibroblasts NIH 3T3 was used for both tests.
L. Vavřičková +2 more
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Enhanced cytotoxicity of auraptene to prostate cancer cells by dextran-coated Fe3O4 nanoparticles [PDF]
Nanomedicine Journal, 2022 Purpose: Auraptene (AUR) is a monoterpene coumarin compound with several biological activities specifically anti-cancer. The bioavailability of AUR in biological fluids is negligible, thus, the cytotoxicity of this compound for the target cells is low ...
Narges Naseri +4 more
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A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity
Journal of Biological Chemistry, 1993 Onconase, or P-30, is a protein initially purified from extracts of Rana pipiens oocytes and early embryos based upon its anticancer activity both in vitro and in vivo. It is a basic single-chain protein with an apparent molecular mass of 12,000 daltons and is homologous to RNase A.
Stanislaw M. Mikulski +4 more
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Toxics, 2020 Benzalkonium chloride (BAC), an antimicrobial agent in inhalable medications and household sprays, has been reported to be toxic to pulmonary organs.
Sou Hyun Kim +7 more
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Journal of Experimental Medicine, 2017 It is unclear whether PD-L1 on tumor cells is sufficient for tumor immune evasion or simply correlates with an inflamed tumor microenvironment. We used three mouse tumor models sensitive to PD-1 blockade to evaluate the significance of PD-L1 on tumor ...
Vikram R. Juneja +7 more
semanticscholar +1 more source
Cytotoxic immunological synapses [PDF]
Immunological Reviews, 2010 Summary: One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the ...
Dustin, M, Long, E
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Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction
Molecules, 2020 This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53– Mouse double minute 2 homolog (MDM2) protein–protein interaction.
Anastasia Beloglazkina +3 more
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