Results 81 to 90 of about 2,007,940 (182)

How a menu of adherence support strategies facilitated high adherence to HIV prevention products among adolescent girls and young women in sub‐Saharan Africa: a mixed methods analysis

Journal of the International AIDS Society, 2023
Introduction Effective use of pre‐exposure prophylaxis (PrEP) has been low among adolescent girls and young women (AGYW) in sub‐Saharan Africa. The MTN‐034/REACH trial offered AGYW a menu of adherence support strategies and achieved high adherence to ...
Sarah T. Roberts, Noah Mancuso, Kristin Williams, Hadijah Kalule Nabunya, Hlengiwe Mposula, Caroline Mugocha, Priscilla Mvinjelwa, Morgan Garcia, Daniel W. Szydlo, Lydia Soto‐Torres, Kenneth Ngure, Sybil Hosek   +11 more
doaj   +1 more source

Impact of Tenofovir Alafenamide Sub‐Dermal Implant Insertion Site Scarring on Acceptability and HIV Prevention Preferences: A Prospective Cohort Study in Durban, South Africa

Journal of the International AIDS Society, Volume 29, Issue 4, April 2026.
ABSTRACT Introduction The CAPRISA 018 Phase I trial evaluated the safety, tolerability and pharmacokinetics of a 110 mg tenofovir alafenamide (TAF) implant for HIV prevention in South African women. This follow‐up cohort study, CAPRISA 097, assessed the long‐term resolution of implant site reactions (ISRs) after implant removal and explored user ...
Tanuja N. Gengiah, Lara Lewis, Ishana Harkoo, Nqobile Myeni, Leila E. Mansoor, Salim S. Abdool Karim, Quarraisha Abdool Karim   +6 more
wiley   +1 more source

Residual Amount of Dapivirine (mg) versus Plasma Concentration of Dapivirine (pg/ml).

, 2016
The two lines reflect the linear and exponential relationships evaluated with corresponding regression coefficients (R2). Dapivirine residual levels were assessed for rings dispensed at Weeks 0, 4 and 8 (i.e. returned at Weeks 4, 8 and 12).
Elizabeth Bukusi (342666), Gileard Masenga (478785), Linda-Gail Bekker (60754), Philip Kotze (325818), Elizabeth Montgomery (269905), Cynthia Woodsong (2559826), Elizabeth Hellstrӧm (2559829), Nelisiwe Ndaba (2559832), Neliëtte van Niekerk (325820), Ariane van der Straten (230049), Francis Martinson (410211), Annalene Nel (2559835), Cheryl Louw (346379)   +12 more
core   +1 more source

Investigating the Contribution of Drug-Metabolizing Enzymes in Drug-Drug Interactions of Dapivirine and Miconazole

Pharmaceutics, 2021
Dapivirine (DPV) is a potent NNRTI used to prevent the sexual transmission of HIV. In a phase 1 trial (IPM 028), the concomitant use of a DPV vaginal ring and an antifungal miconazole (MIC) vaginal capsule was found to increase the systemic exposure to ...
Guru Raghavendra Valicherla, Phillip Graebing, Junmei Zhang, Ruohui Zheng, Jeremy Nuttall, Peter Silvera, Lisa Cencia Rohan   +6 more
doaj   +1 more source

Uptake and use of a vaginal ring containing dapivirine for HIV-1 prevention in African women: an open-label extension study

The Lancet HIV, 2021
Background: Two Phase III clinical trials showed that use of a monthly vaginal ring containing 25 mg dapivirine was well-tolerated and reduced HIV-1 incidence in women by approximately 30% compared to placebo (3.3 and 4.1 versus 4.5 and 6.1 per 100 ...
J. Baeten, T. Palanee-Phillips, N. Mgodi, Ashley J. Mayo, D. Szydlo, G. Ramjee, B. G. Mirembe, F. Mhlanga, Portia Hunidzarira, L. Mansoor, Samantha S. Siva, V. Govender, B. Makanani, L. Naidoo, Nishanta Singh, G. Nair, L. Chinula, Urvi M. Parikh, J. Mellors, I. Balán, K. Ngure, A. van der Straten, Rachel Scheckter, Morgan Garcia, Melissa Peda, K. Patterson, E. Livant, K. Bunge, Devika Singh, Cindy E. Jacobson, Yuqing Jiao, C. Hendrix, Z. Chirenje, C. Nakabiito, T. Taha, Judith G. Jones, Kristine Torjesen, A. Nel, Z. Rosenberg, L. Soto-Torres, S. Hillier, E. Brown   +41 more
semanticscholar   +1 more source

Mechanism‐Based Predictions of Local Tissue and Systemic Exposure for Drug Products Delivered Through the Female Reproductive Tract

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Effective drug delivery through the female reproductive tract (FRT) presents unique challenges due to the lack of robust predictive models for drug exposure via this route. Addressing this gap, we developed and evaluated a comprehensive whole‐body physiologically based pharmacokinetic (PBPK) model that incorporates anatomical and physiological
Xinnong Li, Thomas Straubinger, Lisa C. Rohan, Sharon L. Achilles, Beatrice A. Chen, Guru Valicherla, Zhongfang Zhang, Mark Donnelly, Eleftheria Tsakalozou, Liang Zhao, Robert Bies   +10 more
wiley   +1 more source

Safety, adherence, and HIV-1 seroconversion among women using the dapivirine vaginal ring (DREAM): an open-label, extension study.

The Lancet HIV, 2021
BACKGROUND The Ring Study, a phase 3 trial in 1959 sexually active women (randomised 2:1), showed a favourable safety profile and a 31% HIV-1 infection risk reduction for a vaginal ring containing 25 mg of dapivirine, compared with a placebo ring.
A. Nel, Neliëtte van Niekerk, B. van Baelen, M. Malherbe, Winél Mans, Allison Carter, J. Steytler, E. van der Ryst, C. Craig, C. Louw, T. Gwetu, Z. Mabude, P. Kotze, Robert Moraba, H. Tempelman, K. Gill, Sylvia Kusemererwa, L. Bekker, B. Devlin, Z. Rosenberg   +19 more
semanticscholar   +1 more source

Evolving landscape of economic evaluations of HIV pre‐exposure prophylaxis and pre‐exposure prophylaxis implementation strategies: a systematic review

Journal of the International AIDS Society, Volume 28, Issue 11, November 2025.
Abstract Introduction Economic evaluations of HIV pre‐exposure prophylaxis (PrEP) and associated implementation strategies guide evidence‐based policies, programmes and resource allocation. Since 2015, there has been an evolution in PrEP modalities, implementation strategies and prioritization of key populations with unmet HIV prevention needs ...
Min Xi, Darrell H. S. Tan, Stefan D. Baral, Howsikan Kugathasan, Lisa Masucci, Becky Skidmore, Derek R. MacFadden, Kednapa Thavorn, Sharmistha Mishra   +8 more
wiley   +1 more source

Vaginal rings for delivery of HIV microbicides

International Journal of Women's Health, 2012
R Karl Malcolm, Susan M Fetherston, Clare F McCoy, Peter Boyd, Ian MajorSchool of Pharmacy, Queen's University Belfast, Belfast, UKAbstract: Following the successful development of long-acting steroid-releasing vaginal ring devices for the ...
McCoy CF, Fetherston SM, Malcolm RK, Boyd P, Major I   +4 more
doaj  

Oral pre‐exposure prophylaxis initiation, continuation and adherence among pregnant and postpartum women receiving antenatal and postnatal care: a systematic review

Journal of the International AIDS Society, Volume 28, Issue S5, September 2025.
Abstract Introduction In 2023, one‐fourth of new HIV acquisitions in children globally resulted from vertical transmission following incident HIV during pregnancy or breastfeeding. Oral pre‐exposure prophylaxis (PrEP) with tenofovir disoproxil and emtricitabine is safe and effective in pregnancy and postpartum, with long‐acting options emerging ...
Anke Rotsaert, Zaynab Essack, Shannon Bosman, Dvora Joseph Davey, Bernadette Hensen   +4 more
wiley   +1 more source