Results 61 to 70 of about 1,978 (184)

Pre-exposure prophylaxis (PrEP) in an era of stalled HIV prevention: Can it change the game? [PDF]

, 2018
Pre-exposure prophylaxis (PrEP) for HIV prevention has evolved significantly over the years where clinical trials have now demonstrated the efficacy of oral PrEP, and the field is scaling-up implementation.
Eakle, Robyn, Rees, Helen, Venter, Francois   +2 more
core   +1 more source

Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir [PDF]

Journal of Antimicrobial Chemotherapy, 2014
Combination microbicide vaginal rings may be more effective than single microbicide rings at reducing/preventing sexual transmission of HIV. Here, we report the pre-clinical development and macaque pharmacokinetics of matrix-type silicone elastomer vaginal rings containing dapivirine and darunavir.Macaque rings containing 25 mg dapivirine, 100 mg ...
Murphy, Diarmaid J., Desjardins, Delphine, Dereuddre-Bosquet, Nathalie, Brochard, Patricia, Perrot, Ludivine, Pruvost, Alain, Le Grand, Roger, Lagatie, Ole, Vanhooren, Leen, Feyaerts, Maxim, van Roey, Jens, Malcolm, R. Karl   +11 more
openaire   +4 more sources

Preferences for ARV-based HIV prevention methods among men and women, adolescent girls and female sex workers in Gauteng Province, South Africa: a protocol for a discrete choice experiment. [PDF]

, 2016
INTRODUCTION: For the past few decades, condoms have been the main method of HIV prevention. Recent advances in antiretroviral (ARV)-based prevention products have substantially changed the prevention landscape, yet little is known about how popular ...
Cabrera, Maria, Cianci, Fiona, Delany-Moretlwe, Sinead, Eakle, Robyn, Quaife, Matthew, Terris-Prestholt, Fern, Tsepe, Motlalepule, Vickerman, Peter   +7 more
core   +3 more sources

Reasons for nonadherence to the dapivirine vaginal ring

AIDS, 2018
MTN-020/ASPIRE trial and IPM-027/Ring Study recently proved the dapivirine vaginal ring was safe and effective with consistent use. To optimize the ring's impact, the barriers and facilitators to ring adherence must be understood and addressed.Former ASPIRE participants were stratified by age group (18-21; 22-45) and randomly selected at seven sites in
Elizabeth T, Montgomery, Jonathan, Stadler, Sarita, Naidoo, Ariana W K, Katz, Nicole, Laborde, Morgan, Garcia, Krishnaveni, Reddy, Leila E, Mansoor, Juliane, Etima, Chifundo, Zimba, Miria, Chitukuta, Lydia, Soto-Torres   +11 more
openaire   +3 more sources

Efficient regulatory approval of two novel HIV prevention interventions in a resource-limited setting: experiences from Zimbabwe

Frontiers in Reproductive Health, 2023
The global burden of HIV remains unacceptably high despite significant progress made in HIV treatment and prevention. There is an urgent need to scale up the comprehensive HIV prevention strategies that include pre-exposure prophylaxis (PrEP).
Caroline Murombedzi, Libert Chirinda, Gift T. Chareka, Z. Mike Chirenje, Nyaradzo M. Mgodi   +4 more
doaj   +1 more source

Evaluation of polycaprolactone matrices for the intravaginal delivery of metronidazole in the treatment of bacterial vaginosis [PDF]

, 2014
Microporous, poly (ε-caprolactone) (PCL) matrices loaded with the antibacterial, metronidazole were produced by rapidly cooling suspensions of drug powder in PCL solutions in acetone. Drug incorporation in the matrices increased from 2.0% to 10.6% w/w on
Coombes, Allan G. A., Palmer, Cheryn, Pathak, Meenakshi, Turner, Mark   +3 more
core   +1 more source

Baseline preferences for oral pre-exposure prophylaxis (PrEP) or dapivirine intravaginal ring for HIV prevention among adolescent girls and young women in South Africa, Uganda and Zimbabwe (MTN-034/IPM-045 study).

PLoS ONE, 2023
IntroductionAdolescent girls and young women (AGYW) in sub-Saharan Africa are disproportionately affected by the HIV epidemic and face an array of challenges using proven behavioral and biomedical prevention methods.
Kenneth Ngure, Barbara A Friedland, Daniel W Szydlo, Sarah T Roberts, Morgan Garcia, Lisa Levy, Carolyne A Akello, Krishnaveni Reddy, Thesla Palanee-Phillips, Pippa Macdonald, Bekezela Siziba, Lydia Soto-Torres, Sybil Hosek, Sharon L Hillier, Gonasagrie Nair, Connie Celum, Ariane van der Straten   +16 more
doaj   +1 more source

Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors [PDF]

, 2018
Indolylarylsulfones are a potent class of human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors. In this review, the structure activity relationship (SAR) studies to improve the profile of sulfone L-737,126 discovered by ...
Famiglini, V., Silvestri, R.
core   +1 more source

Vaginal contraception: a roadmap to women's reproductive autonomy-a narrative review [PDF]

, 2023
The right to contraception information and services is one of the essential rights of every woman that guarantees access to safe, acceptable, available, and good-quality contraceptives.
Kumar, Naina
core   +2 more sources

The impact of an educational intervention on undergraduate students’ knowledge, acceptability, and willingness to pay for dapivirine vaginal ring in Nigeria's first indigenous university: a single-arm, non-randomized study

Discover Social Science and Health
Background This study aimed to assess the impact of an educational intervention on knowledge, acceptability, and willingness to pay (WTP) for dapivirine vaginal ring (DPV-VR) by undergraduate female students at the University of Nigeria (UNN).
Abdulmuminu Isah, Gabriel Ezenri, Ogechi Obi, Nnamdi A. Okibe, Hadiza Usman Ma’aji, Ezinwanne J. Ugochukwu, Cynthia C. Eze, Chisom M. Amoke, Augustus Ezeodimegwu, Charles C. Idabor, Mustapha Muhammed Abubakar, Francis Iloabuchi, Ikenna John Ugwu, Chukwuebuka M. Asogwa, Chinwe V. Ukwe, Blessing Onyinye Ukoha-kalu   +15 more
doaj   +1 more source