Results 41 to 50 of about 6,788,938 (298)

Mechanism of Persistent Protein Kinase D1 Translocation and Activation [PDF]

Developmental Cell, 2003
The specificity of many signal transduction pathways relies on the spatiotemporal features of each signaling step. G protein-coupled receptor-mediated activation of protein kinases leads to diverse cellular effects. Upon receptor activation, PKD1 and several C-type protein kinases (PKCs), translocate to the plasma membrane and become catalytically ...
Oancea, Elena, Bezzerides, Vassilios J., Greka, Anna, Clapham, David E.   +3 more
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CCND1 copy number increase and cyclin D1 expression in acral melanoma: a comparative study of fluorescence in situ hybridization and immunohistochemistry in a Chinese cohort

Diagnostic Pathology, 2021
Background CCND1 copy number increase is characteristic of acral melanoma and is useful in distinguishing benign and malignant acral melanocytic lesions. Increase of the gene copy number may result in protein overexpression.
Jianying Liu, Wenjuan Yu, Fei Gao, Shuangshuang Qi, Juan Du, Xiaolong Ma, Yan Zhang, Jie Zheng, Jing Su   +8 more
doaj   +1 more source

Protein Kinase D1: A New Component in TLR9 Signaling [PDF]

The Journal of Immunology, 2008
AbstractProtein kinase D1 (PKD1) is expressed ubiquitously and regulates diverse cellular processes such as oxidative stress, gene expression, cell survival, and vesicle trafficking. However, the presence and function of PKD1 in monocytic cells are currently unknown.
Jeoung-Eun, Park, Young-In, Kim, Ae-Kyung, Yi   +2 more
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Ethanol extracts from the branch of Taxillus yadoriki parasitic to Neolitsea sericea induces cyclin D1 proteasomal degradation through cyclin D1 nuclear export

BMC Complementary and Alternative Medicine, 2018
Background Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied.
Su Bin Park, Gwang Hun Park, Ha Na Kim, Hun Min Song, Ho-Jun Son, Ji Ae Park, Hyun-Seok Kim, Jin Boo Jeong   +7 more
doaj   +1 more source

Pancreatic oncogenic signaling cascades converge at Protein Kinase D1 [PDF]

Cell Cycle, 2015
Although over 95% of pancreatic ductal adenocarcinoma (PDA) harbor Kras mutations, the presence of an oncogenic allele of Kras alone is not sufficient to develop pancreatic cancer. Moreover, mutant Kras is not constitutively-active per se,1 and requires additional stimulation to initiate a feed forward loop for enhanced pathological level of activity.2
Geou-Yarh, Liou, Michael, Leitges, Peter, Storz   +2 more
openaire   +2 more sources

Dr. Autar Krishen Mattoo (1943-2024): an outstanding plant biologist with a focus on photosynthesis

Photosynthetica
We provide here the academic life of Dr. Autar Krishen Mattoo (1943-2024), including his role as a research leader at the United States Department of Agriculture and his outstanding contributions in photosynthesis, plant physiology and molecular biology ...
A.K. HANDA, M. EDELMAN, W.W. ADAMS III, G. GOVINDJEE   +3 more
doaj   +1 more source

Modulation of catalytic activity in multi-domain protein tyrosine phosphatases. [PDF]

PLoS ONE, 2011
Signaling mechanisms involving protein tyrosine phosphatases govern several cellular and developmental processes. These enzymes are regulated by several mechanisms which include variation in the catalytic turnover rate based on redox stimuli, subcellular
Lalima L Madan, S Veeranna, Khader Shameer, Chilamakuri C S Reddy, R Sowdhamini, B Gopal   +5 more
doaj   +1 more source

Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling [PDF]

Journal of Cell Science, 2009
Increases in reactive oxygen species (ROS) have been implicated in age-related diseases, including cancer. The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-κB signaling.
Catherine F, Cowell, Heike, Döppler, Irene K, Yan, Angelika, Hausser, Yoshio, Umezawa, Peter, Storz   +5 more
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Protein kinase D1 deficiency promotes differentiation in epidermal keratinocytes [PDF]

Journal of Dermatological Science, 2014
Protein kinase D (PKD or PKD1) is a serine/threonine protein kinase that has been shown to play a role in a variety of cellular processes; however, the function of PKD1 in the skin has not been fully investigated. The balance between proliferation and differentiation processes in the predominant cells of the epidermis, the keratinocytes, is essential ...
Vivek, Choudhary, Lawrence O, Olala, Ismail, Kaddour-Djebbar, Inas, Helwa, Wendy B, Bollag   +4 more
openaire   +2 more sources

HCF243 Encodes a Chloroplast-Localized Protein Involved in the D1 Protein Stability of the Arabidopsis Photosystem II Complex1[W][OA]

Plant Physiology, 2011
Numerous auxiliary nuclear factors have been identified to be involved in the dynamics of the photosystem II (PSII) complex. In this study, we characterized the high chlorophyll fluorescence243 (hcf243) mutant of Arabidopsis (Arabidopsis thaliana), which
Dongyuan Zhang, Gongke Zhou, Bingbing Liu, Y. Kong, N. Chen, Q. Qiu, H. Yin, Jiaxing An, Fang Zhang, Fan Chen   +9 more
semanticscholar   +1 more source