Results 71 to 80 of about 2,007,940 (182)

Efficient regulatory approval of two novel HIV prevention interventions in a resource-limited setting: experiences from Zimbabwe

Frontiers in Reproductive Health, 2023
The global burden of HIV remains unacceptably high despite significant progress made in HIV treatment and prevention. There is an urgent need to scale up the comprehensive HIV prevention strategies that include pre-exposure prophylaxis (PrEP).
Caroline Murombedzi, Libert Chirinda, Gift T. Chareka, Z. Mike Chirenje, Nyaradzo M. Mgodi   +4 more
doaj   +1 more source

A multipurpose silicone elastomer vaginal ring releasing dapivirine and Cu2+/Zn2+ ions for HIV prevention and non-hormonal contraception.

International journal of pharmaceutics
A dapivirine (DPV)-releasing vaginal ring (DapiRing®, containing 25 mg DPV) has been approved in various African countries for prevention of human immunodeficiency virus type 1 (HIV-1).
Xin Shen, Peter Boyd, Yahya H. Dallal Bashi, C. McCoy, Xin-Yu Zhao, R. Malcolm   +5 more
semanticscholar   +1 more source

Acceptability of the Dapivirine Vaginal Ring and Oral Truvada Among African Users in Late-Stage of Pregnancy

Aids and Behavior, 2023
The Microbicide Trials Network 042 study (MTN-042/DELIVER) is a two-arm, randomized, open-label Phase 3b trial that is evaluating the safety, adherence, and acceptability of the monthly ring and daily oral PrEP among HIV-uninfected pregnant people in ...
Elizabeth T. Montgomery, Imogen Hawley, L. Fairlie, Katie Bunge, Florence Mathebula, J. Etima, Prisca Mutero, Linly Senyama, Ashley J. Mayo, Marie C. D. Stoner, Jeanna M. Piper, Iván C. Balán, A. van der Straten   +12 more
semanticscholar   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

HIV Drug Resistance Assessment among Women who Seroconverted during the MTN-025/HOPE Open-Label Extension Dapivirine Vaginal Ring Trial

Journal of Acquired Immune Deficiency Syndromes, 2023
Background: Clinical trials of dapivirine vaginal ring have shown it is safe, effective, and desired by women as an HIV prevention option. The risk of drug resistance is a potential concern for dapivirine ring users who acquire HIV.
Urvi M. Parikh, Kerri J. Penrose, Amy L. Heaps, Rahil Sethi, B. Goetz, Daniel W. Szydlo, U. Chandran, T. Palanee-Phillips, N. Mgodi, J. Baeten, John W. Mellors   +10 more
semanticscholar   +1 more source

Latin America and the Caribbean: Challenges and Opportunities for HIV Treatment and Prevention

Journal of the International AIDS Society, Volume 29, Issue S3, July 2026.
ABSTRACT Introduction In Latin America, there are rising numbers of new HIV acquisitions, while the Caribbean has achieved decreases in both new acquisitions and AIDS‐related deaths. The Latin American and Caribbean (LAC) region has worked towards widely available treatment for people with HIV (PWHIV) within public health systems and, in Latin America,
Mateo Prochazka, Kelika A. Konda, Omar Sued, Hortencia Peralta, Andrea Boccardi, Thiago S. Torres, Monica Alonso, Valdilea Veloso, Beatriz Grinsztejn   +8 more
wiley   +1 more source

Prevotella bivia Influences Antiretroviral Pharmacokinetics and Viral Replication in an Ex Vivo Vaginal Tissue Model

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT The vaginal microbiome plays a complex role in tenofovir's mucosal pharmacology. While the relative contribution of systemic versus local concentrations to PrEP PK/PD is an ongoing debate, the development of effective HIV prevention requires an understanding of events at the site of transmission.
Alyssa M. Lantz, Lindsey B. Collins, Elizabeth B. Hirsch, Christopher Staley, Melanie R. Nicol   +4 more
wiley   +1 more source

“Male-supported, female-initiated”

Communicare, 2022
HIV and AIDS remain one of the leading public health challenges in the world, with young women in sub-Saharan Africa bearing the brunt of HIV infection.
Eliza Govender, Yonela Vukapi, Phiwe Nota   +2 more
doaj   +1 more source

Exploring the potential of dapivirine vaginal ring for HIV prevention in Namibia: a call to action 

The Medical Journal of Zambia, 2023
The recent recommendation by the World Health organization for the use of the dapivirine vaginal ring as a promising safe, efficacious and alternate choice for HIV prevention among women at significant risk of infection presents a welcome development for
M. A. Chipare
semanticscholar   +1 more source

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source