Results 131 to 140 of about 258,771 (261)

Protein kinase D1 (PKD) [PDF]

open access: yesScience-Business eXchange, 2008
openaire   +1 more source

Real‐Time Multicolor Fluorescence Microscopy via Cross‐Channel Acquisition and Deep‐Learning‐Based Inference

open access: yesAdvanced Intelligent Discovery, EarlyView.
Sequential multicolor fluorescence imaging in dynamic microsystems is constrained by acquisition speed and excitation dose. This study introduces a real‐time framework to reconstruct spectrally separated channels from reduced cross‐channel acquisitions (frames containing mixed spectral contributions).
Juan J. Huaroto   +3 more
wiley   +1 more source

Robust Representation Learning for Clean Feature Discovery in Incomplete Multi‐View Clustering

open access: yesAdvanced Intelligent Systems, EarlyView.
Robust feature discovery in incomplete multi‐view clustering is achieved by coupling RPCA‐based clean representation recovery with neural‐network‐assisted graph learning. The resulting RIMVC framework constructs cleaner and more discriminative graph‐structured representations from incomplete and noisy multi‐view data, improving clustering robustness ...
Ping Hu   +4 more
wiley   +1 more source

Accounting for animal health in efficiency analysis: An application to Swedish dairy farms

open access: yesAmerican Journal of Agricultural Economics, EarlyView.
Abstract Poor animal health is a central concern in modern livestock production. Despite the necessity to incorporate animal health in efficiency analysis, the theoretical and empirical developments are limited on this subject. This article appropriately characterizes the axiomatic properties of animal health within a production framework.
Frederic Ang   +3 more
wiley   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang   +6 more
wiley   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

open access: yesAnnals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl   +10 more
wiley   +1 more source

Biosynthesis of the Fully Saturated C16 Homosesquiterpene Descartane Through Deprotonation With Cyclopropanation

open access: yesAngewandte Chemie International Edition, EarlyView.
A non‐canonical C16 sesquiterpene synthase from Morganella morganii produces the unusual scaffold descartane. Its cyclisation mechanism was rationalised by isotopic labelling experiments and DFT calculations. Site‐directed mutagenesis altered enzyme function, resulting in alternative products, including voltairene, which requires a different ...
Kexin Yang   +4 more
wiley   +1 more source

Morphological and morphometric aspects of the equine aortic valve: New insights for comparative studies in mammals

open access: yesThe Anatomical Record, EarlyView.
Abstract New data on the equine aortic valve obtained using advanced techniques is especially important given the greater availability of animal models for translational research. Here we characterized the morphological and morphometric aspects of the equine aortic valve from 60 healthy hearts collected at equine abattoirs.
Vitor Pires Pereira   +3 more
wiley   +1 more source

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