Results 71 to 80 of about 686,731 (316)
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Prenylated Diphenyl Ethers from the Marine Algal-Derived Endophytic Fungus Aspergillus tennesseensis
Molecules, 2018 Considerable attention has been paid to marine derived endophytic fungi, owing to their capacity to produce novel secondary metabolites with potent bioactivities. In this study, two new compounds with a prenylated diphenyl ether structure—diorcinol
Zhao-Xia Li +7 more
doaj +1 more source
Brake wear (nano)particle characterization and toxicity on airway epithelial cells in vitro [PDF]
Environmental Science: Nano 5, 1036 - 1044 (2018), 2018 Particulate air pollution results from different sources, among which those related to road traffic have a significant impact on human health. Combustion-derived particles emitted by thermal engines have been incriminated and are now better controlled.
arxiv +1 more source
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola
Molecules, 2019 As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Laurence K. Jennings +6 more
doaj +1 more source
Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens
Molecules, 2020 A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (−)-loliolide (7), and (+)-epiloliolide (8), was ...
Mioko Kawaguchi +6 more
doaj +1 more source
The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles
International Journal of Nanomedicine, 2012 Many types of nanoparticles (NPs) are tested for use in medical products, particularly in imaging and gene and drug delivery. For these applications, cellular uptake is usually a prerequisite and is governed in addition to size by surface characteristics
E. Fröhlich
semanticscholar +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Cytotoxicity of Heated Chrysotile [PDF]
Environmental Health Perspectives, 1974 Cytotoxicity and hemolysis were studied in chrysotile and quartz. The biological activity of the surface seemed to be different between chrysotile and quartz. Quartz lost its cytotoxicity on heating over about 500 degrees C. However chrysotile showed remarkable toxicity and induced hemolysis on heating between 650 and 800 degrees C, compared with the ...
openaire +3 more sources
Calcium Signaling and Cytotoxicity [PDF]
Environmental Health Perspectives, 1999 The divalent calcium cation Ca(2+) is used as a major signaling molecule during cell signal transduction to regulate energy output, cellular metabolism, and phenotype. The basis to the signaling role of Ca(2+) is an intricate network of cellular channels and transporters that allow a low resting concentration of Ca(2+) in the cytosol of the cell ([Ca(2+
George E.N. Kass, Sten Orrenius
openaire +3 more sources