AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Mechanisms of damage prevention, signalling and repair impact disease tolerance. [PDF]
Proc Biol Sci, 2022 Prakash A, Monteith KM, Vale PF.
europepmc +1 more source
An Accidental Oil Spill Along the Belgian Coast: Results from a CV Study [PDF]
This paper offers an economic assessment of the loss of non-use values resulting from different oil spill scenarios along the Belgian Coast. Estimation results show that if no oil spill prevention policy action is undertaken, a significant welfare loss ...
Dirk Le Roy +2 more
core
Lifting the Burden of Addiction: Philanthropic Opportunities to Address Substance Use Disorders in the United States [PDF]
, 2015 Substance use disorders (SUDs), also known as substance abuse or addiction, affect an estimated 20 million or more adolescents and adults in the U.S. This guidance provides philanthropic funders with the tools & information to reduce immediate harm from ...
Cecily Wallman-Stokes +6 more
core
Diagnostic systems in DEMO: engineering design issues
, 2014 The diagnostic systems of DEMO that are mounted on or near the torus, whether intended for the monitoring and control functions of the engineering aspects or the physics behaviour of the machine, will have to be designed to suit the hostile nuclear ...
Todd, T N
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Preventive Metabolic Medicine in Primary Care
Journal of the Pakistan Medical AssociationThe responsibility, and right, of promoting metabolic health, and preventing metabolic disease, is that of the primary care physician. This communication lists the facets of metabolic care in a simple (Seven Rs) manner, connecting them with the various ...
Tint Swe Latt +3 more
doaj +1 more source
Rights and Duties of Governments to Prevent and Compensate Pollution of the Sea Resulting from the Transportation of Oil: A Study of International Declarations, Conventions and Awards [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒Umūmī, 2015 The damage to the sea environment is often irreversible, therefore, accordingto relevant declarations and conventions, prevention is considered as anobligation in order to conserve the environment.
Jafar Nory Yoshanloey +1 more
doaj
Exploring the learning needs of clinicians in Belgium and Sweden regarding prone positioning and skin damage prevention: A qualitative study. [PDF]
Nurse Educ Today, 2023 Fourie A +6 more
europepmc +1 more source
Understanding and preventing mitochondrial oxidative damage [PDF]
Biochemical Society Transactions, 2016 Mitochondrial oxidative damage has long been known to contribute to damage in conditions such as ischaemia–reperfusion (IR) injury in heart attack. Over the past years, we have developed a series of mitochondria-targeted compounds designed to ameliorate or determine how this damage occurs.
openaire +2 more sources