Results 61 to 70 of about 6,189 (214)

Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

Molecular Neurodegeneration, 2011
Background Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons (MSNs).
Chen Xi, Wu Jun, Lvovskaya Svetlana, Herndon Emily, Supnet Charlene, Bezprozvanny Ilya   +5 more
doaj   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Difficulties in management of malignant hyperthermia in a rural set up of a developing country

Medical Journal of Dr. D.Y. Patil University, 2014
Lack of availability of dantrolene sodium causes difficulty in management of malignant hyperthermia in different parts of India. We hereby report the case of a seven-year-old girl child who developed malignant hyperthermia and expired in spite of all ...
Debashis Saha, Arunima Chaudhuri, Sumanta Ghosh Maulik, Shankar Ray   +3 more
doaj   +1 more source

Recrudescência fatal de hipertermia maligna em lactente com síndrome de Moebius. Relato de caso

Revista Brasileira de Anestesiologia, 2013
JUSTIFICATIVA E OBJETIVOS: A hipertermia maligna (HM) é uma desordem farmacogenética da musculatura esquelética, caracterizada por estado hipermetabólico após anestesia com succinilcolina e/ou agentes anestésicos voláteis.
Cláudia Regina Fernandes, Washington Aspiculeta Pinto Filho, Lia Cavalcante Cezar, Josenília Maria Alves Gomes, Glauco Kleming Florencio da Cunha   +4 more
doaj   +1 more source

Acute postoperative sepsis mimicking symptomology suspicious for malignant hyperthermia: case report

Brazilian Journal of Anesthesiology, 2019
Background: Sepsis is a life-threatening organ dysfunction with non-specific clinical features that can mimic other clinical conditions with hyper metabolic state such as malignant hyperthermia.
Vendhan Ramanujam, Christopher R. Hoffman, Kevin Russo, Michael S. Green   +3 more
doaj   +1 more source

The potential for one drug, administered at the earliest preclinical stage, to prevent the subsequent decline of cognition that eventuates in dementia

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
In the process that eventuates in mild cognitive impairment (MCI) and ultimately in Alzheimer's dementia, the earliest identifiable change is in the function of synapses.
Jeffrey Fessel
doaj   +1 more source

Fatal Recrudescence of Malignant Hyperthermia in an Infant with Moebius Syndrome

Brazilian Journal of Anesthesiology, 2013
Background and objectives: Malignant hyperthermia (MH) is a pharmacogenetic skeletal muscle disorder characterized by a hypermetabolic state after anesthesia with succinylcholine and/or volatile anesthetics. Various neuromuscular syndromes are associated
Cláudia Regina Fernandes, Washington Aspiculeta Pinto Filho, Lia Cavalcante Cezar, Josenília Maria Alves Gomes, Glauco Kleming Florencio da Cunha   +4 more
doaj   +1 more source

Alcohol and caffeine synergistically induce spontaneous ventricular tachyarrhythmias: ameliorated with dantrolene treatment [PDF]

, 2023
Youhua Zhang, Christopher Kim, Nawal Wasif, Ying Li, Yuan Huang, Satoru Kobayashi, Lars Udo-Bellner, Randy F. Stout, Kaie Ojamaa   +8 more
openalex   +1 more source

Post-Anesthesia Cognitive Dysfunction in Mice Is Associated with an Age-Related Increase in Neuronal Intracellular [Ca²⁺]—Neuroprotective Effect of Reducing Intracellular [Ca²⁺]: In Vivo and In Vitro Studies

Cells
Background: Postoperative cognitive dysfunction (POCD) is a common disorder after general anesthesia in elderly patients, the precise mechanisms of which remain unclear.
Arkady Uryash, Alfredo Mijares, Carlos E. Lopez, Jose A. Adams, Paul D. Allen, Jose R. Lopez   +5 more
doaj   +1 more source

Dantrolene Sodium Can Increase or Attenuate Activity of Skeletal Muscle Ryanodine Receptor Calcium Release Channel [PDF]

, 1996
Thomas E. Nelson, Marina Lin, Gisele Zapata‐Sudo, Roberto T. Sudo   +3 more
openalex   +1 more source