Results 81 to 90 of about 1,342,747 (314)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Cerebral Palsy - A Comprehensive Analysis of the Causes
Journal of Education, Health and SportIntroduction and Purpose: Cerebral palsy (CP) is a complex motor and postural disorder resulting from damage to the developing brain. The causes of CP are diverse and can occur at various stages of a child’s life— prenatal, perinatal, and ...
Joanna Olszak +9 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Periodontitis and the Elderly: An Overview of the Disease and its Impact on an Aging Population [PDF]
, 2019 Periodontitis affects millions of Americans each year, and is especially prevalent among the elderly. Since periodontitis is a chronic, progressive condition, uninterrupted disease progression leads to irreversible oral damage; therefore, periodontitis ...
Weissenfluh, Nicole Grace
core +1 more source
Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models [PDF]
, 2015 Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments.
Azevedo, Vasco +7 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Prevention of Hydrogen Damage Using MoS2 Coating on Iron Surface
Nanomaterials, 2019 The prevention of hydrogen penetration into steels can effectively protect steels from hydrogen damage. In this study, we investigated the effect of a monolayer MoS2 coating on hydrogen prevention using first-principles calculations.
Xiaolong Li +6 more
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Fatigue damage mechanism and failure prevention in fiberglass reinforced plastic
Materials Research, 2005 Damaging of composite laminates was monitored during fatigue tests, revealing the formation and propagation stages for compressive, tensile, or alternate cyclic loading.
Raimundo Carlos Silverio Freire Jr. +1 more
doaj +1 more source
Editorial: Beyond ultraviolet B radiation: exploring the impact of UVA on skin, reappraisal of UVA phototherapy, and advances in UVA-damage prevention. [PDF]
Front Med (Lausanne), 2023 Calzavara-Pinton P, Tonon F.
europepmc +1 more source