Vaginal Formulations for Prevention of Sexual Transmission of HIV [PDF]
, 2018 According to UNAIDS, as there is still no effective vaccine against HIV, pre-exposure prophylasis (PrEP) is necessary to reduce its incidence. Sexual transmission rate is higher from men to women in developing countries and vertical transmission may also
Cazorla-Luna, Raúl +4 more
core +2 more sources
The science at HIVR4P 2024: The era of choice in biomedical HIV prevention
Journal of the International AIDS Society, Volume 28, Issue 7, July 2025.ABSTRACT Introduction HIVR4P 2024, the 5th HIV Research for Prevention Conference, took place in Lima, Peru, 6–10 October 2024. The conference focused on new developments in HIV prevention from basic research to new product development and implementation science.
Beatriz Grinsztejn +26 more
wiley +1 more source
In Vitro Methods for Evaluating Drug Release of Vaginal Ring Formulations—A Critical Review [PDF]
, 2019 The vagina is a promising site for both local and systemic drug delivery and represents an interesting administration route for compounds with poor oral bioavailability.
Klein, Sandra, Tietz, Katharina
core +1 more source
, 2020 Breastfeeding (BF) women are an important population for biomedicalHIV prevention strategies, but they are rarely included in trials. The 25-mg dapivirinevaginal ring (VR) reduced women’s risk of sexually transmitted HIV infection in twophase 3 trials conducted in Africa.
openaire +2 more sources
Journal of the International AIDS Society, Volume 28, Issue S1, June 2025.Abstract Introduction Post‐exposure prophylaxis (PEP) remains underutilized despite being the only prevention option currently available that covers risk after an exposure. We sought to evaluate uptake and patterns of use of PEP among men and women in rural Uganda and Kenya.
James Ayieko +10 more
wiley +1 more source
Pregnancy and Infant Outcomes Among Women Using the Dapivirine Vaginal Ring in Early Pregnancy
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2018 Background: Monthly use of the dapivirine vaginal ring has been shown to be safe and effective for HIV-1 prevention in nonpregnant reproductive-aged women. The impact of dapivirine on pregnancy outcomes and infant is not known.
Bonus, Makanani +17 more
openaire +3 more sources
Griffithsin Retains Anti-HIV-1 Potency with Changes in gp120 Glycosylation and Complements Broadly Neutralizing Antibodies PGT121 and PGT126. [PDF]
, 2019 Griffithsin (Grft) is an antiviral lectin that has been shown to potently inhibit HIV-1 by binding high-mannose N-linked glycosylation sites on HIV-1 gp120.
Fischer, Kathryn +2 more
core
Update on microbicide research and development-seeking new HIV prevention tools for women [PDF]
, 2011 Women and girls are especially vulnerable to HIV infection in sub-Saharan Africa, and in some of those countries, prevalence among young women can be up to 3 times higher than among men of the same age.
Kaptur, PE, Mertenskoetter, T
core +3 more sources
Brief Report: Dapivirine Ring HIV-1 Prevention Effectiveness for Women Engaged in Vaginal and Anal Intercourse: Insights From Mathematical Modeling. [PDF]
J Acquir Immune Defic Syndr, 2023 Peebles K +12 more
europepmc +1 more source
HIV prevention trial design in an era of effective pre-exposure prophylaxis [PDF]
, 2017 Pre-exposure prophylaxis (PrEP) has demonstrated remarkable effectiveness protecting at-risk individuals from HIV-1 infection. Despite this record of effectiveness, concerns persist about the diminished protective effect observed in women compared with ...
Cuffe, RL +9 more
core +1 more source