Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity [PDF]
, 2003 Although the accumulation of the neurotoxic peptide {beta} amyloid ({beta}A) in the CNS is a hallmark of Alzheimer's disease, the mechanism of {beta}A neurotoxicity remains controversial.
Abramov, A.Y. +2 more
core +1 more source
Advanced Biomedical Research, 2017 Background: Cerebral vasospasm is a prolonged, occasionally severe, but reversible narrowing of the cerebral arteries that begins 3 to 5 days after the hemorrhage becomes maximal at 14 days.
Masih Sabouri +4 more
doaj +1 more source
Conformational Studies of Ortho- and Meto-Isomers and Methyl, Dimethyl, and Chloro Ortho-Substituted Analogues of Dantrolene Using Ab Initio SCF-MO Procedures [PDF]
, 1995 The conformation of the nitro group of nitroaromatic compounds relative to the aromatic ringsystem is suggested to affect their metabolic activation and mutagenicity. We have recently showed the nitrophenylfuran skeletal muscle relaxant, dantrolene, tobe
Climer, Amber D. +5 more
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In vivo Ca2+ dynamics induced by Ca2+ injection in individual rat skeletal muscle fibers [PDF]
, 2017 Citation: Wakizaka, M., Eshima, H., Tanaka, Y., Shirakawa, H., Poole, D. C., & Kano, Y. (2017). In vivo Ca2+ dynamics induced by Ca2+ injection in individual rat skeletal muscle fibers. Physiological Reports, 5(5), 10.
Eshima, H. +5 more
core +1 more source
Mutism and rigidity due to antipsychotic‐induced catatonia improved by hemodialysis: A case report
Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 1, March 2025.We present a case of antipsychotic‐induced catatonia (AIC) due to intramuscular injection of haloperidol that was promptly improved by hemodialysis. This report suggests the potential role of hemodialysis in improving AIC. Abstract Background Catatonia is a psychomotor syndrome linked to various medical conditions.
Rintaro Fujii +4 more
wiley +1 more source
Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness [PDF]
, 2019 Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of the First Gulf War, and includes neurological symptoms characterized by depression and memory deficits.
Blair, Robert +3 more
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Management of serotonin syndrome (toxicity)
British Journal of Clinical Pharmacology, Volume 91, Issue 3, Page 654-661, March 2025.Serotonin syndrome (toxicity), resulting from an excessive accumulation of serotonin in the central nervous system, it can occur due to various factors such as the initiation of medication, overdose or drug interactions. Diagnosing serotonin toxicity presents challenges as there are no definitive criteria.
Angela L. Chiew, Geoffrey K. Isbister
wiley +1 more source
Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication [PDF]
, 2014 Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations. Exposure to POX produces high mortality.
Blair, Robert E. +4 more
core +2 more sources
Biological Function and Mechanism of NAT10 in Cancer
Cancer Innovation, Volume 4, Issue 1, February 2025.N‐acetyltransferase 10 (NAT10) is an acetyltransferase that mediates the acetylation of proteins and RNA. NAT10 positively affects the proliferation, metastasis, invasion, and drug resistance of various cancers through the regulation of cancer‐related proteins and genes.
Yufeng Han +6 more
wiley +1 more source