Results 11 to 20 of about 2,459,996 (268)
Cell Transplantation, 2018 Diabetic retinopathy (DR), one of the leading causes of vision loss worldwide, is characterized by neurovascular disorders. Emerging evidence has demonstrated retinal neurodegeneration in the early pathogenesis of DR, and no treatment has been developed ...
Liyuan Rong +9 more
doaj +1 more source
BioTechniques, 2014 Here we describe the adaptation of laser scanning cytometry (LSC) to measure micronuclei (MN) automatically in lymphocytes. MN frequencies were determined in irradiated human lymphocytes using the cytokinesis-block technique, and the results from LSC ...
Maxime François +3 more
doaj +1 more source
eLife, 2016 A spring-loaded mechanism can explain the activation process for a protein that has a crucial role in maintaining the genomic integrity of immature eggs ...
Ivano Amelio, Gerry Melino
openaire +3 more sources
Nature Communications, 2016 Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DNA ...
Gabrielle J. Grundy +7 more
doaj +1 more source
Cell Transplantation, 2017 Retinal regeneration and self-repair, whether in response to injury or degenerative disease, are severely impeded by glial scar formation by Müller cells (specialized retinal macroglia). We have previously demonstrated that the activation of Müller cells
Jing Xie +5 more
doaj +1 more source
International Journal of Cardiology: Heart & Vasculature, 2018 Background: It remains to be clarified whether liver stiffness is a direct risk factor for heart failure (HF) or whether its association with HF is mediated by vascular damage.
Yoichi Iwasaki +8 more
doaj +1 more source
Measurements of elastic properties and their dependencies within a damage mechanics workflow
Rock Mechanics Bulletin, 2023 Experimental rock mechanics testing provides a controlled and effective method for measuring physical properties, their dependencies, and their evolution due to the addition of localized microcracks.
Erik P. Knippel +3 more
doaj +1 more source
Scientific Reports, 2021 In response to UV irradiation, translesion DNA synthesis (TLS) utilizes specialized DNA polymerases to bypass replication-blocking lesions. In a well-established polymerase switch model, Polη is thought to be a preferred TLS polymerase to insert correct ...
Tonghui Bi +3 more
doaj +1 more source
Formation of an Explosively Formed Penetrator Warhead Using a Step-Shaped Charge
Shock and Vibration, 2022 In this study, the formation mechanism of an explosively formed penetrator (EFP) with tail fins was analyzed. Through static denotation and dynamic flight tests, the feasibility of using a step-shaped liner during the formation of an EFP with tail fins ...
Weizhan Wang +5 more
doaj +1 more source
Lysine Crotonylation: An Emerging Player in DNA Damage Response
Biomolecules, 2022 The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated ...
Yuqin Zhao +8 more
doaj +1 more source