Results 21 to 30 of about 5,119,262 (363)
Scientific Reports, 2021 In response to UV irradiation, translesion DNA synthesis (TLS) utilizes specialized DNA polymerases to bypass replication-blocking lesions. In a well-established polymerase switch model, Polη is thought to be a preferred TLS polymerase to insert correct ...
Tonghui Bi +3 more
doaj +1 more source
Lysine Crotonylation: An Emerging Player in DNA Damage Response
Biomolecules, 2022 The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated ...
Yuqin Zhao +8 more
doaj +1 more source
Formation of an Explosively Formed Penetrator Warhead Using a Step-Shaped Charge
Shock and Vibration, 2022 In this study, the formation mechanism of an explosively formed penetrator (EFP) with tail fins was analyzed. Through static denotation and dynamic flight tests, the feasibility of using a step-shaped liner during the formation of an EFP with tail fins ...
Weizhan Wang +5 more
doaj +1 more source
EMBO ReportsCyclosporin A (CsA) induces DNA double-strand breaks in LIG4 syndrome fibroblasts, specifically upon transit through S-phase. The basis underlying this has not been described.
Marisa Bedir +5 more
doaj +1 more source
Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus +6 more
wiley +1 more source
BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy
Cell Reports, 2014 BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180.
Peter M. Brownlee +4 more
doaj +1 more source
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling
Journal of Cell Biology, 2018 Superoxide dismutases (SODs) are universal enzymes of organisms that live in the presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen peroxide.
Ying Wang +3 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine +10 more
wiley +1 more source
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
Nature Communications, 2017 DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome
Fernando Gómez-Herreros +6 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan +5 more
wiley +1 more source