Results 61 to 70 of about 1,197,953 (344)

Chemical Composition and Anti-Lung Cancer Activities of Melaleuca quinquenervia Leaf Essential Oil: Integrating Gas Chromatography–Mass Spectrometry (GC/MS) Profiling, Network Pharmacology, and Molecular Docking

Pharmaceuticals
Background/Objectives: This study investigates the phytochemical composition and anticancer activity of Melaleuca quinquenervia leaf essential oil (MQLEO) from Egypt. Methods: Chemical profiling was performed using GC/MS. Anticancer activity was assessed
Eman Fikry, Raha Orfali, Shagufta Perveen, Safina Ghaffar, Azza M. El-Shafae, Maher M. El-Domiaty, Nora Tawfeek   +6 more
doaj   +1 more source

Design, Synthesis and Study of Antibacterial and Antitubercular Activity of Quinoline Hydrazone Hybrids

Heterocyclic Communications, 2020
Emerging bacterial resistance is causing widespread problems for the treatment of various infections. Therefore, the search for antimicrobials is a never-ending task. Hydrazones and quinolines possess a wide variety of biological activities.
T G Shruthi, Subramanian Sangeetha, Eswaran Sumesh   +2 more
doaj   +1 more source

Impact of gold nanoparticles shape on their cytotoxicity against human osteoblast and osteosarcoma in in vitro model. Evaluation of the safety of use and anti-cancer potential

Journal of Materials Science: Materials in Medicine, 2019
Due to development of nanotechnology and gold nanoparticles (AuNPs) increasing use in different areas of medicine, especially in oncology, better understanding of their potential cytotoxicity is necessary to protect patients safety.
Karol P. Steckiewicz, Ewelina Barcińska, Anna Malankowska, A. Zauszkiewicz-Pawlak, G. Nowaczyk, A. Zaleska-Medynska, I. Inkielewicz-Stępniak   +6 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

PEGylated Liposomes of Disulfiram and Paclitaxel: A Promising Chemotherapeutic Combination Against Chemoresistant Breast Cancer

Pharmaceuticals
Background: Steric stabilization of liposomes using PEGylation has been used widely in pharmaceutical research to overcome the limitations of conventional liposomes and to extend circulation time.
Ammar Said Suliman, Sahrish Rehmani, Benjamin Small, Kate Butcher, Mouhamad Khoder, Vinodh Kannappan, Weiguang Wang, Abdelbary Elhissi, Mohammad Najlah   +8 more
doaj   +1 more source

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning [PDF]

, 2020
Peter M. Bruno, Mengrou Lu, Kady A. Dennis, Haider Inam, Connor J. Moore, John Sheehe, Stephen J. Elledge, Michael T. Hemann, Justin R. Pritchard   +8 more
openalex   +1 more source

Composition-Dependent Cytotoxic and Antibacterial Activity of Biopolymer-Capped Ag/Au Bimetallic Nanoparticles against Melanoma and Multidrug-Resistant Pathogens [PDF]

, 2022
Alfonso Nieto-Argüello, David Medina-Cruz, Yeremi Pérez, Sergio Alfonso Pérez‐García, Miguel Ángel Velasco‐Soto, Zeinab Jafari, Israel De Leon, Marı́a Ujué González, Yves Huttel, L. Martı́nez, Álvaro Mayoral, Thomas J. Webster, José Miguel García‐Martín, Jorge L. Cholula‐Díaz   +13 more
openalex   +1 more source

Integrated drug profiling and CRISPR screening identify essential pathways for CAR T cell cytotoxicity.

Blood, 2019
Chimeric antigen receptor (CAR) T cell therapy has proven effective in relapsed and refractory B cell malignancies, but resistance and relapses still occur.
O. Dufva, J. Koski, Pilvi Maliniemi, A. Ianevski, J. Klievink, J. Leitner, P. Pölönen, Helena R Hohtari, K. Saeed, T. Hannunen, P. Ellonen, P. Steinberger, M. Kankainen, T. Aittokallio, Mikko A. I. Keränen, M. Korhonen, S. Mustjoki   +16 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

In Vitro Cytotoxicity Evaluation of Nanosized Hydroxyapatite and Fluorapatite on Cell Lines and Their Relevance to the Alveolar Augmentation Process

Journal of Functional Biomaterials
Background/Objectives: Materials with an apatite structure were investigated in vitro in dental bone augmentation procedures. This scientific study aimed to compare nanosized hydroxyapatite (nHAp) and fluorapatite (nFAp) materials in the form of tablets ...
Wojciech Zakrzewski, Maria Szymonowicz, Anna Nikodem, Agnieszka Rusak, Zbigniew Rybak, Katarzyna Szyszka, Dorota Diakowska, Benita Wiatrak, Rafal J. Wiglusz, Maciej Dobrzyński   +9 more
doaj   +1 more source