Results 111 to 120 of about 10,757,883 (334)

STIC2 selectively binds ribosome-nascent chain complexes in the cotranslational sorting of Arabidopsis thylakoid proteins

The EMBO Journal
Chloroplast-encoded multi-span thylakoid membrane proteins are crucial for photosynthetic complexes, yet the coordination of their biogenesis remains poorly understood.
Dominique S Stolle, Lena Osterhoff, Paul Treimer, Jan Lambertz, Marie Karstens, Jakob-Maximilian Keller, Ines Gerlach, Annika Bischoff, Beatrix Dünschede, Anja Rödiger, Christian Herrmann, Sacha Baginsky, Eckhard Hofmann, Reimo Zoschke, Ute Armbruster, Marc M Nowaczyk, Danja Schünemann   +16 more
doaj   +1 more source

Expression and subcellular localization of cyclin D1 protein in epithelial ovarian tumour cells [PDF]

, 1999
The expression of cyclin D1 protein in tumour sections from 81 patients with epithelial ovarian cancer was analysed using immunohistochemistry. The tumours that overexpressed cyclin D1 in more than 10% of neoplastic cells were considered positive.
J Parkes, K K Dhar, Fryer, A A, Dhar, K K, P R Hoban, Redman, C W E, Musgrove, C, Parkes, J, R E J Howells, Howells, R E J, Hand, P, Strange, R C, Hoban, P R, K Branigan, C W E Redman, P Hand, R C Strange, A A Fryer, Branigan, K, C Musgrove   +19 more
core   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Varying light regimes in naturally growing Jatropha curcus: pigment, proline and photosynthetic performance [PDF]

Journal of Stress Physiology & Biochemistry, 2010
Light stress is a major abiotic stress which adversely affects productivity of the plants. Tolerance to abiotic stresses is very complex, due to the intricate of interactions between stress factors and various molecular, biochemical and physiological ...
Wadhwa R., N. Kumari, V. Sharma
doaj  

RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis

Respiratory Research, 2006
Background Idiopathic Pulmonary Fibrosis (IPF) is a debilitating disease characterized by exaggerated extracellular matrix deposition and aggressive lung structural remodeling.
Hoban PR, Cottrell E, Watts KL, Spiteri MA   +3 more
doaj   +1 more source

Specific degradation of photosystem II D1 protein by a protease (Alr3815) in heterocysts of the cyanobacterium Anabaena sp PCC7120

, 2011
Some filamentous cyanobacteria form heterocysts under conditions lacking combined nitrogen for nitrogen fixation. Photosystem II is removed from heterocyst during the process of cell differentiation.
Zhao, JD, Peking Univ, Coll Life Sci, State Key Lab Prot & Plant Genet Engn, Beijing 100871, Peoples R China, Zhao JinDong, Yang GuoHua, Hu Bin, jzhao@pku.edu.cn   +4 more
core  

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma

Journal of Otolaryngology - Head and Neck Surgery, 2018
Background Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has an improved outcome and may allow for treatment de-escalation.
Michaela Plath, Martina A. Broglie, Diana Förbs, Sandro J. Stoeckli, Wolfram Jochum   +4 more
doaj   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source