Results 11 to 20 of about 1,978 (184)

Packing polymorphism of dapivirine and its impact on the performance of a dapivirine-releasing silicone elastomer vaginal ring [PDF]

Journal of Pharmaceutical Sciences, 2017
PRISMA Checklist (PDF 545Â ...
McCoy, Clare F., Murphy, Diarmaid J., Boyd, Peter, Derrick, Tiffany, Spence, Patrick, Devlin, Brid, Malcolm, Robert   +6 more
core   +10 more sources

User and healthcare provider early experiences with the PrEP ring: a quantitative study on the introduction of a new PrEP method in Eswatini [PDF]

Journal of the International AIDS Society
Introduction Eswatini prepared for the national rollout of HIV pre‐exposure prophylaxis (PrEP) choice through a mixed‐method demonstration study introducing the PrEP dapivirine vaginal ring in 12 Ministry of Health‐supported sites. The Eswatini PrEP Ring
Anita Hettema, Siphesihle Shongwe, Haley Sisel, Mxolisi Khumalo, Ncediso Gama, Nolwazi Khanyile, Buyile Mahlalela, Sindy Nana Matse, Jill M. Peterson   +8 more
doaj   +3 more sources

Acceptability of the Dapivirine Vaginal Ring in Postmenopausal US Women

AIDS Patient Care and STDs, 2022
For women in the United States who remain sexually active beyond child-bearing years, susceptibility to HIV infection remains, yet condom use is low. We assessed acceptability of the dapivirine vaginal ring (ring) among 96 postmenopausal US women enrolled in a placebo-controlled multisite phase II trial of the ring, using questionnaires and in-depth ...
Mary Kate Shapley-Quinn, Nicole Laborde, Ellen Luecke, Craig Hoesley, Robert A. Salata, Sherri Johnson, Annalene Nel, Lydia Soto-Torres, Beatrice A. Chen, Ariane van der Straten   +9 more
openaire   +4 more sources

Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women [PDF]

New England Journal of Medicine, 2016
The incidence of human immunodeficiency virus (HIV) infection remains high among women in sub-Saharan Africa. We evaluated the safety and efficacy of extended use of a vaginal ring containing dapivirine for the prevention of HIV infection in 1959 healthy, sexually active women, 18 to 45 years of age, from seven communities in South Africa and Uganda.In
Annalene, Nel, Neliëtte, van Niekerk, Saidi, Kapiga, Linda-Gail, Bekker, Cynthia, Gama, Katherine, Gill, Anatoli, Kamali, Philip, Kotze, Cheryl, Louw, Zonke, Mabude, Nokuthula, Miti, Sylvia, Kusemererwa, Hugo, Tempelman, Hannelie, Carstens, Brid, Devlin, Michelle, Isaacs, Mariëtte, Malherbe, Winel, Mans, Jeremy, Nuttall, Marisa, Russell, Smangaliso, Ntshele, Marlie, Smit, Leonard, Solai, Patrick, Spence, John, Steytler, Kathleen, Windle, Maarten, Borremans, Sophie, Resseler, Jens, Van Roey, Wim, Parys, Tony, Vangeneugden, Ben, Van Baelen, Zeda, Rosenberg   +32 more
exaly   +5 more sources

Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel

International Journal of Pharmaceutics: X, 2021
A dapivirine-releasing silicone elastomer vaginal ring for reducing women's risk of HIV acquisition has recently been approved. A next-generation multipurpose vaginal ring releasing dapivirine and levonorgestrel is currently in development, offering ...
Yahya H. Dallal Bashi, Diarmaid J. Murphy, Clare F. McCoy, Peter Boyd, Leeanne Brown, Matthew Kihara, François Martin, Nicole McMullen, Kyle Kleinbeck, Bindi Dangi, Patrick Spence, Bashir Hansraj, Brid Devlin, R. Karl Malcolm   +13 more
doaj   +5 more sources

Pharmacokinetics of Dapivirine Transfer into Blood Plasma, Breast Milk, and Cervicovaginal Fluid of Lactating Women Using the Dapivirine Vaginal Ring [PDF]

Antimicrobial Agents and Chemotherapy, 2019
Breastfeeding (BF) women are an important population for biomedical HIV prevention strategies, but they are rarely included in trials. The 25-mg dapivirine vaginal ring (VR) reduced women’s risk of sexually transmitted HIV infection in two phase 3 trials conducted in Africa.
Lisa M. Noguchi, Craig Hoesley, Cliff Kelly, Rachel Scheckter, Katherine Bunge, Annalene Nel, Mark A. Marzinke, Craig W. Hendrix, Charlene S. Dezzutti, Sharon L. Hillier, Debra L. Bogen, Jeanna M. Piper, Richard H. Beigi   +12 more
openaire   +6 more sources

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women [PDF]

Obstetrical & Gynecological Survey, 2016
Antiretroviral medications that are used as prophylaxis can prevent acquisition of human immunodeficiency virus type 1 (HIV-1) infection. However, in clinical trials among African women, the incidence of HIV-1 infection was not reduced, probably because of low adherence. Longer-acting methods of drug delivery, such as vaginal rings, may simplify use of
Baeten, Jared M, Palanee-Phillips, Thesla, Brown, Elizabeth R, Schwartz, Katie, Soto-Torres, Lydia E, Govender, Vaneshree, Mgodi, Nyaradzo M, Matovu Kiweewa, Flavia, Nair, Gonasagrie, Mhlanga, Felix, Siva, Samantha, Bekker, Linda-Gail, Jeenarain, Nitesha, Gaffoor, Zakir, Martinson, Francis, Makanani, Bonus, Pather, Arendevi, Naidoo, Logashvari, Husnik, Marla, Richardson, Barbra A, Parikh, Urvi M, Mellors, John W, Marzinke, Mark A, Hendrix, Craig W, van der Straten, Ariane, Ramjee, Gita, Chirenje, Zvavahera M, Nakabiito, Clemensia, Taha, Taha E, Jones, Judith, Mayo, Ashley, Scheckter, Rachel, Berthiaume, Jennifer, Livant, Edward, Jacobson, Cindy, Ndase, Patrick, White, Rhonda, Patterson, Karen, Germuga, Donna, Galaska, Beth, Bunge, Katherine, Singh, Devika, Szydlo, Daniel W, Montgomery, Elizabeth T, Mensch, Barbara S, Torjesen, Kristine, Grossman, Cynthia I, Chakhtoura, Nahida, Nel, Annalene, Rosenberg, Zeda, McGowan, Ian, Hillier, Sharon   +51 more
openaire   +7 more sources

Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel [PDF]

International Journal of Pharmaceutics, 2016
A matrix-type silicone elastomer vaginal ring providing 28-day continuous release of dapivirine (DPV) - a lead candidate human immunodeficiency virus type 1 (HIV-1) microbicide compound - has recently demonstrated moderate levels of protection in two ...
Blanda, Wendy, Boyd, Peter, Brimer, Andrew, Devlin, Brid, Fetherston, Susan M, Holt, Jonathon, Kumar, Sandeep, Major, Ian, Malcolm, R Karl, McCoy, Clare F, Murphy, Diarmaid J   +10 more
core   +7 more sources

Oral pre-exposure prophylaxis implementation in South Africa: a case study of USAID-supported programs [PDF]

Frontiers in Reproductive Health
Since the introduction of oral pre-exposure prophylaxis (PrEP) in 2016, countries have successfully scaled-up PrEP to populations at risk of HIV acquisition, including key populations, serodiscordant couples and pregnant women.
Jerome Wendoh Milimu, Lauren Parmley, Mahlodi Matjeng, Mathata Madibane, Mandisi Mabika, Jacques Livingston, Joseph Lawrence, Orapeleng Motlhaoleng, Hasina Subedar, Rethabile Tsekoa, Zandile Mthembu   +10 more
doaj   +2 more sources

Values and preferences of female sex workers in Zimbabwe for long-acting injectable pre-exposure prophylaxis and the dapivirine vaginal ring: results of a mixed-methods research study [PDF]

BMJ Global Health
Introduction Female sex workers (FSWs) in sub-Saharan Africa are at high risk of HIV acquisition. Here we explore the values and preferences of Zimbabwean FSW for long-acting pre-exposure prophylaxis (PrEP).Methods We employed mixed methods; focus group ...
Frances M Cowan, Sungai T Chabata, Rachel Baggaley, Michelle Rodolph, Marc d'Elbée, Fortunate Machingura, Tatenda Kujeke, Jasper Maguma   +7 more
doaj   +2 more sources