Management of children and adolescents with Wilson Disease and neurological worsening following D–Penicillamine therapy: A single centre experience [PDF]
Annals of Indian Academy of Neurology, 2022 Background: Most centers in developing countries prefer chelation therapy with D-penicillamine for the management of Wilson's disease (WD) because of its easy availability and affordability. Neurological worsening following treatment with D-penicillamine
Madhan Kumar +5 more
doaj +3 more sources
D-Penicillamine: The State of the Art in Humans and in Dogs from a Pharmacological and Regulatory Perspective [PDF]
Antibiotics, 2021 Chelant agents are the mainstay of treatment in copper-associated hepatitis in humans, where D-penicillamine is the chelant agent of first choice. In veterinary medicine, the use of D-penicillamine has increased with the recent recognition of copper ...
Michela Pugliese +6 more
doaj +2 more sources
Comparison of the Effectiveness and Safety of d-Penicillamine and Zinc Salt Treatment for Symptomatic Wilson Disease: A Systematic Review and Meta‐Analysis [PDF]
Frontiers in Pharmacology, 2022 Background: Pharmacological therapy is currently the main treatment method for patients with Wilson disease (WD). We aimed to evaluate the efficacy and safety of the common treatment regimens in these patients.Methods: We conducted a systemic review and ...
Shan Tang +10 more
doaj +2 more sources
D-Penicillamine Induced Degenerative Dermopathy in a Patient with Wilson Disease
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2018 D-penicillamine induced degenerative dermatosis include, among others, elastosis perforans serpiginosa, and pseudo- -pseudoxanthoma elasticum. Elastosis perforans serpiginosa is a rare perforating disease characterized by transepidermal elimination of ...
Rui Pedro Santos +2 more
doaj +3 more sources
D-penicillamine Induced Myasthenia Gravis in Wilson’s Disease: A Case Report [PDF]
Journal of Nepal Medical Association, 2022 Myasthenia gravis is a neuromuscular junction disorder characterised by fluctuating muscle weakness, improved by using anti-cholinesterase drugs. In addition to the autoimmune aetiology, various factors such as infections, surgery, and drugs are known ...
Lekhjung Thapa +7 more
doaj +2 more sources
Outcomes of Tiopronin and D-Penicillamine Therapy in Pediatric Cystinuria: A Clinical Comparison of Two Cases [PDF]
ReportsBackground and Clinical Significance: Cystinuria is the most common genetic cause of pediatric nephrolithiasis, characterized by impaired renal cystine reabsorption and resulting in increased urinary cystine excretion.
Brooke Schaefer +2 more
doaj +2 more sources
D-penicillamine in Wilson's disease; recognizing the transition from benefit to harm. [PDF]
eNeurologicalSci, 2021 Goh Y +8 more
europepmc +2 more sources
D-penicillamine induced degenerative dermopathy
Indian Journal of Dermatology, 2015 D-penicillamine interferes with elastin and collagen metabolism and produces several cutaneous and multi-systemic side-effects. We present two cases of Wilson′s disease who on long-term penicillamine therapy developed drug-induced degenerative dermopathy
Sujay Khandpur +4 more
doaj +2 more sources
D-Penicillamine prolongs survival and lessens copper-induced toxicity in Drosophila melanogaster. [PDF]
Toxicol Res (Camb), 2020 Abolaji AO +3 more
europepmc +3 more sources
Safety of penicillamine and trientine in the treatment of Wilson's disease: An analysis of the FDA Adverse Event Reporting System (FAERS) database. [PDF]
PLoS ONEBackgroundPenicillamine(D-Penicillamine) and trientine are first-line therapies for Wilson's Disease (WD), yet real-world data on their adverse events (AEs) remain scarce.
Wenlong Qian +12 more
doaj +2 more sources