Results 51 to 60 of about 2,007,940 (182)

Multipurpose vaginal rings for HIV prevention and non-hormonal contraception

British Journal of Pharmacy, 2022
Vaginal rings releasing antiretrovirals - either alone or in combination with contraceptive progestins - are being developed for contraception and prevention of human immunodeficiency virus (HIV) transmission via vagina.
Xin Shen, Peter Boyd, Yahya Dallal Bashi, Clare McCoy , Karl Malcolm   +4 more
doaj   +1 more source

Assessment of risk compensation following use of the dapivirine vaginal ring in southwestern Uganda [PDF]

Sexually Transmitted Infections, 2021
ObjectivesParticipation in HIV prevention trials could trigger risk compensation among participants. We evaluated potential risk compensation following use of a vaginal ring microbicide by women in a phase III trial in southwestern Uganda.MethodsWe used markers of sexual risk behaviour documented on standardised questionnaires, tested for STIs at ...
Sylvia Kusemererwa, Andrew Abaasa, Anita Kabarambi, Martin Onyango, Joseph Okello Mugisha   +4 more
openaire   +2 more sources

Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings

International Journal of Pharmaceutics: X, 2021
Vaginal rings releasing antiretrovirals – either alone or in combination with contraceptive progestins – are being developed for prevention of human immunodeficiency virus (HIV) transmission via vaginal sex.
Clare F. McCoy, Patrick Spence, Yahya H. Dallal Bashi, Diarmaid J. Murphy, Peter Boyd, Bindi Dangi, Tiffany Derrick, Bríd Devlin, Kyle Kleinbeck, R. Karl Malcolm   +9 more
doaj   +1 more source

Brief Report: Phase IIa Safety Study of a Vaginal Ring Containing Dapivirine in Adolescent Young Women [PDF]

, 2020
BackgroundYoung women aged 15-24 years are disproportionately affected by the HIV epidemic. Two phase III trials of a vaginal ring containing 25-mg dapivirine demonstrated HIV-1 risk reduction in adult women older than 21 years but not in those aged 18 ...
Daniel W. Szydlo, Annalene Nel, Mark A. Marzinke, Soto-Torres, Lydia, Lydia Soto-Torres, Marzinke, Mark A, Hendrix, Craig W, MTN-023/IPM 030 Study Team, Kapogiannis, Bill, Aditya H. Gaur, Mayer, Kenneth H, Craig Hoesley, Bunge, Katherine E, Sharon L. Hillier, Nel, Annalene, Pamina M. Gorbach, Levy, Lisa, Zhang, Jingyang, Craig M. Wilson, Szydlo, Daniel W, Craig W. Hendrix, Kenneth H. Mayer, Katherine E. Bunge, Hillier, Sharon L, Squires, Kathleen E, Donna Futterman, Gaur, Aditya H, Reirden, Daniel, Futterman, Donna, Hoesley, Craig, Gorbach, Pamina M, Daniel Reirden, Lisa Levy, Kathleen E. Squires, Bill Kapogiannis, Wilson, Craig M, Jingyang Zhang   +36 more
core   +1 more source

Dapivirine Ring: The Case for Action [PDF]

, 2017
The monthly dapivirine ring, the first discrete, long-acting, HIV prevention product designed specifically for women, will soon be on the market.* Women account for over half of adult HIV infections in sub-Saharan Africa, but have few HIV prevention ...
Neeraja Bhavaraju
core   +2 more sources

Dapivirine Vaginal Ring for HIV Prevention in Women in South Africa

Infectious Diseases, 2022
Young women remain disproportionately affected by the HIV epidemic in South Africa. Clinical trials have shown that the dapivirine vaginal ring (DVR) is safe and effective at reducing HIV infection in women. In March 2022, the South African Health Products Regulatory Authority approved the use of the DVR in women aged 18 years and older who are unable ...
Linda-Gail Bekker, Katherine Gill
openaire   +1 more source

Dapivirine-releasing vaginal rings produced by plastic freeforming additive manufacturing [PDF]

International Journal of Pharmaceutics, 2019
Here we report the first use of an additive manufacturing (AM) technique based on high pressure material jetting of molten thermoplastic for the fabrication of dapivirine (DPV) loaded vaginal rings (VRs). The VRs are compared to those produced conventionally using injection molding (IM).
Nicole R. Welsh, R. Karl Malcolm, Brid Devlin, Peter Boyd   +3 more
openaire   +4 more sources

Transport and Permeation Properties of Dapivirine: Understanding Potential Drug-Drug Interactions

Pharmaceutics, 2022
The dapivirine (DPV) vaginal ring was developed by the nonprofit International Partnership for Microbicides (IPM) for reducing the risk of HIV infection.
Ruohui Zheng, Guru R. Valicherla, Junmei Zhang, Jeremy Nuttall, Peter Silvera, Leslie J. Marshall, Philip E. Empey, Lisa C. Rohan   +7 more
doaj   +1 more source

Experiences with simultaneous use of contraception and the vaginal ring for HIV prevention in sub-Saharan Africa

BMC Women's Health, 2021
Background Clinical trials have found that a monthly dapivirine vaginal ring was well-tolerated and reduced HIV-1 risk among women in sub-Saharan Africa.
Jonah Leslie, Flavia Kiweewa, Thesla Palanee-Phillips, Katherine Bunge, Felix Mhlanga, Betty Kamira, Jared Baeten, Ariana Katz, Sharon Hillier, Elizabeth Montgomery, for the MTN-020/ASPIRE Study Team   +10 more
doaj   +1 more source

Characteristics of Women Enrolled into a Randomized Clinical Trial of Dapivirine Vaginal Ring for HIV-1 Prevention.

PLoS ONE, 2015
IntroductionWomen in sub-Saharan Africa are a priority population for evaluation of new biomedical HIV-1 prevention strategies. Antiretroviral pre-exposure prophylaxis is a promising prevention approach; however, clinical trials among young women using ...
Thesla Palanee-Phillips, Katie Schwartz, Elizabeth R Brown, Vaneshree Govender, Nyaradzo Mgodi, Flavia Matovu Kiweewa, Gonasagrie Nair, Felix Mhlanga, Samantha Siva, Linda-Gail Bekker, Nitesha Jeenarain, Zakir Gaffoor, Francis Martinson, Bonus Makanani, Sarita Naidoo, Arendevi Pather, Jessica Phillip, Marla J Husnik, Ariane van der Straten, Lydia Soto-Torres, Jared Baeten   +20 more
doaj   +1 more source