Results 51 to 60 of about 6,788,938 (298)

Upregulation of NPL4 promotes bladder cancer cell proliferation by inhibiting DXO destabilization of cyclin D1 mRNA

Cancer Cell International, 2019
Background NPL4 is an important cofactor of the valosin-containing protein (VCP)–NPL4–UFD1 complex. The VCP–NPL4–UFD1 has been considered as a ubiquitin proteasome system (UPS) regulator and response to protein degradation.
Bao-Sai Lu, Yue-Wei Yin, Yan-Ping Zhang, Ping-Ying Guo, Wei Li, Kai-Long Liu   +5 more
doaj   +1 more source

Effects of dietary lipid-to-carbohydrate ratio on growth and carbohydrate metabolism in juvenile cobia (Rachycentron canadum)

Animal Nutrition, 2020
This experiment was conducted to investigate the effects of dietary lipid-to-carbohydrate ratio on growth and carbohydrate metabolism in juvenile cobia (Rachycentron canadum). Six isonitrogenous diets were prepared to vary in lipid-to-carbohydrate ratio (
Hongxia Zhao, Junming Cao, Xiaoying Chen, Guoxia Wang, Junru Hu, Bing Chen   +5 more
doaj   +1 more source

Cyclin D1 protein expression in mantle cell lymphoma

Annals of Oncology, 1995
The t(11;14)(q13;q32) is a chromosomal abnormality usually associated with mantle cell (centrocytic) lymphomas, although it has occasionally been reported in other chronic lymphoproliferative disorders such as chronic lymphocytic leukemia, prolymphocytic leukemia, splenic lymphoma with villous lymphocytes, and multiple myeloma. This abnormality results
S, Alkan, B, Schnitzer, J L, Thompson, L C, Moscinski, C W, Ross   +4 more
openaire   +2 more sources

Requirement of protein kinase D1 for pathological cardiac remodeling [PDF]

Proceedings of the National Academy of Sciences, 2008
The adult heart responds to biomechanical stress and neurohormonal signaling by hypertrophic growth, accompanied by fibrosis, diminished pump function, and activation of a fetal gene program. Class II histone deacetylases (HDACs) suppress stress-dependent remodeling of the heart via their association with the MEF2 transcription factor, an ...
Jens, Fielitz, Mi-Sung, Kim, John M, Shelton, Xiaoxia, Qi, Joseph A, Hill, James A, Richardson, Rhonda, Bassel-Duby, Eric N, Olson   +7 more
openaire   +2 more sources

Over‐expression of cyclin D1 regulates Cdk4 protein synthesis [PDF]

Cell Proliferation, 2003
Abstract.  Increased Cdk4 expression occurs coincident with over‐expression of cyclin D1 in many human tumours and tumourigenic mouse models. Here, we investigate both in vivo and in vitro the mechanism by which Cdk4 expression is regulated in the context of cyclin D1 over‐expression.
M A, Parker, N G, Deane, E A, Thompson, R H, Whitehead, S K, Mithani, M K, Washington, P K, Datta, D A, Dixon, R D, Beauchamp   +8 more
openaire   +2 more sources

The promyelocytic leukemia (PML) protein suppresses cyclin D1 protein production by altering the nuclear cytoplasmic distribution of cyclin D1 mRNA [PDF]

Oncogene, 2000
The majority of the promyelocytic leukemia (PML) protein is present in nuclear bodies which are altered in several pathogenic conditions including acute promyelocytic leukemia. PML nuclear bodies are found in nearly all cells yet their function remains unknown.
H K, Lai, K L, Borden
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Retrotransposon-mediated DELLA transcriptional reprograming underlies semi-dominant dwarfism in foxtail millet

Crop Journal, 2019
Retrotransposons account for a large proportion of the genome and genomic variation, and play key roles in creating novel genes and diversifying the genome in many eukaryotic species. Although retrotransposons are abundant in plants, their roles had been
Meicheng Zhao, Hui Zhi, Xue Zhang, Guanqing Jia, Xianmin Diao   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Expression of p16 protein and cyclin d1 in periampullary carcinomas [PDF]

Turkish Journal of Pathology, 2011
The majority of the tumors in periampullary region are pancreatic and ampulla of Vater carcinomas. The aim of this study was to compare histopathological features of ampulla of Vater carcinomas with pancreatic ductal adenocarcinomas and to determine diagnostic and predictive values of p16 protein and cyclin D1 expression.Tissue samples from pancreatic ...
Tuncer, E., Şen Türk, Nilay, Arıci, Sema, Düzcan, S.E., Çallı Demirkan, Neşe   +4 more
openaire   +7 more sources