Results 61 to 70 of about 1,019,504 (340)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Use of in vitro human keratinocyte models to study the effect of cooling on chemotherapy drug-induced cytotoxicity [PDF]

, 2014
A highly distressing side-effect of cancer chemotherapy is chemotherapy-induced alopecia (CIA). Scalp cooling remains the only treatment for CIA, yet there is no experimental evidence to support the cytoprotective capacity of cooling. We have established
Andrew Collett, Bodo, Boelsma, Boukamp, Breed, Brunsvig, Bulow, Christopher Dunnill, Corina J. van den Hurk, Dean, Deyrieux, Georgopoulos, Gregory, Grevelman, Inui, Itami, Itoh, Janssen, Janssen, Kayamba, Komen, Lane, Liu, Luanpitpong, Manon M. Komen, Margulis, Munstedt, Nabholtz, Nikolaos T. Georgopoulos, Omar Hussain, Paus, Protiere, Roh, van den Hurk, Wafaa Al-Tameemi, Wang, Watanabe   +36 more
core   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Silver Nanoparticles Functionalized With Antimicrobial Polypeptides: Benefits and Possible Pitfalls of a Novel Anti-infective Tool

Frontiers in Microbiology, 2021
Silver nanoparticles (AgNPs) and antimicrobial peptides or proteins (AMPs/APs) are both considered as promising platforms for the development of novel therapeutic agents effective against the growing number of drug-resistant pathogens.
Maria S. Zharkova, Olga Yu. Golubeva, Dmitriy S. Orlov, Elizaveta V. Vladimirova, Alexander V. Dmitriev, Alessandro Tossi, Olga V. Shamova   +6 more
doaj   +1 more source

Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines. [PDF]

, 1987
After culture in IL-2, thymocytes expressing either TCR-alpha/beta or -gamma/delta acquired the ability to lyse hematopoietic and solid tumor cell targets without deliberate immunization or apparent restriction by the MHC.
Gemlo, BT, Lanier, LL, Phillips, JH, Rayner, AA, Weiss, A   +4 more
core   +1 more source

Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency [PDF]

, 2014
Defects in perforin lead to the failure of T and NK cell cytotoxicity, hypercytokinemia, and the immune dysregulatory condition known as familial hemophagocytic lymphohistiocytosis (FHL).
Alonso-Ferrero, ME, Arumugam, P, Baum, C, Blundell, MP, Carmo, M, Gaspar, HB, Hontz, AE, Jordan, MB, Malik, P, Montiel-Equihua, CA, Risma, KA, Schambach, A, Thrasher, AJ, Tiwari, S   +13 more
core   +2 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Cytotoxicity evaluation of Dionysia revoluta Boiss. on VERO and Hep-2c cell lines [PDF]

Research Journal of Pharmacognosy, 2017
Background and objectives: Evaluating the safety of pharmaceutical products by in vitro methods like cell culture, and in vivo tests on animals, is one of the regulatory steps in development of drugs which is called the preclinical stage.
A. Mirmoini, N. Rahimifard, F. Mojab, F. Bagheri, SR. Pakzad*   +4 more
doaj  

Relapse Following Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia Apparently Due to Somatic Cell Evolution via Epigenetic Variation and Immune Selection

Pathogens and Immunity, 2019
In this brief commentary, I discuss a recently published study that documents the role of immune escape in relapse of acute myeloid leukemia (AML) after hematopoietic cell transplantation (HCT).
Neil S. Greenspan
doaj   +1 more source

The cytotoxicity of fatty acid/α-lactalbumin complexes depends on the amount and type of fatty acid [PDF]

, 2013
peer-reviewedComplexes of the milk protein, α-lactalbumin, and the fatty acid, oleic acid, have previously been shown to be cytotoxic. Complexes of α-lactalbumin and five different fatty acids (vaccenic, linoleic, palmitoleic, stearic, and elaidic acid ...
Aits, Andrade, Barbana, Brinkmann, Brinkmann, Budavari, Cury, de Lima, Düringer, Fischer, Gustafsson, Gustafsson, Hallgren, Kehoe, Knyazeva, Kohler, Lima, Liskova, Lišková, Mossberg, Mossberg, Mossberg, Nielsen, Permyakov, Permyakov, Pettersson, Pettersson-Kastberg, Rammer, Spolaore, Svanborg, Svensson, Svensson, Tolin, van Engeland, Vukojevic, Wilhelm   +35 more
core   +1 more source