Results 91 to 100 of about 544,097 (279)

Clinical and biochemical study of D-serine metabolism among schizophrenia patients

Neuropsychiatric Disease and Treatment, 2017
Hamdy N El-Tallawy,1 Tahia H Saleem,2 Abdallah MAA El-Ebidi,3 Mohammed H Hassan,4 Romany H Gabra,1 Wafaa MA Farghaly,1 Nagwa Abo El-Maali,5 Hoda S Sherkawy3 1Department of Neuropsychiatry, 2Department of Medical Biochemistry and Molecular Biology ...
El-Tallawy HN, Saleem TH, El-Ebidi AMA, Hassan MH, Gabra RH, Farghaly WMA, Abo El-Maali N, Sherkawy HS   +7 more
doaj  

d-Serine Degradation by Proteus mirabilis Contributes to Fitness during Single-Species and Polymicrobial Catheter-Associated Urinary Tract Infection

mSphere, 2019
Proteus mirabilis is a common cause of catheter-associated urinary tract infection (CAUTI) and secondary bacteremia, which are frequently polymicrobial.
Aimee L. Brauer, Ashley N. White, Brian S. Learman, Alexandra O. Johnson, Chelsie E. Armbruster   +4 more
doaj   +1 more source

Cell-to-Cell Communication in Learning and Memory: From Neuro- and Glio-Transmission to Information Exchange Mediated by Extracellular Vesicles [PDF]

, 2019
Most aspects of nervous system development and function rely on the continuous crosstalk between neurons and the variegated universe of non-neuronal cells surrounding them.
Di Liegro, Carlo Maria, Di Liegro, Italia, Schiera, Gabriella   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Global and local expression of chirality in serine on the Cu{110} surface [PDF]

, 2010
Establishing a molecular-level understanding of enantioselectivity and chiral resolution at the organic−inorganic interfaces is a key challenge in the field of heterogeneous catalysis.
Eralp, Tugce, Held, Georg Franz Konrad, Kalashnyk, Nataliya, Linderoth, Trolle R., Ning, Yanxiao, Shavorskiy, Andrey, Zheleva, Zhasmina V.   +6 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex. [PDF]

, 2012
N-methyl-D-aspartate receptors (NMDARs) subserve numerous neurophysiological and neuropathological processes in the cerebral cortex. Their activation requires the binding of glutamate and also of a coagonist.
Dulong, J., Fossat, P., Millan, M. J., Mothet, J., Oliet, S. H. R., POLLEGIONI, LOREDANO, Rivet, J., SACCHI, SILVIA, Shi, T., Sweedler, J. V., Turpin, F. R.   +10 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

D-serine: trick or treat?

Access Microbiology, 2019
D-serine is an amino acid that has become a focus in recent years due to its unique role in many biological processes. It is a host metabolite in humans with diverse roles in neurotransmission and signalling. Previous work in our group showed that D-serine can play a critical role in controlling expression of pathogenic virulence factors in bacteria ...
openaire   +1 more source