Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain [PDF]
Biomedicines, 2023 Diamine oxidase (DAO) is an enzyme that metabolizes intestinal histamine. Single nucleotide polymorphisms (SNPs) of the Amine Oxidase Copper Containing 1 (AOC1) gene can lead to low enzymatic activity or functionality in histamine metabolism.
Gülşah Okutan +8 more
doaj +7 more sources
Histamine intolerance caused by Diamine Oxidase (DAO) deficiency – case report
Journal of Pre-Clinical and Clinical Research, 2022 Histamine is a biogenic amine, which occurs naturally in the human body. Histamine can be metabolised with Diamine Oxidase (DAO) Enzyme. It is estimated that in 1% of people, as a result of an imbalance between the supply and degradation of histamine, a ...
Aleksandra Iwona Zimna +5 more
doaj +6 more sources
Prevalence of Diamine Oxidase Enzyme (DAO) Deficiency in Subjects with Insomnia-Related Symptoms [PDF]
Journal of Clinical MedicineBackground/Objectives: To assess the prevalence of diamine oxidase (DAO) enzyme deficiency caused by single nucleotide polymorphisms (SNPs) of the AOC1 gene in a sample of patients with symptoms of insomnia. Methods: A total of 167 adult patients (> 18 years of age) with symptoms of insomnia attended in a specialized institute for healthy ...
Raquel Lopez Garcia
exaly +4 more sources
Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial [PDF]
Clinical Nutrition, 2019 Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by a deficiency in the enzyme diamine oxidase (DAO). Among histamine related symptoms, headache is one of the most recorded. Current clinical strategies for the treatment of the symptomatology related to this disorder
Oriol Comas-Basté +2 more
exaly +4 more sources
Is histamine intolerance a treatable subtype of fibromyalgia? evidence and clinical implications—narrative review [PDF]
Frontiers in Pain ResearchBackgroundFibromyalgia affects 2%–8% of the global population with suboptimal treatment outcomes. Emerging evidence suggests histamine intolerance, mediated by diamine oxidase (DAO) deficiency, may contribute to fibromyalgia pathophysiology in specific ...
João Protásio Netto +6 more
doaj +2 more sources
The Prevalence of Diamine Oxidase Polymorphisms and Their Association with Histamine Intolerance Symptomatology in the Mexican Population [PDF]
BiomedicinesExogenous histamine obtained from the intake of histamine-rich food is mainly metabolized by the diamine oxidase enzyme (DAO). Histamine intolerance (HIT) is an alteration mainly caused by DAO deficiency, which is commonly associated with ...
Pamela Aguilar-Rodea +8 more
doaj +2 more sources
A case series of diamine oxidase deficiency misdiagnosed as anxiety or panic attacks in patients with tachycardia [PDF]
Indian Journal of PsychiatryBackground: Diamine oxidase (DAO) deficiency, a key marker of histamine intolerance (HIT), often mimics anxiety or panic disorders, leading to a misdiagnoses and delayed treatment.
Ilkay Keskinel
doaj +2 more sources
Mast cell mediators in hereditary angioedema [PDF]
Orphanet Journal of Rare DiseasesBackground Bradykinin-mediated hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH) is often hard to differentiate from mast cell (MC) mediated diseases.
Hanga Réka Horváth +4 more
doaj +2 more sources
Journal of Education, Health and SportIntroduction and purpose Migraine is a prevalent neurological disorder affecting up to 1 billion individuals worldwide. Histamine intolerance, caused by reduced activity of the diamine oxidase enzyme, has been increasingly linked to migraines, with ...
Agata Białek +6 more
doaj +2 more sources
Applied Food ResearchHistamine intolerance is associated with impaired histamine metabolism due to diamine-oxidase (DAO) enzyme deficiency at intestinal level. The recommended strategy to alleviate the symptomatology is a low-histamine diet supplemented with DAO.
Judit Costa-Catala +7 more
doaj +3 more sources