Results 201 to 210 of about 1,049,929 (258)
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Dantrolene sodium: Effects of smooth muscle
European Journal of Pharmacology, 1978The effects of dantrolene sodium on smooth muscle were evaluated in vitro using the guinea pig ileum and the guinea pig vas deferens preparations. Dantrolene irreversibly decreased the strength of the responses of the ileum to acetylcholine, histamine, potassium chloride and electrical stimulation.
Stuart Graves +2 more
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Management of lethal catatonia with dantrolene sodium
Critical Care Medicine, 1991Lethal catatonia, a life-threatening, febrile neuropsychiatric disorder, was reported before the introduction of modern psychopharmacologic treatment. Kraepelin (1) discussed this disorder as a syndrome that comprises a characteristic cluster of symptoms, such as catalepsy, negativism, posturing ...
Jan Gheuens +4 more
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Dantrolene sodium and hepatic injury
Neurology, 1990This is a report on hepatic adverse events associated with dantrolene therapy. All cases reported to the manufacturer are included, from all sources, through 1987. Of 122 cases containing sufficient data to analyze, 47 patients had asymptomatic transaminase elevations, 12 had additional mild (less than or equal to 2.5 mg/dl) hyperbilirubinemia, 36 had ...
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Ineffectiveness of dantrolene sodium in the treatment of heatstroke
Critical Care Medicine, 1991To determine the efficacy of dantrolene sodium in the treatment of heatstroke.Randomized, double-blind, placebo-controlled trial.Heatstroke center in Makkah, Saudi Arabia.Fifty-two adult patients with heatstroke.Patients were assigned to receive either dantrolene sodium (2 mg/kg body weight iv) or placebo.
Khalid El-Assil +5 more
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Hepatitis Associated with Dantrolene Sodium
Annals of Internal Medicine, 1976Excerpt Dantrolene sodium, a hydantoin derivative that became commercially available in 1974, has been used to decrease skeletal muscle spasticity in patients with various disorders (1-3).
Robert M. Ogburn +2 more
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Dantrolene sodium and fatigue of long duration
Muscle & Nerve, 1992AbstractA long‐lasting imparment of muscular force generation follows fatiguing exercise (fatigue of long duration), the physiological basis of which is not well understood. To investigate the role of reduced calcium release in longlasting fatigue, we examined the effects of dantrolene sodium, which selectively decreases calcium release from the ...
Steven L. Lehman +2 more
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Pharmaceutical development and technology (Print)
Topical muscle relaxants are gaining interest in pharmaceuticals. Dantrolene sodium (DS), an FDA-approved relaxant targeting ryanodine receptors, is limited in topical use by poor physicochemical properties, delayed onset, and hepatotoxicity.
Abdelrahaman Mm Othman +2 more
semanticscholar +1 more source
Topical muscle relaxants are gaining interest in pharmaceuticals. Dantrolene sodium (DS), an FDA-approved relaxant targeting ryanodine receptors, is limited in topical use by poor physicochemical properties, delayed onset, and hepatotoxicity.
Abdelrahaman Mm Othman +2 more
semanticscholar +1 more source
Use of dantrolene sodium in external sphincter spasm
Urology, 1976In various neurologic and non-neurologic diseases inappropriate hypertonicity of the external sphincter during micturition may cause outlet obstruction. Heretofore therapy for these disorders has been surgical: pudenal neurectomy or external sphincterotomy. These procedures are not without complication (incontinence, impotence, hemorrhage).
Daniel S. Sax +2 more
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Prevention of recurrent exertional rhabdomyolysis by dantrolene sodium
Muscle & Nerve, 1987AbstractA patient with recurrent attacks of exertional rhabdomyolysis and easy fatiguability was treated with dantrolene sodium. She experienced a complete prevention of myoglobinuric attacks and gained a better exercise tolerance. Biochemical findings in this patient suggest a loosely coupled oxidative phosphorylation in mitochondria.
Haverkort-Poels Pj +2 more
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Neuroleptic Malignant Syndrome: Response to Dantrolene Sodium
Annals of Internal Medicine, 1983Abstract The neuroleptic malignant syndrome is an uncommon and potentially lethal complication of treatment with antipsychotic medication (1).
D C May +4 more
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