Results 101 to 110 of about 14,850 (297)

Alzheimer's disease pathology and the unfolded protein response : Prospective pathways and therapeutic targets [PDF]

, 2017
The authors would like to thank Alzheimer's Research UK (Grant refs: ARUK-PPG2014A-21 and ARUK-NSG2015-1 to BP and DK) who have provided support for relevant projects leading to this review.Peer ...
Koss, David J, Platt, Bettina
core   +1 more source

Emergent Treatment of Neuroleptic Malignant Syndrome Induced by Antipsychotic Monotherapy Using Dantrolene

Clinical Practice and Cases in Emergency Medicine, 2019
Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication resulting from neuroleptic drug therapy. Presentation of NMS can vary, and diagnosis relies primarily upon medical history and symptomatology. Due to the potential delay in
V. Ngo, Alfredo L. Guerrero, D. Lanum, M. Burgett-Moreno, G. Fenati, Steven Barr, M. Neeki   +6 more
semanticscholar   +1 more source

Impairment of Glucose Uptake Induced by Elevated Intracellular Ca²⁺ in Hippocampal Neurons of Malignant Hyperthermia-Susceptible Mice

Cells
Malignant hyperthermia (MH) is a genetic disorder triggered by depolarizing muscle relaxants or halogenated inhalational anesthetics in genetically predisposed individuals who have a chronic elevated intracellular Ca2+ concentration ([Ca2+]i) in their ...
Arkady Uryash, Alfredo Mijares, Jose A. Adams, Jose R. Lopez   +3 more
doaj   +1 more source

Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness [PDF]

, 2019
Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of the First Gulf War, and includes neurological symptoms characterized by depression and memory deficits.
Blair, Robert, Deshpande, Laxmikant, Phillips, Kristin, Santos, Edna   +3 more
core   +1 more source

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper [PDF]

, 2016
BACKGROUND AND OBJECTIVES: Treatment of spasticity poses a major challenge given the complex clinical presentation and variable efficacy and safety profiles of available drugs. We present a systematic review of the pharmacological treatment of spasticity
Comi, G, Gold, R, Hartung, HP, Montalban, X, Otero-Romero, S, Sastre-Garriga, J, Soelberg Sørensen, P, Thompson, AJ, Vermersch, P   +8 more
core   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Real‐Time Force Monitoring of Electrically Stimulated 3D‐Bioengineered Muscle Bioactuators Using Organic Sensors with Tunable Sensitivity

Advanced Intelligent Systems, Volume 7, Issue 10, October 2025.
The integration of sensing elements in bioengineered actuators is key to obtain real‐time information about their performance and further control/automation. By coupling flexible organic field‐effect transistor to a skeletal muscle actuator we demonstrate the feasibility to record in real‐time its contractile behavior when stimulated by electrical ...
Stefano Lai, Judith Fuentes, Maria Guix, Giulia Casula, Piero Cosseddu, Samuel Sánchez   +5 more
wiley   +1 more source

Pharmacologic Mechanisms of Portulaca oleracea L. in the Treatment of Musculoskeletal Disorders: A Mechanistic Review

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
We conducted a comprehensive search of publicly available databases. The main focus is to investigate the pharmacological effects and mechanisms of Portulaca oleracea L. in the treatment of musculoskeletal disorders. This study aims to provide a reference for further research into the active components of this plant. ABSTRACT Portulaca oleracea L. is a
Yanxin Li, Yan Wang, Xiaotian Feng, Qiyu Wang, Hongwei Cui, Tiancheng Ma, Yujing Chen, Jiajun Liu, Jianxiong Ma   +8 more
wiley   +1 more source

Bile acids activate ryanodine receptors in pancreatic acinar cells via a direct allosteric mechanism [PDF]

, 2015
The earliest critical event of pancreatitis is a long lasting high amplitude rise of intracellular Ca(2+) concentration of the acinar cell, which can be triggered by high concentration of bile acids.
Almássy, János, Csernoch, László, Diszházi, Gyula, Geyer, Nikolett, Jóna, István   +4 more
core   +1 more source

Could R‐Ketamine and Wolfram Syndrome Inform Understanding of Depression and Suicidality? A Sigma‐1 Receptor‐Based Perspective

Human Psychopharmacology: Clinical and Experimental, Volume 40, Issue 5, September 2025.
ABSTRACT Loss of function mutations in the WFS1 gene cause Wolfram syndrome, which is characterized by juvenile‐onset diabetes mellitus, diabetes insipidus, neurodegeneration, hearing loss and optic nerve atrophy. Psychiatric symptoms, including major depression and suicidal behavior, are common in this disorder.
Hans O. Kalkman, Lukasz Smigielski
wiley   +1 more source