Results 71 to 80 of about 9,385 (245)
Difficulties in management of malignant hyperthermia in a rural set up of a developing country
Medical Journal of Dr. D.Y. Patil University, 2014 Lack of availability of dantrolene sodium causes difficulty in management of malignant hyperthermia in different parts of India. We hereby report the case of a seven-year-old girl child who developed malignant hyperthermia and expired in spite of all ...
Debashis Saha +3 more
doaj +1 more source
Dantrolene, A Treatment for Alzheimer Disease? [PDF]
Alzheimer Disease & Associated Disorders, 2015 Alzheimer disease (AD) is a fatal progressive disease and the most common form of dementia without effective treatments. Previous studies support that the disruption of endoplasmic reticulum Ca through overactivation of ryanodine receptors plays an important role in the pathogenesis of AD.
Huafeng Wei, Li Liang
openaire +3 more sources
Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor
Molecular Pharmacology, 2019 Dantrolene is a ryanodine receptor (RyR) inhibitor, which is used to relax muscles in malignant hyperthermia syndrome. Although dantrolene binds to the RyR protein, its mechanism of action is unknown, mainly because of the controversial results showing ...
Gyula Diszházi +6 more
semanticscholar +1 more source
Acta Medica Iranica, 2016 Ryanodine receptor abnormalities has implicated in the generation and maintenance of seizure. Dantrolene, a selective ryanodine receptor antagonist, may be a potential drug for the prevention of seizure.
Mojtaba Keshavarz +2 more
doaj
Endocrinology, Diabetes &Metabolism, Volume 8, Issue 3, May 2025.This correlation study shows that elevated resting calcium levels in skeletal muscle are associated with an increased risk of developing diabetes in an age‐dependent manner. ABSTRACT Background and Aims Skeletal muscle is the primary site for insulin‐mediated glucose uptake and is critical in maintaining whole‐body glucose homeostasis.
Eshwar R. Tammineni +4 more
wiley +1 more source
Malignant hyperthermia (literature review)
Вестник анестезиологии и реаниматологии, 2023 The objective – to summarize the current literature data on the etiology, pathogenesis, diagnosis and treatment of malignant hyperthermia. The search and analysis of literature data on malignant hyperthermia in the medical information systems PubMed ...
R. R. Tukhvatullina, N. V. Matinyan
doaj +1 more source
Dantrolene for the treatment of MDMA toxicity [PDF]
CJEM, 2010 ABSTRACTMDMA (3,4-methylenedioxymethamphetamine), popularly known as “Ecstasy,” was first introduced and patented by Merck & Co., Inc., in 1914 as an appetite suppressant. Currently, its primary role is as an illegal stimulant used to produce a euphoric effect during parties.
Brian Grunau +2 more
openaire +3 more sources
The Journal of Physiology, Volume 603, Issue 10, Page 2959-2978, 15 May 2025.Abstract figure legend Proposed mechanism of regulation of mitochondria on VDCCs mediated Ca2+ signals in smooth muscle cells. Depolarization of the plasma membrane induces Ca2+ influx via L‐type VDCCs that produces a steady elevation in Ca2+ and activates IP3Rs to evoke repetitive Ca2+ release events from the intracellular Ca2+ store.
Xun Zhang +5 more
wiley +1 more source
Successful early application of extracorporeal membrane oxygenation to support cardiopulmonary resuscitation for a patient suffering from severe malignant hyperthermia and cardiac arrest: a case report [PDF]
Korean Journal of Anesthesiology, 2017 Malignant hyperthermia (MH) may lead to metabolic crisis of skeletal muscle in susceptible individuals following exposure to triggering agents such as volatile anesthetics or depolarizing muscle relaxants.
Hyub Huh +5 more
doaj +1 more source
Clinical Practice and Cases in Emergency Medicine, 2019 Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication resulting from neuroleptic drug therapy. Presentation of NMS can vary, and diagnosis relies primarily upon medical history and symptomatology. Due to the potential delay in
V. Ngo +6 more
semanticscholar +1 more source