Results 61 to 70 of about 2,007,940 (182)

Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel [PDF]

International Journal of Pharmaceutics, 2016
A matrix-type silicone elastomer vaginal ring providing 28-day continuous release of dapivirine (DPV) - a lead candidate human immunodeficiency virus type 1 (HIV-1) microbicide compound - has recently demonstrated moderate levels of protection in two Phase III clinical studies.
Peter Boyd, Susan M. Fetherston, Clare F. McCoy, Ian Major, Diarmaid J. Murphy, Sandeep Kumar, Jonathon Holt, Andrew Brimer, Wendy Blanda, Brid Devlin, R. Karl Malcolm   +10 more
openaire   +4 more sources

Evaluating the potential impact and cost-effectiveness of dapivirine vaginal ring pre-exposure prophylaxis for HIV prevention.

PLoS ONE, 2019
BackgroundExpanded HIV prevention options are needed to increase uptake of HIV prevention among women, especially in generalized epidemics. As the dapivirine vaginal ring moves forward through regulatory review and open-label extension studies, the ...
Meghan Reidy, Elizabeth Gardiner, Carel Pretorius, Robert Glaubius, Kristine Torjesen, Katharine Kripke   +5 more
doaj   +1 more source

Planning for decentralized, simplified prEP: Learnings from potential end users in Ga-Rankuwa, gauteng, South Africa

Frontiers in Reproductive Health, 2023
BackgroundIn South Africa, youth experience challenges with oral Pre-Exposure Prophylaxis (PrEP) access and uptake. Taking services out of healthcare settings has the potential to increase reach and overcome these challenges.
Paballo Mataboge, Susan Nzenze, Nqaba Mthimkhulu, Mbali Mazibuko, Alison Kutywayo, Vusile Butler, Nicolette Naidoo, Saiqa Mullick   +7 more
doaj   +1 more source

Reasons for nonadherence to the dapivirine vaginal ring

AIDS, 2018
MTN-020/ASPIRE trial and IPM-027/Ring Study recently proved the dapivirine vaginal ring was safe and effective with consistent use. To optimize the ring's impact, the barriers and facilitators to ring adherence must be understood and addressed.Former ASPIRE participants were stratified by age group (18-21; 22-45) and randomly selected at seven sites in
Elizabeth T, Montgomery, Jonathan, Stadler, Sarita, Naidoo, Ariana W K, Katz, Nicole, Laborde, Morgan, Garcia, Krishnaveni, Reddy, Leila E, Mansoor, Juliane, Etima, Chifundo, Zimba, Miria, Chitukuta, Lydia, Soto-Torres   +11 more
openaire   +3 more sources

Clinical testing of antiretroviral drugs as future prevention against vaginal and rectal transmission of HIV infection – a review of currently available results

Acta Pharmaceutica, 2019
The original purpose of vaginally applied microbicides was to slow down the HIV epidemic among the population until an effective vaccination was developed.
Vysloužil Jakub, Kubová Kateřina, Tkadlečková Veronika Nováková, Vetchý David   +3 more
doaj   +1 more source

“It’s already in your body and it’s preventing”: a qualitative study of African female adolescent’s acceptability and preferences for proxy HIV prevention methods in Cape Town, South Africa

BMC Public Health, 2023
Background Advances in biomedical HIV prevention will soon offer young women a choice of HIV prevention methods, including various pre-exposure prophylaxis (PrEP) modalities such as daily oral pills, dapivirine vaginal ring, and long-acting injectable ...
Lauren Fynn, Katherine Gill, Melissa Wallace, Millicent Atujuna, Menna Duyver, Penelope Ngcobo, Hans Spiegel, Alex Rinehart, Sybil Hosek, Linda-Gail Bekker   +9 more
doaj   +1 more source

Adolescent Girls and Young Women’s Experiences with Disclosing Oral PrEP or Dapivirine Vaginal Ring Use: a Multi-Country Qualitative Analysis

Aids and Behavior, 2023
Effective use of oral pre-exposure prophylaxis (PrEP) has been low among adolescent girls and young women (AGYW) in Eastern and Southern Africa, partly due to stigma and opposition from key influencers.
Alinda M. Young, Noah Mancuso, M. Atujuna, Siyanda Tenza, Miria Chitukuta, Doreen Kemigisha, K. Ngure, A. van der Straten, Morgan Garcia, D. Szydlo, L. Soto-Torres, Sarah T. Roberts   +11 more
semanticscholar   +1 more source

The impact of participant engagement activities in supporting dapivirine ring use among participants enrolled in the Phase III MTN-020/ASPIRE study

, 2021
Background: Low adherence to investigational products can negatively impact study outcomes, limiting the ability to demonstrate efficacy. To continue advancing potential new HIV prevention technologies for at-risk individuals, efforts are needed to ...
Morgan Garcia, E. Luecke, Ashley J. Mayo, Rachel Scheckter, P. Ndase, F. M. Kiweewa, Doreen Kemigisha, L. Mansoor, Nishanta Singh, K. Woeber, N. Morar, Nitesha Jeenarain, Z. Gaffoor, Daniel K. Gondwe, Yvonne Makala, K. Reddy, T. Palanee-Philips, J. Baeten, A. van der Straten, L. Soto-Torres, Kristine Torjesen, P. Musara   +21 more
semanticscholar   +1 more source

Two into one does go: Formulation development of a multipurpose combination vaginal ring releasing dapivirine and metronidazole for prevention of HIV infection and treatment of bacterial vaginosis.

International journal of pharmaceutics, 2023
Bacterial vaginosis (BV) is a common but often asymptomatic dysbiosis of the human vagina characterized by an imbalance in the normal vaginal microbiota due to loss of lactobacilli and an overgrowth of certain anaerobic bacteria. While BV itself is not a
Xin-Yu Zhao, Peter Boyd, Yahya H. Dallal Bashi, Diarmaid J. Murphy, C. McCoy, S. Coulter, Garry Laverty, R. K. Malcolm   +7 more
semanticscholar   +1 more source

Impact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaques [PDF]

International Journal of Pharmaceutics, 2018
This work investigates the impact of vaginal ring size and drug loading on the in vitro release, safety, ease of fit, and pharmacokinetics in cynomolgus macaques of matrix-type silicone elastomer vaginal rings containing a combination of the non-nucleoside reverse transcriptase inhibitor dapivirine and the protease inhibitor darunavir.
Murphy, Diarmaid J., Desjardins, Delphine, Boyd, Peter, Dereuddre-Bosquet, Nathalie, Stimmer, Lev, Caldwell, Anna, Le Grande, Roger, Kelly, Charles, Van Roey, Jens, Malcolm, R. Karl   +9 more
openaire   +4 more sources