Results 31 to 40 of about 1,197,953 (344)

In vitro Anticancer Activity of the Polar Fraction From the Lophocereus schottii Ethanolic Extract

Frontiers in Pharmacology, 2022
Cancer is an increasingly common disease and is considered one of the main causes of death in the world. Lophocereus schottii (L. schottii) is a cactus used in Mexico in traditional medicine for cancer treatment.
Arturo Orozco-Barocio, Blanca Susana Robles-Rodríguez, María del Rayo Camacho-Corona, Luis Fernando Méndez-López, Marisol Godínez-Rubí, Jorge Peregrina-Sandoval, Gildardo Rivera, Argelia E. Rojas Mayorquín, Daniel Ortuno-Sahagun   +8 more
doaj   +1 more source

The Natural Cytotoxicity Receptors in Health and Disease

Frontiers in Immunology, 2019
The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted recognition of tumor cells to be cloned over 20 years ago.
A. Barrow, C. Martin, M. Colonna
semanticscholar   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing

Journal of Experimental Medicine, 2019
Natural killer cells can kill infected and transformed cells via two different cell death mechanisms. Prager et al. show that NK cells quickly kill their first targets by releasing cytotoxic granules and only use the slower death receptor–mediated ...
I. Prager, C. Liesche, Hanna van Ooijen, D. Urlaub, Quentin Verron, N. Sandström, Frank Fasbender, M. Claus, R. Eils, J. Beaudouin, B. Önfelt, C. Watzl   +11 more
semanticscholar   +1 more source

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Phenotypical Diversification of Early IFNα-Producing Human Plasmacytoid Dendritic Cells Using Droplet-Based Microfluidics

Frontiers in Immunology, 2021
Plasmacytoid dendritic cells (pDCs) are a rare type of highly versatile immune cells that besides their specialized function of massive type I interferon (IFN-I) production are able to exert cytotoxic effector functions.
Laura C. Van Eyndhoven, Laura C. Van Eyndhoven, Eleni Chouri, Eleni Chouri, Nikita Subedi, Nikita Subedi, Jurjen Tel, Jurjen Tel   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Novel Effective Bacillus cereus Group Species “Bacillus clarus” Is Represented by Antibiotic-Producing Strain ATCC 21929 Isolated from Soil

mSphere, 2020
Gram-positive, spore-forming members of the Bacillus cereus group species complex are widespread in natural environments and display various degrees of pathogenicity. Recently, B.
Marysabel Méndez Acevedo, Laura M. Carroll, Manjari Mukherjee, Emma Mills, Lingzi Xiaoli, Edward G. Dudley, Jasna Kovac   +6 more
doaj   +1 more source

Comparison of Cytotoxicity Evaluation of Anticancer Drugs between Real-Time Cell Analysis and CCK-8 Method

ACS Omega, 2019
Critical cytotoxicity evaluation of pharmaceuticals is necessary for the clinical practice of chemotherapy. To quantitatively evaluate cell viability, currently there are two main types of sensitive methods including real-time cell analysis (RTCA) and ...
Ling Cai, Xijiang Qin, Zhihui Xu, Yiyan Song, Hui-jun Jiang, Yuan Wu, Hongjie Ruan, Jin Chen   +7 more
semanticscholar   +1 more source