Results 21 to 30 of about 2,007,940 (182)

User and healthcare provider early experiences with the PrEP ring: a quantitative study on the introduction of a new PrEP method in Eswatini [PDF]

Journal of the International AIDS Society
Introduction Eswatini prepared for the national rollout of HIV pre‐exposure prophylaxis (PrEP) choice through a mixed‐method demonstration study introducing the PrEP dapivirine vaginal ring in 12 Ministry of Health‐supported sites. The Eswatini PrEP Ring
Anita Hettema, Siphesihle Shongwe, Haley Sisel, Mxolisi Khumalo, Ncediso Gama, Nolwazi Khanyile, Buyile Mahlalela, Sindy Nana Matse, Jill M. Peterson   +8 more
doaj   +3 more sources

Leveraging international stakeholders’ experiences with oral PrEP costs to accelerate implementation of the monthly dapivirine vaginal ring: A qualitative study [PDF]

Health Research Policy and Systems
Background Costing and financing systematic implementation are recognized barriers to human immunodeficiency virus (HIV) prevention. In the absence of empiric implementation and economic data, perspectives from international stakeholders involved in ...
Craig J. Heck, Katharine Kripke, Anita Dam, Sergio Torres-Rueda, Fiammetta Bozzani, Chris Obermeyer, Kibret Yohannes, Justine Deacon, Kathrine Meyers, Daniela Quigee, Sarah Wiant, Steven Forsythe, Christine Malati, Martha Larson, Magdalena E. Sobieszczyk, Delivette Castor   +15 more
doaj   +3 more sources

Brief Report: Dapivirine Ring HIV-1 Prevention Effectiveness for Women Engaged in Vaginal and Anal Intercourse: Insights From Mathematical Modeling. [PDF]

J Acquir Immune Defic Syndr, 2023
Background: The dapivirine vaginal ring reduces risk of HIV-1 acquisition in acts of vaginal intercourse (VI), and though it does not offer HIV-1 protection in acts of anal intercourse (AI), it may provide some overall risk reduction for women for whom ...
Peebles K, Brown ER, Hendrix CW, Palanee-Phillips T, van der Straten A, Harkoo I, Reddy K, Mirembe BG, Jeenarain N, Hillier SL, Baeten JM, Barnabas RV, MTN-020/ASPIRE study team.   +12 more
europepmc   +2 more sources

Integration of a Relationship-focused Counseling Intervention with Delivery of the Dapivirine Ring for HIV Prevention to Women in Johannesburg: Results of the CHARISMA Pilot Study. [PDF]

AIDS Behav, 2022
Biomedical, female-initiated HIV prevention methods can help reduce disproportionately high HIV rates among women in sub-Saharan Africa, but male partner resistance and intimate partner violence (IPV) may impact ability to ensure effective use.
Montgomery ET, Roberts ST, Reddy K, Tolley E, Hartmann M, Wilson E, Mathebula F, Wagner LD, Zissette S, Lanham M, Wilcher R, Baeten JM, Palanee-Phillips T.   +12 more
europepmc   +2 more sources

HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial. [PDF]

J Int AIDS Soc, 2021
A potential concern with the use of dapivirine (DPV) for HIV prevention is the selection of a drug‐resistant virus that could spread and reduce the effectiveness of non‐nucleoside reverse transcriptase (NNRTI)‐based first‐line antiretroviral therapy.
Parikh UM, Penrose KJ, Heaps AL, Halvas EK, Goetz BJ, Gordon KC, Hardesty R, Sethi R, Schwarzmann W, Szydlo DW, Husnik MJ, Chandran U, Palanee-Phillips T, Baeten JM, Mellors JW, MTN-020 Study Team.   +15 more
europepmc   +2 more sources

Client-Centered Adherence Counseling with Adherence Measurement Feedback to Support Use of the Dapivirine Ring in MTN-025 (The HOPE Study). [PDF]

AIDS Behav, 2021
Fostering adherence and open communication about adherence challenges is key to harnessing the potential of biomedical HIV prevention products. We describe the counseling intervention and objective adherence measure feedback process implemented to ...
Balán IC, Giguere R, Lentz C, Kutner BA, Kajura-Manyindo C, Byogero R, Asiimwe FB, Makala Y, Jambaya J, Khanyile N, Chetty D, Soto-Torres L, Mayo A, Mgodi NM, Palanee-Phillips T, Baeten JM.   +15 more
europepmc   +2 more sources

Higher Acceptability of the Monthly Dapivirine Ring Versus Daily Oral Pre-Exposure Prophylaxis Among Adolescent Girls and Young Women in Sub-Saharan Africa in the REACH Trial. [PDF]

J Acquir Immune Defic Syndr
Background: Oral pre-exposure prophylaxis (PrEP) is effective for HIV prevention, yet use has been inconsistent in adolescent girls and young women (AGYW). We compared PrEP with the dapivirine vaginal ring (ring) among AGYW in MTN-034 (REACH).
Friedland BA, Browne EN, Roberts ST, Ngure K, Nakalega R, Macdonald P, Mpongo CN, Tenza S, Mhlanga N, Szydlo D, Johnson S, McClure T, Nair G, Celum C, Hillier SL, van der Straten A, MTN-034 REACH clinical trial team.   +16 more
europepmc   +2 more sources

Acceptability of the Dapivirine Vaginal Ring in Postmenopausal US Women

AIDS Patient Care and STDs, 2022
For women in the United States who remain sexually active beyond child-bearing years, susceptibility to HIV infection remains, yet condom use is low. We assessed acceptability of the dapivirine vaginal ring (ring) among 96 postmenopausal US women enrolled in a placebo-controlled multisite phase II trial of the ring, using ...
Robert A. Salata, Ariane van der Straten, Mary Kate Shapley-Quinn   +2 more
exaly   +3 more sources

Use of the dapivirine vaginal ring and effect on cervical cytology abnormalities [PDF]

AIDS, 2020
Objective: We aimed to determine if the dapivirine vaginal ring and the ring device alone (flexible silicone matrix polymer) was associated with the development of cervical cytology abnormalities. Design: Secondary analysis comparing cervical cytology results between two randomized ...
Reddy, Krishnaveni, Kelly, Cliff, Brown, Elizabeth R, Jeenarain, Nitesha, Naidoo, Logashvari, Siva, Samantha, Bekker, Linda-Gail, Nair, Gonasagrie, Makanani, Bonus, Chinula, Lameck, Mgodi, Nyaradzo, Chirenje, Zvavahera, Kiweewa, Flavia Matovu, Marrazzo, Jeanne, Bunge, Katherine, Soto-Torres, Lydia, Piper, Jeanna, Baeten, Jared M, Palanee-Phillips, Thesla   +18 more
openaire   +6 more sources

Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa. [PDF]

PLoS ONE, 2016
BackgroundThis was the first microbicide trial conducted in Africa to evaluate an antiretroviral-containing vaginal ring as an HIV prevention technology for women.ObjectivesThe trial assessed and compared the safety, acceptability and adherence to ...
Annalene Nel, Linda-Gail Bekker, Elizabeth Bukusi, Elizabeth Hellstrӧm, Philip Kotze, Philip Kotze, Cheryl Louw, Francis Martinson, Gileard Masenga, Elizabeth Montgomery, Nelisiwe Ndaba, Ariane van der Straten, Neliëtte van Niekerk, Cynthia Woodsong   +13 more
doaj   +2 more sources