Results 71 to 80 of about 9,798 (259)

Osmotic pressure‐induced calcium response states

FEBS Open Bio, Volume 15, Issue 10, Page 1714-1722, October 2025.
Acute hypotonic stress triggers distinct calcium response patterns in HEK293T cells. These signals originate from the endoplasmic reticulum via RyR2 and propagate to neighboring cells through gap junctions. This result highlights a novel calcium‐dependent mechanism underlying the intracellular and intercellular response to osmotic pressure.
Zidan Gao, Keiji Naruse, Masatoshi Morimatsu   +2 more
wiley   +1 more source

Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

Molecular Neurodegeneration, 2011
Background Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons (MSNs).
Chen Xi, Wu Jun, Lvovskaya Svetlana, Herndon Emily, Supnet Charlene, Bezprozvanny Ilya   +5 more
doaj   +1 more source

Dantrolene, A Treatment for Alzheimer Disease? [PDF]

Alzheimer Disease & Associated Disorders, 2015
Alzheimer disease (AD) is a fatal progressive disease and the most common form of dementia without effective treatments. Previous studies support that the disruption of endoplasmic reticulum Ca through overactivation of ryanodine receptors plays an important role in the pathogenesis of AD.
Huafeng Wei, Li Liang
openaire   +3 more sources

Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor

Molecular Pharmacology, 2019
Dantrolene is a ryanodine receptor (RyR) inhibitor, which is used to relax muscles in malignant hyperthermia syndrome. Although dantrolene binds to the RyR protein, its mechanism of action is unknown, mainly because of the controversial results showing ...
Gyula Diszházi, Zsuzsanna Magyar, J. Mótyán, L. Csernoch, I. Jóna, P. Nanasi, J. Almássy   +6 more
semanticscholar   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Dantrolene: A Selective Ryanodine Receptor Antagonist, Protects Against Pentylenetetrazole-Induced Seizure in Mice

Acta Medica Iranica, 2016
Ryanodine receptor abnormalities has implicated in the generation and maintenance of seizure. Dantrolene, a selective ryanodine receptor antagonist, may be a potential drug for the prevention of seizure.
Mojtaba Keshavarz, Morteza Fotouhi, Alireza Rasti   +2 more
doaj  

Difficulties in management of malignant hyperthermia in a rural set up of a developing country

Medical Journal of Dr. D.Y. Patil University, 2014
Lack of availability of dantrolene sodium causes difficulty in management of malignant hyperthermia in different parts of India. We hereby report the case of a seven-year-old girl child who developed malignant hyperthermia and expired in spite of all ...
Debashis Saha, Arunima Chaudhuri, Sumanta Ghosh Maulik, Shankar Ray   +3 more
doaj   +1 more source

Pharmacologic Mechanisms of Portulaca oleracea L. in the Treatment of Musculoskeletal Disorders: A Mechanistic Review

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
We conducted a comprehensive search of publicly available databases. The main focus is to investigate the pharmacological effects and mechanisms of Portulaca oleracea L. in the treatment of musculoskeletal disorders. This study aims to provide a reference for further research into the active components of this plant. ABSTRACT Portulaca oleracea L. is a
Yanxin Li, Yan Wang, Xiaotian Feng, Qiyu Wang, Hongwei Cui, Tiancheng Ma, Yujing Chen, Jiajun Liu, Jianxiong Ma   +8 more
wiley   +1 more source

Could R‐Ketamine and Wolfram Syndrome Inform Understanding of Depression and Suicidality? A Sigma‐1 Receptor‐Based Perspective

Human Psychopharmacology: Clinical and Experimental, Volume 40, Issue 5, September 2025.
ABSTRACT Loss of function mutations in the WFS1 gene cause Wolfram syndrome, which is characterized by juvenile‐onset diabetes mellitus, diabetes insipidus, neurodegeneration, hearing loss and optic nerve atrophy. Psychiatric symptoms, including major depression and suicidal behavior, are common in this disorder.
Hans O. Kalkman, Lukasz Smigielski
wiley   +1 more source

Successful early application of extracorporeal membrane oxygenation to support cardiopulmonary resuscitation for a patient suffering from severe malignant hyperthermia and cardiac arrest: a case report [PDF]

Korean Journal of Anesthesiology, 2017
Malignant hyperthermia (MH) may lead to metabolic crisis of skeletal muscle in susceptible individuals following exposure to triggering agents such as volatile anesthetics or depolarizing muscle relaxants.
Hyub Huh, Jae Seung Jung, Sang Jae Park, Min Kyung Park, Choon Hak Lim, Seung Zhoo Yoon   +5 more
doaj   +1 more source