D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. [PDF]
PLoS ONE, 2016 N-methyl-D-aspartate (NMDA) receptors play critical roles in synaptic transmission and plasticity. Activation of NMDA receptors by synaptically released L-glutamate also requires occupancy of co-agonist binding sites in the tetrameric receptor by either ...
Alan C Foster +9 more
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Impaired D-Serine-Mediated cotransmission mediates cognitive dysfunction in epilepsy [PDF]
, 2013 The modulation of synaptic plasticity by NMDA receptor (NMDAR)-mediated processes is essential for many forms of learning and memory. Activation of NMDARs by glutamate requires the binding of a coagonist to a regulatory site of the receptor.
Beck, Heinz +9 more
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Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the NMDAR Glycine Co-Agonist Site [PDF]
, 2013 BACKGROUND: Stimulating the glycine(B) binding site on the N-methyl-D-aspartate receptor (NMDAR) has been proposed as a novel mechanism for modulating behavioral effects of ethanol (EtOH) that are mediated via the NMDAR, including acute intoxication ...
Atkinson +60 more
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Heterogeneity of D-Serine Distribution in the Human Central Nervous System
ASN Neuro, 2017 D-serine is an endogenous ligand for N -methyl-D-aspartate glutamate receptors. Accumulating evidence including genetic associations of D-serine metabolism with neurological or psychiatric diseases suggest that D-serine is crucial in human ...
Masataka Suzuki +5 more
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Amperometric Self-Referencing Ceramic Based Microelectrode Arrays for D-Serine Detection
Biosensors, 2018 D-serine is the major D-amino acid in the mammalian central nervous system. As the dominant co-agonist of the endogenous synaptic NMDA receptor, D-serine plays a role in synaptic plasticity, learning, and memory.
Diana Campos-Beltrán +3 more
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Synthesis and biological evaluation of novel PDMP analogues [PDF]
, 2006 A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from D-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward ...
Boldin-Adamsky, Swetlana +5 more
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Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase
Frontiers in Molecular Biosciences, 2021 In the central nervous system, the flavoprotein D-amino acid oxidase is responsible for catabolizing D-serine, the main endogenous coagonist of N-methyl-D-aspartate receptor.
Silvia Sacchi +3 more
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The FASEB Journal, 2010 ABSTRACT d ‐Serine is thought to be a glia‐derived transmitter that activates N ‐methyl d ‐aspartate receptors (NMDARs) in the brain.
Dina, Rosenberg +5 more
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Astroglial versus Neuronal D-Serine: Fact Checking [PDF]
Trends in Neurosciences, 2017 The activation of NMDA receptors (NMDARs) is conditioned by the binding of a co-agonist to a dedicated receptor binding site. It is now largely accepted that D-serine plays this role at many central synapses in the hippocampus, amygdala, hypothalamus, nucleus accumbens, and in prefrontal, visual, and somatosensory cortices.
Papouin, Thomas +3 more
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D-Serine as a putative glial neurotransmitter [PDF]
Neuron Glia Biology, 2004 Abundant recent evidence favors a neurotransmitter/neuromodulator role for D-serine. D-serine is synthesized from L-serine by serine racemase in astrocytic glia that ensheath synapses, especially in regions of the brain that are enriched in NMDA-glutamate receptors.
Asif K, Mustafa +2 more
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