Results 11 to 20 of about 5,119,262 (363)
, 2012 Reactive oxygen species (ROS) are produced as a normal product of plant cellular metabolism. Various environmental stresses lead to excessive production of ROS causing progressive oxidative damage and ultimately cell death.
Pallavi Sharma +3 more
semanticscholar +1 more source
Nature Communications, 2019 The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and
Owen Addis Jones +4 more
doaj +1 more source
Cell Transplantation, 2018 Diabetic retinopathy (DR), one of the leading causes of vision loss worldwide, is characterized by neurovascular disorders. Emerging evidence has demonstrated retinal neurodegeneration in the early pathogenesis of DR, and no treatment has been developed ...
Liyuan Rong +9 more
doaj +1 more source
eLife, 2016 A spring-loaded mechanism can explain the activation process for a protein that has a crucial role in maintaining the genomic integrity of immature eggs ...
Ivano Amelio, Gerry Melino
openaire +3 more sources
Nature Communications, 2016 Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DNA ...
Gabrielle J. Grundy +7 more
doaj +1 more source
BioTechniques, 2014 Here we describe the adaptation of laser scanning cytometry (LSC) to measure micronuclei (MN) automatically in lymphocytes. MN frequencies were determined in irradiated human lymphocytes using the cytokinesis-block technique, and the results from LSC ...
Maxime François +3 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Ruixue Huang, P. Zhou
semanticscholar +1 more source
Cell Transplantation, 2017 Retinal regeneration and self-repair, whether in response to injury or degenerative disease, are severely impeded by glial scar formation by Müller cells (specialized retinal macroglia). We have previously demonstrated that the activation of Müller cells
Jing Xie +5 more
doaj +1 more source
International Journal of Cardiology: Heart & Vasculature, 2018 Background: It remains to be clarified whether liver stiffness is a direct risk factor for heart failure (HF) or whether its association with HF is mediated by vascular damage.
Yoichi Iwasaki +8 more
doaj +1 more source
Measurements of elastic properties and their dependencies within a damage mechanics workflow
Rock Mechanics Bulletin, 2023 Experimental rock mechanics testing provides a controlled and effective method for measuring physical properties, their dependencies, and their evolution due to the addition of localized microcracks.
Erik P. Knippel +3 more
doaj +1 more source