Results 41 to 50 of about 15,206,096 (240)

Response to different therapeutic approaches in Wilson disease. A long-term follow up study

Annals of Hepatology, 2012
Background and aims. There are certain areas of uncertainty regarding the best therapeutic approach in patients diagnosed with Wilson Disease (WD). Our aim was to assess treatment response to different therapies in a cohort of WD patients followed in a ...
Beatriz Rodríguez, Juan Burguera, Marina Berenguer, M.D.   +2 more
doaj   +1 more source

Wilson's disease update: An Indian perspective

Annals of Indian Academy of Neurology, 2022
Wilson's disease (WD) is an autosomal recessive disorder due to ATP7B gene mutation, resulting in defective copper metabolism, with liver and brain being primarily affected.
Kalyan Bhattacharya, Bindu Thankappan
doaj   +1 more source

Lead(II) binding to the chelating agent D-penicillamine in aqueous solution. [PDF]

Inorg Chem, 2014
A spectroscopic investigation of the complexes formed between the Pb(II) ion and d-penicillamine (H2Pen), a chelating agent used in the treatment of lead poisoning, was carried out on two sets of alkaline aqueous solutions with CPb(II) ≈ 10 and 100 mM ...
Sisombath NS, Jalilehvand F, Schell AC, Wu Q.   +3 more
europepmc   +2 more sources

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source

Novel 3D‐Printed Biophotonic Scaffold Displaying Luminescence under Near‐Infrared Light for Photopharmacological Activation and Biological Signaling Compound Release

Advanced Healthcare Materials, EarlyView.
Despite significant efforts in developing novel biomaterials to regenerate tissue, only a few of them have successfully reached clinical use. It has become clear that the next generation of biomaterials must be multifunctional. Smart biomaterials can respond to environmental or external stimuli, interact in a spatial‐temporal manner, and trigger ...
Sonya Ghanavati, Ekin Opar, Virginia Alessandra Gobbo, Carlo Matera, Fabio Riefolo, Rossella Castagna, Julien Colombelli, Andrew Draganski, Joshua Baggott, Mika Lastusaari, Pau Gorostiza, Laeticia Petit, Jonathan Massera   +12 more
wiley   +1 more source

Resistance of Oil‐Infused PDMS with Different Macroporosities Against Bacterial Attachment

Advanced Materials Interfaces, EarlyView.
In this study, a series of environmentally benign, nonfluorinated liquid paraffin‐infused porous PDMS networks with varying porosities is created. By introducing different homogenous and heterogenous bulk structures and varying interfacial roughness by sugar and salt templating, the role of porosity and oil availability on the resistance against ...
Regina Kopecz, Sabrina A. Böer, Zeynep Tiris, Axel Rosenhahn   +3 more
wiley   +1 more source

Cuprizone-induced Demyelination in Mouse Brain is not due to Depletion of Copper

ASN Neuro, 2022
The cuprizone (CPZ) model allows the study of the biochemical processes underlying nonautoimmune-mediated demyelination, remyelination, and chronic white matter disease progression.
Megan L. Morgan, Wulin Teo, Yda Hernandez, Craig Brideau, Karen Cummins, Hedwich F. Kuipers, Peter K. Stys   +6 more
doaj   +1 more source

A scoping review of disease‐modifying antirheumatic drug nonadherence in rheumatoid arthritis: Measurement, prevalence and implications for clinical practice

British Journal of Clinical Pharmacology, EarlyView.
Aims Adherence to disease‐modifying antirheumatic drugs (DMARDs) has been associated with improved treatment outcomes, but how adherence is reported ranges between studies. We therefore aimed to determine how nonadherence to DMARDs used to treat rheumatoid arthritis (RA) has been measured and to report the nonadherence rate with each measure identified.
Lauren Fraser, Nagham Ailabouni, Lisa Kalisch Ellett, Jiun Ming Tan, Anthea Freeman, Susanna M. Proudman, Emily Reeve, Michael D. Wiese   +7 more
wiley   +1 more source

Chiral Imprinting on Inorganic Nanoparticles for Enantioselective Surface Recognition

Small, EarlyView.
Chiral imprinting on titanium dioxide (TiO2) nanoparticles is achieved by introducing a chiral ligand during nucleation and growth. After ligand removal by ultraviolet (UV) irradiation, enantioselectivity is demonstrated via refunctionalization in a racemic mixture, where the surface preferentially binds the original enantiomer. These results show that
Susanna Tinello, Mélanie Emery, Markus Niederberger   +2 more
wiley   +1 more source

Metal‐Responsive Up‐Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
A stress‐responsive folding promotor was developed by conjugating metal‐binding ligands and a redox‐active disulfide. The oxidative strength of the bifunctional disulfide was enhanced by metal coordination, inhibiting protein misfolding and up‐regulating the oxidative folding capacity under metal stress.
Keita Mori, Tsubura Kuramochi, Motonori Matsusaki, Yuki Hashiguchi, Masaki Okumura, Tomohide Saio, Yoshiaki Furukawa, Kenta Arai, Takahiro Muraoka   +8 more
wiley   +2 more sources