Results 71 to 80 of about 14,850 (297)

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter [PDF]

, 2010
<b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial ...
De Koning, H.P., Quashie, N.B., Ranford-Cartwright, L.C.   +2 more
core   +4 more sources

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review

Anesthesiology, 2019
What We Already Know about This Topic Dantrolene effectively treats malignant hyperthermia, but there are discrepant recommendations for dantrolene availability in facilities that stock succinylcholine for airway rescue but do not use volatile ...
M. G. Larach, Thomas T. Klumpner, B. Brandom, Michelle T. Vaughn, K. Belani, A. Herlich, Tae W. Kim, Janine Limoncelli, S. Riazi, Erica Sivak, J. Capacchione, D. Mashman, S. Kheterpal, F. Kooij, J. Wilczak, R. Soto, Joshua R. Berris, Zachary Price, Steven Lins, P. Coles, John M Harris, K. Cummings, M. Berman, M. Nanamori, B. Adelman, Christopher Wedeven, J. LaGorio, P. McCormick, Simon Tom, M. Aziz, Traci Coffman, Terri A. Ellis, S. Molina, W. Peterson, S. Mackey, W. V. van Klei, A. Ginde, D. Biggs, M. Neuman, R. Craft, N. Pace, William C. Paganelli, M. Durieux, B. Nair, J. Wanderer, Scott A. Miller, D. Helsten, Z. Turnbull, Robert B Schonberger   +48 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Malignant hyperthermia (literature review)

Вестник анестезиологии и реаниматологии, 2023
The objective – to summarize the current literature data on the etiology, pathogenesis, diagnosis and treatment of malignant hyperthermia.   The search and analysis of literature data on malignant hyperthermia in the medical information systems PubMed ...
R. R. Tukhvatullina, N. V. Matinyan
doaj   +1 more source

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Clinical Features of Suspected Malignant Hyperthermia in China from 2015 to 2020: A Retrospective Study from China Malignant Hyperthermia Emergency Assistance Group

Journal of Multidisciplinary Healthcare, 2022
Lingcan Tan,1,* Yi Teng,1,* Hong Yu,1 Chunyuan Liu,2 Kun Xiao,3 Jin Yin,4 Yunxia Zuo,1 Tao Zhu,1 Xiaoqian Deng1 1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Department of ...
Tan L, Teng Y, Yu H, Liu C, Xiao K, Yin J, Zuo Y, Zhu T, Deng X   +8 more
doaj  

Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C

Open Medicine, 2023
Malignant hyperthermia (MH) is an inherited skeletal muscle disorder caused primarily by a genetic mutation, usually in the calcium channel gene of the muscle. This mutation can lead to muscle hypersensitivity to volatile anesthetics (such as sevoflurane)
Lan Haiyan, Duan Gongchen, Zuo Yunxia, Lou Tianzheng, Xu Junlong, Shao Chuxiao, Wu Jimin   +6 more
doaj   +1 more source

Dantrolene inhibits lysophosphatidylcholine-induced valve interstitial cell calcific nodule formation via blockade of the ryanodine receptor

Frontiers in Cardiovascular Medicine, 2023
Calcific aortic valve disease (CAVD), a fibrocalcific thickening of the aortic valve leaflets causing obstruction of the left ventricular outflow tract, affects nearly 10 million people worldwide. For those who reach end-stage CAVD, the only treatment is
Christopher B. Sylvester, Christopher B. Sylvester, Farshad Amirkhosravi, Farshad Amirkhosravi, Angelina S. Bortoletto, Angelina S. Bortoletto, William J. West, William J. West, Jennifer P. Connell, K. Jane Grande-Allen   +9 more
doaj   +1 more source

Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice

Journal of Alzheimer's Disease, 2020
Background/Objective: This study compares the effectiveness and safety of intranasal versus subcutaneous administration of dantrolene in 5XFAD Alzheimer’s disease (AD) mice. Methods: 5XFAD and wild type (WT) B6SJLF1/J mice were treated with intranasal or
Yun Shi, Lei Zhang, Xue Gao, Jing Zhang, Matan Ben Abou, G. Liang, Qingcheng Meng, Adrian Hepner, M. Eckenhoff, Huafeng Wei   +9 more
semanticscholar   +1 more source