Results 81 to 90 of about 1,197,953 (344)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Uncovering Fibrocapsa japonica (Raphidophyceae) in South America: First Taxonomic and Toxicological Insights from Argentinean Coastal Waters

Toxins
Fibrocapsa japonica (Raphidophyceae) is a cosmopolitan species frequently associated with harmful algal blooms (HABs) and fish mortality events, representing a potential threat to aquaculture and coastal ecosystems.
Delfina Aguiar Juárez, Inés Sunesen, Ana Flores-Leñero, Luis Norambuena, Bernd Krock, Gonzalo Fuenzalida, Jorge I. Mardones   +6 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effects of chemical modifications on hemoglobin’s toxicity towards human cardiac myocytes

Frontiers in Molecular Biosciences
BackgroundHemoglobin-based oxygen carriers (HBOCs) also known as blood substitutes were developed by chemical or genetic alterations of cell-free human or bovine Hbs to prolong the circulation time of Hb and to improve its ability to unload oxygen ...
Sirsendu Jana, Haley Garbus-Grant, Tigist Kassa, Abdu I. Alayash   +3 more
doaj   +1 more source

CD56 in the Immune System: More Than a Marker for Cytotoxicity?

Frontiers in Immunology, 2017
Over the past years, the phenotypic and functional boundaries distinguishing the main cell subsets of the immune system have become increasingly blurred. In this respect, CD56 (also known as neural cell adhesion molecule) is a very good example.
H. Van Acker, A. Capsomidis, E. Smits, V. V. Van Tendeloo   +3 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Unveiling the antimicrobial, biofilm inhibition, and photoprotective potential of Bupleurum falcatum L. for dermatological applications

EXCLI Journal : Experimental and Clinical Sciences
Bupleurum falcatum L. is known for its therapeutic properties, especially in treating fever, inflammation, and infectious diseases. However, its potential for dermatological applications remains mainly unexplored.
Mirjana Milinković Srećković, Jovana Petrović, Marija Ivanov, Uroš Gašić, Milena Milivojević, Danijela Stanisavljević Ninković, Dejan Stojkovic   +6 more
doaj   +1 more source

Design and Synthesis of Xanthone Analogues Conjugated with Aza‐aromatic Substituents as Promising G‐Quadruplex Stabilizing Ligands and their Selective Cancer Cell Cytotoxic Action [PDF]

, 2022
Soma Roy, Nirmal Chakraborty, Bappa Maiti, K. Muniyappa, Santanu Bhattacharya   +4 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

INVESTIGATION OF ANTHRAQUINONE CONTENTS, DNA CLEAVAGE, DNA BINDING, CYTOTOXIC AND ANTIOXIDANT ACTIVITIES OF XANTHORIA PARIETINA SAMPLES

Studia Universitatis Babes-Bolyai Chemia
In this study, Xanthoria parietina samples were collected from different regions of Türkiye like Yozgat (Xp3), Izmit (Xp14), and Kütahya (Xp20). Anthracenedione, anthraquinone (parietin) contents of the lichens were determined quantitatively by GC-MS ...
Nilgün GÜLER, Emine KILIÇKAYA SELVİ
doaj   +1 more source