Results 71 to 80 of about 1,197,953 (344)

The biogenic amines putrescine and cadaverine show in vitro cytotoxicity at concentrations that can be found in foods

Scientific Reports, 2019
Putrescine and cadaverine are among the most common biogenic amines (BA) in foods, but it is advisable that their accumulation be avoided. Present knowledge about their toxicity is, however, limited; further research is needed if qualitative and ...
B. del Rio, B. Redruello, D. Linares, V. Ladero, P. Ruas-Madiedo, María Fernández, M. Martín, M. Álvarez   +7 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

In vitro antiproliferative potential of Cassia angustifolia extracts on HepG2 cells to combat liver cancer

International Journal of Applied and Experimental Biology
Liver cancer is a terrifying disease with limited treatment options and is responsible for global health and economic burden. Most anticancer options have severe adverse effects, including non-specific modes of action that aggravate the challenges of ...
Aasia Kalsoom, Awais Altaf, Muhammad Idrees Jilani, Huma Sattar, Tahir Maqbool, Tahir Muhammad   +5 more
doaj   +1 more source

The Sesquiterpene Lactone Cynaropicrin Manifests Strong Cytotoxicity in Glioblastoma Cells U-87 MG by Induction of Oxidative Stress [PDF]

, 2022
Rossella Rotondo, Maria Antonietta Oliva, Antonietta Arcella   +2 more
openalex   +1 more source

Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity

Cell Death and Disease, 2017
Interferon gamma (IFNγ) is a key moderator of cell-mediated immunity with diverse, mainly pro-inflammatory actions on immunocytes and target tissue. Recent studies have shown it may enhance anti-tumor and antiviral effects of CD8 T cells.
P. Bhat, G. Leggatt, N. Waterhouse, I. Frazer   +3 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

In Vitro Cytotoxicity and Cell Viability Assays: Principles, Advantages, and Disadvantages

Genotoxicity - A Predictable Risk to Our Actual World, 2017
Cytotoxicity is one of the most important indicators for biological evaluation in vitro studies. In vitro, chemicals such as drugs and pesticides have different cytotoxicity mechanisms such as destruction of cell membranes, prevention of protein ...
Özlem Sultan Aslantürk
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Assessment of Antimicrobial Activity Against Candida albicans, Streptococcus mutans, Enterococcus faecalis and Staphylococcus aureus and Cytotoxic Effect of the Mouthwash Prepared Using Persea americana and Clove - An In Vitro Study

Indian Journal of Dental Research
Context: A natural mouthwash with minimal side effects is essential for obviating the disadvantages of chemically based mouthwashes. Research has been carried out worldwide using herbal extracts from leaves, stems, seeds, fruits, etc., for various dental
S Dharini, Gheena Sukumaran, Pratibha Ramani, Rajeshkumar Shanmugam, Karthikeyan Ramalingam   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source