Results 61 to 70 of about 9,385 (245)

Diazonium Salts in Visible Light Photocatalysis – a Focused Overview of their Application in Continuous Flow Synthesis

ChemPhotoChem, EarlyView.
The combination of continuous flow technology and visible light photocatalysis has been used to improve the safety and productivity of reactions with diazonium salts as reactive intermediates. This approach has proven to be a reliable method for various organic synthesis routes with diazonium salts under mild and well‐defined conditions.
Christoph Deckers, Thomas H. Rehm
wiley   +1 more source

Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure modelKey Findings

Heart Rhythm O2, 2020
Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and ...
Colleen Nofi, DO, Kuo Zhang, MD, PhD, Yi-Da Tang, MD, PhD, Ying Li, BS, Allan Migirov, MBS, Kaie Ojamaa, PhD, A. Martin Gerdes, PhD, Youhua Zhang, MD, PhD   +7 more
doaj  

Clinical Features of Suspected Malignant Hyperthermia in China from 2015 to 2020: A Retrospective Study from China Malignant Hyperthermia Emergency Assistance Group

Journal of Multidisciplinary Healthcare, 2022
Lingcan Tan,1,* Yi Teng,1,* Hong Yu,1 Chunyuan Liu,2 Kun Xiao,3 Jin Yin,4 Yunxia Zuo,1 Tao Zhu,1 Xiaoqian Deng1 1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Department of ...
Tan L, Teng Y, Yu H, Liu C, Xiao K, Yin J, Zuo Y, Zhu T, Deng X   +8 more
doaj  

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review

Anesthesiology, 2019
What We Already Know about This Topic Dantrolene effectively treats malignant hyperthermia, but there are discrepant recommendations for dantrolene availability in facilities that stock succinylcholine for airway rescue but do not use volatile ...
M. G. Larach, Thomas T. Klumpner, B. Brandom, Michelle T. Vaughn, K. Belani, A. Herlich, Tae W. Kim, Janine Limoncelli, S. Riazi, Erica Sivak, J. Capacchione, D. Mashman, S. Kheterpal, F. Kooij, J. Wilczak, R. Soto, Joshua R. Berris, Zachary Price, Steven Lins, P. Coles, John M Harris, K. Cummings, M. Berman, M. Nanamori, B. Adelman, Christopher Wedeven, J. LaGorio, P. McCormick, Simon Tom, M. Aziz, Traci Coffman, Terri A. Ellis, S. Molina, W. Peterson, S. Mackey, W. V. van Klei, A. Ginde, D. Biggs, M. Neuman, R. Craft, N. Pace, William C. Paganelli, M. Durieux, B. Nair, J. Wanderer, Scott A. Miller, D. Helsten, Z. Turnbull, Robert B Schonberger   +48 more
semanticscholar   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

Molecular Neurodegeneration, 2011
Background Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons (MSNs).
Chen Xi, Wu Jun, Lvovskaya Svetlana, Herndon Emily, Supnet Charlene, Bezprozvanny Ilya   +5 more
doaj   +1 more source

A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease

Molecules, 2019
The orphan drug dantrolene (DAN) is the only therapeutic treatment for malignant hyperthermia (MH), a pharmacogenetic pathology affecting 0.2 over 10,000 people in the EU.
Isabella Bolognino, N. Giangregorio, L. Pisani, M. de Candia, Rosa Purgatorio, A. Tonazzi, C. Altomare, S. Cellamare, M. Catto   +8 more
semanticscholar   +1 more source

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

Optimization of dose and route of administration of the P‐glycoprotein inhibitor, valspodar (PSC‐833) and the P‐glycoprotein and breast cancer resistance protein dual‐inhibitor, elacridar (GF120918) as dual infusion in rats

Pharmacology Research & Perspectives, 2021
Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess the
Christopher Rowbottom, Alicia Pietrasiewicz, Taras Tuczewycz, Richard Grater, Daniel Qiu, Sudarshan Kapadnis, Patrick Trapa   +6 more
doaj   +1 more source

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source