Results 71 to 80 of about 1,978 (184)
The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.Abstract Effective drug delivery through the female reproductive tract (FRT) presents unique challenges due to the lack of robust predictive models for drug exposure via this route. Addressing this gap, we developed and evaluated a comprehensive whole‐body physiologically based pharmacokinetic (PBPK) model that incorporates anatomical and physiological
Xinnong Li +10 more
wiley +1 more source
Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women [PDF]
Clinical Infectious Diseases, 2018 Postmenopausal women have unique sociobiological human immunodeficiency virus (HIV) risks. We evaluated the safety, pharmacokinetics, and acceptability of a microbicide dapivirine (DPV) vaginal ring (VR) versus placebo in postmenopausal women.We enrolled 96 HIV-negative postmenopausal US women in a phase 2a double-blind, randomized (3:1) trial of ...
Beatrice A Chen +18 more
openaire +2 more sources
“Male-supported, female-initiated”
Communicare, 2022 HIV and AIDS remain one of the leading public health challenges in the world, with young women in sub-Saharan Africa bearing the brunt of HIV infection.
Eliza Govender +2 more
doaj +1 more source
Bacterial biofilms in the vagina [PDF]
, 2017 A bacterial biofilm is a structured community of bacteria in a self-produced extracellular matrix, adherent to an inert surface or biological tissue. The involvement of biofilm in a bacterial infection implies that the infection is difficult to treat and
Cerca, Nuno +4 more
core +1 more source
Journal of the International AIDS Society, Volume 28, Issue 11, November 2025.Abstract Introduction Economic evaluations of HIV pre‐exposure prophylaxis (PrEP) and associated implementation strategies guide evidence‐based policies, programmes and resource allocation. Since 2015, there has been an evolution in PrEP modalities, implementation strategies and prioritization of key populations with unmet HIV prevention needs ...
Min Xi +8 more
wiley +1 more source
Journal of the International AIDS Society, 2023 Introduction Effective use of pre‐exposure prophylaxis (PrEP) has been low among adolescent girls and young women (AGYW) in sub‐Saharan Africa. The MTN‐034/REACH trial offered AGYW a menu of adherence support strategies and achieved high adherence to ...
Sarah T. Roberts +11 more
doaj +1 more source
Rationale and safety assessment of a novel intravaginal drug-delivery system with sustained DL-lactic acid release, intended for long-term protection of the vaginal microbiome [PDF]
, 2016 Bacterial vaginosis is a prevalent state of dysbiosis of the vaginal microbiota with wide-ranging impact on human reproductive health. Based on recent insights in community ecology of the vaginal microbiome, we hypothesize that sustained vaginal DL ...
Remon, Jean Paul +2 more
core +4 more sources
Journal of the International AIDS Society, Volume 28, Issue S5, September 2025.Abstract Introduction In 2023, one‐fourth of new HIV acquisitions in children globally resulted from vertical transmission following incident HIV during pregnancy or breastfeeding. Oral pre‐exposure prophylaxis (PrEP) with tenofovir disoproxil and emtricitabine is safe and effective in pregnancy and postpartum, with long‐acting options emerging ...
Anke Rotsaert +4 more
wiley +1 more source
Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal Contraception [PDF]
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2017 Objective: To evaluate the potential for a clinically relevant drug–drug interaction with concomitant use of a dapivirine vaginal ring, a novel antiretroviral-based HIV-1 prevention strategy, and hormonal contraception by examining contraceptive efficacies with and without dapivirine ring use ...
Jennifer E, Balkus +16 more
openaire +2 more sources
Pharmaceutics, 2021 Dapivirine (DPV) is a potent NNRTI used to prevent the sexual transmission of HIV. In a phase 1 trial (IPM 028), the concomitant use of a DPV vaginal ring and an antifungal miconazole (MIC) vaginal capsule was found to increase the systemic exposure to ...
Guru Raghavendra Valicherla +6 more
doaj +1 more source