Results 31 to 40 of about 2,007,940 (182)

Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir [PDF]

Journal of Antimicrobial Chemotherapy, 2014
Combination microbicide vaginal rings may be more effective than single microbicide rings at reducing/preventing sexual transmission of HIV. Here, we report the pre-clinical development and macaque pharmacokinetics of matrix-type silicone elastomer vaginal rings containing dapivirine and darunavir.Macaque rings containing 25 mg dapivirine, 100 mg ...
Murphy, Diarmaid J., Desjardins, Delphine, Dereuddre-Bosquet, Nathalie, Brochard, Patricia, Perrot, Ludivine, Pruvost, Alain, Le Grand, Roger, Lagatie, Ole, Vanhooren, Leen, Feyaerts, Maxim, van Roey, Jens, Malcolm, R. Karl   +11 more
openaire   +5 more sources

Safety and drug quantification of the dapivirine vaginal ring and oral pre-exposure prophylaxis in breastfeeding mother-infant pairs (MTN-043): a phase 3B, open-label, randomised trial. [PDF]

Lancet HIV
Summary Background In 2021, WHO recommended dapivirine vaginal rings (DVRs) for HIV prevention, but noted evidence gaps for breastfeeding populations.
Noguchi LM, Owor M, Mgodi NM, Gati Mirembe B, Dadabhai S, Horne E, Gundacker H, Richardson BA, Bunge K, Scheckter R, Song M, Marzinke MA, Anderson PL, Livant E, Jacobson C, Piper JM, Chakhtoura N, Hillier SL, Balkus JE, MTN-043 Study Team.   +19 more
europepmc   +2 more sources

Estimated adherence to the Dapivirine Vaginal Ring and its associated factors among African women: A systematic review and meta-analysis. [PDF]

PLOS Global Public Health
The Dapivirine Vaginal Ring (DVR), a silicone circular ring, continuously distributes Dapivirine into the vagina to prevent HIV infection. We summarized evidence on adherence to DVR for HIV-1 prevention among African women 16-45 years old and described ...
Roseline Dzekem Dine, Giulia M Muraca, Behnam Sadeghirad, Rachel Couban, Agatha Nyambi, Jéssyca Silva, Lawrence Mbuagbaw   +6 more
doaj   +2 more sources

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women [PDF]

Obstetrical & Gynecological Survey, 2016
Antiretroviral medications that are used as prophylaxis can prevent acquisition of human immunodeficiency virus type 1 (HIV-1) infection. However, in clinical trials among African women, the incidence of HIV-1 infection was not reduced, probably because of low adherence. Longer-acting methods of drug delivery, such as vaginal rings, may simplify use of
Baeten, Jared M, Palanee-Phillips, Thesla, Brown, Elizabeth R, Schwartz, Katie, Soto-Torres, Lydia E, Govender, Vaneshree, Mgodi, Nyaradzo M, Matovu Kiweewa, Flavia, Nair, Gonasagrie, Mhlanga, Felix, Siva, Samantha, Bekker, Linda-Gail, Jeenarain, Nitesha, Gaffoor, Zakir, Martinson, Francis, Makanani, Bonus, Pather, Arendevi, Naidoo, Logashvari, Husnik, Marla, Richardson, Barbra A, Parikh, Urvi M, Mellors, John W, Marzinke, Mark A, Hendrix, Craig W, van der Straten, Ariane, Ramjee, Gita, Chirenje, Zvavahera M, Nakabiito, Clemensia, Taha, Taha E, Jones, Judith, Mayo, Ashley, Scheckter, Rachel, Berthiaume, Jennifer, Livant, Edward, Jacobson, Cindy, Ndase, Patrick, White, Rhonda, Patterson, Karen, Germuga, Donna, Galaska, Beth, Bunge, Katherine, Singh, Devika, Szydlo, Daniel W, Montgomery, Elizabeth T, Mensch, Barbara S, Torjesen, Kristine, Grossman, Cynthia I, Chakhtoura, Nahida, Nel, Annalene, Rosenberg, Zeda, McGowan, Ian, Hillier, Sharon   +51 more
openaire   +7 more sources

Risk Compensation in the Context of Sexually Transmitted Infections in Women Using the Dapivirine Vaginal Ring in Africa: A Scoping Review. [PDF]

Int J Sex Health
Background Sexually transmitted infections (STIs) remain a critical public health challenge globally, with Africa facing the highest incidence and mortality rates. The Dapivirine Vaginal Ring (DVR) is a discreet HIV prevention tool for women but does not
Dine RD, Ogunniyi TJ, Yisa SS, Rutaganira E, Sindayigaya P, Batisani K, Ojo J, Wazhi GB, Oke AE, Damilola IA, Shitindo M, Wirsiy FS.   +11 more
europepmc   +2 more sources

Baseline preferences for oral pre-exposure prophylaxis (PrEP) or dapivirine intravaginal ring for HIV prevention among adolescent girls and young women in South Africa, Uganda and Zimbabwe (MTN-034/IPM-045 study).

PLoS ONE, 2023
IntroductionAdolescent girls and young women (AGYW) in sub-Saharan Africa are disproportionately affected by the HIV epidemic and face an array of challenges using proven behavioral and biomedical prevention methods.
Kenneth Ngure, Barbara A Friedland, Daniel W Szydlo, Sarah T Roberts, Morgan Garcia, Lisa Levy, Carolyne A Akello, Krishnaveni Reddy, Thesla Palanee-Phillips, Pippa Macdonald, Bekezela Siziba, Lydia Soto-Torres, Sybil Hosek, Sharon L Hillier, Gonasagrie Nair, Connie Celum, Ariane van der Straten   +16 more
doaj   +2 more sources

HIV-1 testing in the context of expanding PrEP modalities. [PDF]

J Int AIDS Soc
Abstract Introduction Multiple effective antiretroviral‐based pre‐exposure prophylaxis (PrEP) modalities for HIV‐1 prevention are now available or under investigation but their safe rollout requires implementable HIV‐1 testing strategies that accurately identify rare cases of HIV‐1 acquisition.
Parikh UM, Jacobs JL, Njuguna N, Torjesen K, Mellors JW.   +4 more
europepmc   +2 more sources

Adherence, safety, and choice of the monthly dapivirine vaginal ring or oral emtricitabine plus tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis among African adolescent girls and young women: a randomised, openlabel, crossover trial

The Lancet HIV, 2023
Summary Background Half of new HIV acquisitions in Africa occur in adolescent girls and young women (AGYW). Preexposure prophylaxis (PrEP) with oral emtricitabine/tenofovir disoproxil fumarate and the dapivirine ring are efficacious but have lower ...
G. Nair, C. Celum, D. Szydlo, Elizabeth R. Brown, Carolyne A. Akello, R. Nakalega, Pippa Macdonald, Gakiema Milan, T. Palanee-Phillips, K. Reddy, Eunice Tahuringana, Felix Muhlanga, C. Nakabiito, L. Bekker, B. Siziba, Sharon L. Hillier, J. Baeten, Morgan Garcia, Sherri Johnson, Tara McClure, L. Levy, E. Livant, Cindy E. Jacobson, L. Soto-Torres, A. van der Straten, S. Hosek, James F. Rooney, J. Steytler, K. Bunge, Urvi M. Parikh, Craig W. Hendrix, Peter L. Anderson, K. Ngure   +32 more
semanticscholar   +2 more sources

A Review and Economic Analysis of the Dapivirine Vaginal Ring as HIV Pre-Exposure Prophylaxis for Women, to Inform South African Public-Sector Guidelines. [PDF]

J Acquir Immune Defic Syndr
Supplemental Digital Content is Available in the Text. Background: South Africa has a high HIV incidence and oral pre-exposure prophylaxis (PrEP) is available as public-sector standard of care.
Leong TD, Nel J, Jamieson L, Osih R, Dawood H, Subedar H, McCaul M, Johnson LF, Cohen K.   +8 more
europepmc   +2 more sources

Impact of Dapivirine and Placebo Vaginal Rings on the Microbiota of Adolescent, Lactating, and Postmenopausal Females

Journal of Infectious Diseases, 2021
Abstract Background A 25-mg dapivirine vaginal ring has been demonstrated to reduce risk of human immunodeficiency virus (HIV) acquisition in nonpregnant adult women. In this secondary analysis of studies conducted in US adolescent, lactating, and postmenopausal females, vaginal microbiota was ...
Beatrice Chen, Richard Beigi, Lisa A Cosentino   +2 more
exaly   +3 more sources