Results 31 to 40 of about 6,788,938 (298)

SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy

Cell Division, 2007
Cyclin D1 is an allosteric regulator for cyclin-dependent kinases 4 and 6 (CDK4/6). The cyclin D/CDK4 kinase promotes G1/S transition through the posttranslational modification and the subsequent inactivation of the retinoblastoma (Rb) protein and ...
Lin Douglas I, Barbash Olena, Diehl J Alan   +2 more
doaj   +1 more source

Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells

BMC Complementary and Alternative Medicine, 2017
Background Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail.
Su Bin Park, Gwang Hun Park, Hun Min Song, Ho-Jun Son, Yurry Um, Hyun-Seok Kim, Jin Boo Jeong   +6 more
doaj   +1 more source

Regulation of Cardiac Stress Signaling by Protein Kinase D1 [PDF]

Molecular and Cellular Biology, 2006
In response to pathological stresses such as hypertension or myocardial infarction, the heart undergoes a remodeling process that is associated with myocyte hypertrophy, myocyte death, and fibrosis. Histone deacetylase 5 (HDAC5) is a transcriptional repressor of cardiac remodeling that is subject to phosphorylation-dependent neutralization in response ...
Brooke C, Harrison, Mi-Sung, Kim, Eva, van Rooij, Craig F, Plato, Philip J, Papst, Rick B, Vega, John A, McAnally, James A, Richardson, Rhonda, Bassel-Duby, Eric N, Olson, Timothy A, McKinsey   +10 more
openaire   +2 more sources

ATP and light regulate D1 protein modification and degradation Role of D1* in photoinhibition

FEBS Letters, 1992
We have recently shown that during in vivo photoinhibition the D1 protein is degraded via a modified form, designated D1*. Depending on light conditions, the amount of D1* varies in leaves between 0 and 50% of total D1 content. By isolating thylakoids from leaves acclimated to different light levels, and performing photoinhibition experiments on these ...
Aro, Eva-Mari, Kettunen, Reetta, Tyystjärvi, Esa   +2 more
openaire   +2 more sources

Oligomycin induced the proteasomal degradation of cyclin D1 protein [PDF]

The Journal of Antibiotics, 2009
We searched for compounds that affect the cyclin D1/retinoblastoma protein pathway from the in-house natural product library using a recombinant adenovirus with the Cre/loxP-regulated cyclin D1 overexpression system, and we found that oligomycin inhibited cell growth more effectively in cyclin D1-overexpressing SW480 cells than in control SW480 cells ...
Mai, Kanai, Satoru, Iba, Ryoko, Okada, Etsu, Tashiro, Masaya, Imoto   +4 more
openaire   +2 more sources

Cyclin D1 Protein Tissue Detection in Laryngeal Cancer

ORL, 2005
Cyclin D1 (CCND1) is a set of periodic regulatory proteins that is believed to govern cell cycle transit from G1 into S phase. Overexpression of CCND1 leads to abnormal cellular proliferation which underlies processes of tumorigenesis; CCND1 can thus function as a cooperative oncogene in cell transformation.
Segas, JV, Lazaris, AC, Nikolopoulos, TP, Kavantzas, NG, Lendari, IE, Tzagkaroulakis, AM, Patsouris, ES, Ferekidis, EA   +7 more
openaire   +3 more sources

An Atypical psbA Gene Encodes a Sentinel D1 Protein to Form a Physiologically Relevant Inactive Photosystem II Complex in Cyanobacteria*

Journal of Biological Chemistry, 2014
Background: Unicellular cyanobacteria separate photosynthesis and nitrogen fixation using a day-night cycle. Results: Cyanothece 51142 expresses a D1 protein exclusively in the dark period that assembles nonfunctional photosystem II.
Kimberly M. Wegener, Aparna Nagarajan, H. Pakrasi   +2 more
semanticscholar   +1 more source

The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium

Respiratory Research, 2018
Background Dopamine receptors comprise two subgroups, Gs protein-coupled “D1-like” receptors (D1, D5) and Gi-coupled “D2-like” receptors (D2, D3, D4). In airways, both dopamine D1 and D2 receptors are expressed on airway smooth muscle and regulate airway
Nao Matsuyama, Sumire Shibata, Atsuko Matoba, Tada-aki Kudo, Jennifer Danielsson, Atsushi Kohjitani, Eiji Masaki, Charles W. Emala, Kentaro Mizuta   +8 more
doaj   +1 more source

Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma

World Journal of Surgical Oncology, 2012
Background Cyclin D1 gene regulates cell cycle and plays an important role in the tumorigenesis of human cancers. The association between cyclin D1, clinicopathologic parameters and prognosis in oral cavity squamous cell carcinoma (OSCC) is inconclusive.
Huang Shiang-Fu, Cheng Sou-De, Chuang Wen-Yu, Chen I-How, Liao Chun-Ta, Wang Hung-Ming, Hsieh Ling-Ling   +6 more
doaj   +1 more source

Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells

BMC Complementary and Alternative Medicine, 2019
Background Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. thea has been reported, but the potential mechanism for the anti-cancer property of S. thea
Ha Na Kim, Gwang Hun Park, Su Bin Park, Jeong Dong Kim, Hyun Ji Eo, Ho-Jun Son, Jeong Ho Song, Jin Boo Jeong   +7 more
doaj   +1 more source