Results 41 to 50 of about 2,007,940 (182)

Safety, acceptability, and adherence to dapivirine vaginal ring and oral pre-exposure prophylaxis for HIV prevention in the second trimester of pregnancy: a multicountry, open-label, phase 3b randomised trial. [PDF]

Lancet HIV
Summary Background: Pregnant women are at 4-times higher risk of HIV per coital act than non-pregnant women. MTN-042/DELIVER was a phase 3b randomised study of the dapivirine vaginal ring (DVR) and oral tenofovir disoproxil fumarate/emtricitabine (TDF ...
Mhlanga FG, Szydlo DW, Mayo AJ, Bunge K, Fairlie L, Nakabiito C, Musara P, Mgodi NM, Dadabhai S, Scheckter R, Anderson PL, Marzinke MA, Chappell C, Gadama LA, Richardson BA, Piper JM, Hillier SL, MTN-042 DELIVER study team.   +17 more
europepmc   +2 more sources

Associations between intravaginal practices and incidence of sexually transmitted infections and bacterial vaginosis among women enrolled in the dapivirine vaginal ring trial (The Ring Study) in southwestern Uganda: a retrospective secondary analysis

BMJ Open
Objectives We assessed associations between intravaginal practices (IVPs) and the incidence of sexually transmitted infections (STIs) and bacterial vaginosis (BV) among women using the dapivirine vaginal ring (DVR) or placebo vaginal ring in southwestern
Andrew Abaasa, Eugene Ruzagira, Sylvia Kusemererwa, Anita Kabarambi, Martin Onyango   +4 more
doaj   +2 more sources

Oral pre-exposure prophylaxis implementation in South Africa: a case study of USAID-supported programs [PDF]

Frontiers in Reproductive Health
Since the introduction of oral pre-exposure prophylaxis (PrEP) in 2016, countries have successfully scaled-up PrEP to populations at risk of HIV acquisition, including key populations, serodiscordant couples and pregnant women.
Jerome Wendoh Milimu, Lauren Parmley, Mahlodi Matjeng, Mathata Madibane, Mandisi Mabika, Jacques Livingston, Joseph Lawrence, Orapeleng Motlhaoleng, Hasina Subedar, Rethabile Tsekoa, Zandile Mthembu   +10 more
doaj   +2 more sources

PrEP preferences and early acceptability of injectable cabotegravir among pregnant and lactating people in Cape Town, South Africa: findings from the PrEPared to Choose study. [PDF]

J Int AIDS Soc
Abstract Introduction Providing pregnant and lactating people (PLP) with choice in HIV pre‐exposure prophylaxis (PrEP) methods, including long‐acting injectable cabotegravir (CAB‐LA), may mitigate barriers to effective PrEP use. We evaluated PrEP preferences and acceptability among PLP offered CAB‐LA versus oral PrEP in South Africa.
Wara N, Pike C, Rousseau E, Macdonald P, Mapukata P, Leonard B, Lebelo K, Hoffman R, Orrell C, Bekker LG, Davey DJ.   +10 more
europepmc   +2 more sources

PrEP and choice counselling – Insights into implementation [PDF]

Journal of Public Health in Africa
Adolescent girls and young women are disproportionately affected by human immunodeficiency virus (HIV). The introduction of oral pre-exposure prophylaxis (PrEP) was a game-changer in HIV prevention.
Melanie Pleaner, Faith Musvipwa, Siphokazi Dada, Fatima A. Cholo, Catherine E. Martin, Alison Kutywayo, Vusile Butler, Saiqa Mullick   +7 more
doaj   +2 more sources

The dapivirine vaginal ring from the perspective of married men in Uganda [PDF]

African Journal of AIDS Research, 2021
Background: Men play a key role in influencing uptake of women's health products, such as female condoms and vaginal microbicides used for family planning and HIV prevention.Method: We explored men's perceptions of the dapivirine vaginal ring (DVR), a vaginal microbicide, in Kalungu District, rural south-western Uganda.
Anita Kabarambi, Sylvia Kusemererwa, Emily Krogstad, Philippe Mayaud, Janet Seeley, Joseph Mugisha, Mitzy Gafos   +6 more
openaire   +3 more sources

In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel

International Journal of Pharmaceutics: X, 2022
We have previously reported a multipurpose silicone elastomer vaginal ring providing sustained release of dapivirine (an antiretroviral) and levonorgestrel (a progestin) for HIV prevention and hormonal contraception.
Diarmaid J. Murphy, Yahya H. Dallal Bashi, Clare F. McCoy, Peter Boyd, Leeanne Brown, François Martin, Nicole McMullen, Kyle Kleinbeck, Bindi Dangi, Patrick Spence, Bashir Hansraj, Bríd Devlin, R. Karl Malcolm   +12 more
doaj   +1 more source

Strategies implemented for accurate dispensing of an investigational new drug in a multi-site HIV prevention clinical trial

Contemporary Clinical Trials Communications, 2021
Safe practices for dispensing investigational product (IP) during clinical trials are not standardized and information in this regard is often limited.
Cindy Jacobson, Jayajothi Moodley, Aruna Bhoola, Rebecca Sakwa, Jeeva Moodley, Jasmin Sukdao, Nivriti Hurbans, Bhavna Maharaj, Anushka Naidoo, Melanie Maclachlan, Gift Chareka, Kudzai Hlahla, Mary Chadza   +12 more
doaj   +1 more source

Promises and potential pitfalls of long-acting injectable pre-exposure prophylaxis

Southern African Journal of HIV Medicine, 2023
The number of products that can provide pre-exposure prophylaxis (PrEP) for HIV prevention is expanding, with three now approved in South Africa (oral Tenofovir-based PrEP, injectable Cabotegravir, and a Dapivirine-based vaginal ring) and more in the ...
Carey Pike, Elzette Rousseau, Linda-Gail Bekker   +2 more
doaj   +1 more source

Acceptability and use of a dapivirine vaginal ring in a phase III trial [PDF]

AIDS, 2017
The MTN-020/ASPIRE trial evaluated the safety and effectiveness of the dapivirine vaginal ring for prevention of HIV-1 infection among African women. A nested qualitative component was conducted at six of 15 study sites in Uganda, Malawi, Zimbabwe and South Africa to evaluate acceptability of and adherence to the ring.Qualitative study participants (n =
Elizabeth T, Montgomery, Ariane, van der Straten, Miria, Chitukuta, Krishnaveni, Reddy, Kubashni, Woeber, Millicent, Atujuna, Linda-Gail, Bekker, Juliane, Etima, Teopista, Nakyanzi, Ashley J, Mayo, Ariana, Katz, Nicole, Laborde, Cynthia I, Grossman, Lydia, Soto-Torres, Thesla, Palanee-Phillips, Jared M, Baeten   +15 more
openaire   +4 more sources